The March webinar Cannabinoid Hyperemesis Syndrome: Does cannabis land you in hot water? Harm, Hope, or Hype? Lessons in the era of legalization, featured Dr. Thangam Venkatesan, who presented an in-depth overview of cannabinoid hyperemesis syndrome (CHS), a condition characterized by recurrent vomiting associated with chronic cannabis use. The session explored how CHS clinically resembles Cyclic Vomiting Syndrome, while emphasizing the challenges of diagnosis using Rome Foundation criteria, which require sustained cannabis abstinence to confirm causation. Dr. Venkatesan reviewed current treatment strategies—including the use of sumatriptan and neuromodulators such as amitriptyline—and discussed how factors like cannabis potency and route of administration may influence symptom development. The webinar concluded with a dynamic discussion on management approaches, underlying mechanisms, and the critical need for further research to better understand and treat CHS.