Publications

2026

Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode
Shim S, Jeong H, Bommersbach T, Nierenberg A, Zarate C, Kaster T, Correll C, McIntyre R, Krystal J, Rhee T. Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode. JAMA Psychiatry 2026, 83 PMID: 42090166, PMCID: PMC13150733, DOI: 10.1001/jamapsychiatry.2026.0612.
Peer-Reviewed Original Research
Concepts
A Meta-Analysis of Drift-Diffusion Modeling of Self-Referential Processing and Relations with Depressive Symptoms
Edgar E, Ibrahim K, Bloch M, Crowley M. A Meta-Analysis of Drift-Diffusion Modeling of Self-Referential Processing and Relations with Depressive Symptoms. Computational Brain & Behavior 2026, 1-18. DOI: 10.1007/s42113-026-00283-x.
Peer-Reviewed Original Research
Concepts
Lower synaptic density in mood circuitry underlies depression in Parkinson’s disease
Cayir S, Naganawa M, Volpi T, Sadabad F, Dias M, Yang Y, Elliott S, Ansari M, Elshahat A, Pittman B, Esterlis I, Nabulsi N, Huang Y, Sanacora G, Comley R, Finnema S, Carson R, Tinaz S, Matuskey D, Holmes S. Lower synaptic density in mood circuitry underlies depression in Parkinson’s disease. Brain Communications 2026, 8: fcag136. PMID: 42109687, PMCID: PMC13152014, DOI: 10.1093/braincomms/fcag136.
Peer-Reviewed Original Research
Concepts
Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J
Khattar N, Matuskey D, Gallezot J, Naganawa M, Holmes S, Sadabad F, Mayeli M, Esterlis I, van Dyck C, Mecca A, D’Souza D, Nabulsi N, Finnema S, Huang Y, Carson R, Toyonaga T. Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261441071. PMID: 41960765, PMCID: PMC13068773, DOI: 10.1177/0271678x261441071.
Peer-Reviewed Original Research
Concepts
Trajectories of late-life depression: insights from molecular imaging
Holmes S, Smith G. Trajectories of late-life depression: insights from molecular imaging. Neuropsychopharmacology 2026, 1-19. PMID: 41922490, DOI: 10.1038/s41386-026-02340-2.
Peer-Reviewed Original Research
Medically Recommended Cannabis Use for U.S. Adolescents
Bommersbach T, Olfson M, Rhee T. Medically Recommended Cannabis Use for U.S. Adolescents. American Journal Of Preventive Medicine 2026, 71: 108355. PMID: 41903661, DOI: 10.1016/j.amepre.2026.108355.
Peer-Reviewed Original Research
Concepts
Influence of self-referential processing on depression and anxiety: A meta-analysis of cognitive biases and task variants
Edgar E, Reid L, Marco L, Sawada Y, Ibrahim K, Bloch M, Crowley M. Influence of self-referential processing on depression and anxiety: A meta-analysis of cognitive biases and task variants. Journal Of Psychiatric Research 2026, 198: 240-251. PMID: 41931984, PMCID: PMC13176957, DOI: 10.1016/j.jpsychires.2026.03.035.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Developing Physician-Scientists Through Integrated Child and Adolescent Psychiatry Clinical and Research Training Programs
Veenstra-VanderWeele J, Brown L, Martin A, Muhle R, Jacob S, Drury S, Bloch M, Grice D, Rogers C, Stevens H, Stroeh O, Szatmari P. Developing Physician-Scientists Through Integrated Child and Adolescent Psychiatry Clinical and Research Training Programs. Journal Of The American Academy Of Child And Adolescent Psychiatry 2026 PMID: 41881301, DOI: 10.1016/j.jaac.2026.03.013.
Peer-Reviewed Original Research
Concepts
Phase 2 Clinical Trial of MK-1942, a Negative Allosteric Modulator of Metabotropic Glutamate Receptor 2, for Treatment-Resistant Depression.
Merola A, Mukai Y, Bueters T, Ceesay P, Dupre N, Furtek C, Sanacora G, Thase M, Targum S, Smith S, Egan M. Phase 2 Clinical Trial of MK-1942, a Negative Allosteric Modulator of Metabotropic Glutamate Receptor 2, for Treatment-Resistant Depression. Journal Of Clinical Psychopharmacology 2026 PMID: 41854661, DOI: 10.1097/jcp.0000000000002171.
Peer-Reviewed Original Research
Concepts
Comment on Esketamine 5 Years After Approval: Welcome New Data With Continuing Questions.
Ahmed M, Cabrera P, Doherty T, Himedan M, Kern D, Turkoz I, Sanacora G. Comment on Esketamine 5 Years After Approval: Welcome New Data With Continuing Questions. American Journal Of Psychiatry 2026, appiajp20251203. PMID: 41844563, DOI: 10.1176/appi.ajp.20251203.
Peer-Reviewed Original Research
Editorial: Should Weight Gain be a Factor in Choosing an Antidepressant?
Behling E, Bloch M. Editorial: Should Weight Gain be a Factor in Choosing an Antidepressant? Journal Of The American Academy Of Child And Adolescent Psychiatry 2026 PMID: 41856244, DOI: 10.1016/j.jaac.2026.03.008.
Peer-Reviewed Original Research
Concepts
Effect of Ketamine on Reward Processing in Depressive Disorders: A Systematic Review of Neuroimaging Studies.
Faisal H, Le G, Kwan A, Wong S, Cheung W, Dri C, Cao B, Rhee T, Bargiota S, Lo H, Shen B, Guillen-Burgos H, McIntyre R. Effect of Ketamine on Reward Processing in Depressive Disorders: A Systematic Review of Neuroimaging Studies. CNS Spectrums 2026, 1-36. PMID: 41804256, DOI: 10.1017/s109285292610087x.
Peer-Reviewed Original Research
Concepts
The association between obsessive-compulsive symptoms and self-compassion: A meta-analysis and systematic review
Shnayder S, Funaro M, Ching T, Pittenger C, Kelmendi B, Adams T, Agin-Liebes G. The association between obsessive-compulsive symptoms and self-compassion: A meta-analysis and systematic review. Journal Of Affective Disorders 2026, 405: 121546. PMID: 41796771, DOI: 10.1016/j.jad.2026.121546.
Peer-Reviewed Original Research
Concepts
Neural correlates linked to developmental and affective disorder–related self-referential processing: an ALE meta-analysis
Sawada Y, Edgar E, Ibrahim K, Reid L, Gadassi-Polack R, Bloch M, Crowley M. Neural correlates linked to developmental and affective disorder–related self-referential processing: an ALE meta-analysis. Cerebral Cortex 2026, 36: bhag031. PMID: 41860307, PMCID: PMC13017888, DOI: 10.1093/cercor/bhag031.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol
Wilkinson S, Prashad S, Dalthorp R, Harding L, Kitay B, Parikh S, Dziura J, Clayton A, Fram G, Lepoutre V, Brown J, Ostroff R, Sanacora G. Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol. Contemporary Clinical Trials 2026, 164: 108273. PMID: 41780747, DOI: 10.1016/j.cct.2026.108273.
Peer-Reviewed Original Research
Concepts
Insufficient Sleep Among US Adolescents Across Behavioral Risk Groups
Bommersbach T, Olfson M, Rhee T. Insufficient Sleep Among US Adolescents Across Behavioral Risk Groups. JAMA: The Journal Of The American Medical Association 2026, 335 PMID: 41770537, PMCID: PMC12954592, DOI: 10.1001/jama.2026.1417.
Peer-Reviewed Original Research
Concepts
Association of Recent and Past Homelessness with Health-Related Quality of Life among US Adults
Lo E, Rhee T, Rosenheck R. Association of Recent and Past Homelessness with Health-Related Quality of Life among US Adults. Psychiatric Quarterly 2026, 1-19. PMID: 41758416, DOI: 10.1007/s11126-026-10258-7.
Peer-Reviewed Original Research
Concepts
Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD
Jones A, Warner-Schmidt J, Kwak H, Stogniew M, Mandell B, Ching T, Stein M, Kelmendi B. Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD. JAMA Psychiatry 2026, 83 PMID: 41706459, PMCID: PMC12917749, DOI: 10.1001/jamapsychiatry.2025.4625.
Peer-Reviewed Original Research
Concepts
Association of Multimodal Cannabis Use With Adverse Psychosocial Events Among Adolescents and Young Adults
Bommersbach T, Olfson M, Rhee T. Association of Multimodal Cannabis Use With Adverse Psychosocial Events Among Adolescents and Young Adults. American Journal Of Preventive Medicine 2026, 71: 108313. PMID: 41698445, DOI: 10.1016/j.amepre.2026.108313.
Peer-Reviewed Original Research
Concepts
The effect of GLP-1 receptor agonists on autophagy: insights gathered from research evaluating neurodegenerative disorders with these agents
Sioufi M, Heroiu I, Wong S, Le G, Dri C, Zheng Y, Teopiz K, Rhee T, Lo H, Guillen-Burgos H, McIntyre R. The effect of GLP-1 receptor agonists on autophagy: insights gathered from research evaluating neurodegenerative disorders with these agents. Acta Neuropsychiatrica 2026, 38: e24. PMID: 41684077, DOI: 10.1017/neu.2026.10060.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Cardiac Consequences Associated with Psychedelic Use: A Systematic Review of Lysergic Acid Diethylamide, 3,4-Methylenedioxymethamphetamine, and 5-Hydroxytryptamine 2B-Mediated Valvular Heart Disease
Xu T, Wong S, Le G, Dri C, Teopiz K, Lu A, Lee S, Rhee T, Yin L, Bargiota S, Ho R, McIntyre R. Cardiac Consequences Associated with Psychedelic Use: A Systematic Review of Lysergic Acid Diethylamide, 3,4-Methylenedioxymethamphetamine, and 5-Hydroxytryptamine 2B-Mediated Valvular Heart Disease. Pharmacopsychiatry 2026, 59: 74-87. PMID: 41643722, DOI: 10.1055/a-2794-6487.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Efficacy of MAO-B and COMT inhibitors on quality of life in patients with Parkinson’s disease: a Bayesian network meta-analysis
Shim S, Jung Y, Kwon K, Rhee T, Lee S. Efficacy of MAO-B and COMT inhibitors on quality of life in patients with Parkinson’s disease: a Bayesian network meta-analysis. Frontiers In Neurology 2026, 17: 1753555. PMID: 41716552, PMCID: PMC12913192, DOI: 10.3389/fneur.2026.1753555.
Peer-Reviewed Original Research
Concepts
Interpreting the Signal Beyond the Trend: Response to Hanyu
Bommersbach T, Olfson M, Rhee T. Interpreting the Signal Beyond the Trend: Response to Hanyu. American Journal Of Psychiatry 2026, 183: 145-146. PMID: 41620814, DOI: 10.1176/appi.ajp.20251328.
Peer-Reviewed Original Research
Is the antidepressant efficacy of ketamine and esketamine mediated via opioid mechanisms?
Lu A, Xu H, Le G, Dri C, Wong S, Ho R, Cao B, Lo H, Rhee T, Yin L, Guillen-Burgos H, McIntyre R. Is the antidepressant efficacy of ketamine and esketamine mediated via opioid mechanisms? European Psychiatry 2026, 69: e24. PMID: 41607072, PMCID: PMC12925689, DOI: 10.1192/j.eurpsy.2026.10157.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012-2024.
Havlik J, Isaac S, Radovan C, Ostacher M, Smith D, Rhee T. Innovation in Psychiatric Drug Development: A Quantitative Analysis of FDA-Approved Psychiatric Drugs, 2012-2024. The Journal Of Clinical Psychiatry 2026, 87 PMID: 41532845, DOI: 10.4088/jcp.25m16063.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

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