Wei Zheng
Associate Research ScientistAbout
Research
Publications
2026
African ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women
Jia G, Liu L, Ping J, Fiorica P, Guo X, Tao R, Li B, Gu J, John E, Olopade O, Press M, Brewster A, Olshan A, Zirpoli G, Butler E, Huang M, Huo D, Palmer J, Haiman C, Ambrosone C, Troester M, Long J, Yao S, Zheng W. African ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women. Genome Medicine 2026 PMID: 42098873, DOI: 10.1186/s13073-026-01665-3.Peer-Reviewed Original ResearchAfrican American womenTriple-negative breast cancerCase-control analysisAmerican womenTriple-negative breast cancer casesTriple-negative breast cancer riskER-positive casesAfrican ancestryBreast cancer geneticsRisk variantsBreast cancer susceptibilityAllelic odds ratioAssociation analysisBreast cancerRisk allele frequenciesProportion of African ancestryBody mass indexAssociated with triple-negative breast cancerAssociated with TNBC riskEstrogen receptor (ER)-positive casesER-positive breast cancerAssociation of African ancestryEuropean American womenStatistically significant associationGenetic factorsLead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve
Khandokar L, Liu L, Zheng W, Kerstein P. Lead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve. NeuroToxicology 2026, 114: 103461. PMID: 42034125, DOI: 10.1016/j.neuro.2026.103461.Peer-Reviewed Original ResearchChoroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles
Liu L, Shannahan J, Zheng W. Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles. Fluids And Barriers Of The CNS 2026, 23: 50. PMID: 41917944, PMCID: PMC13045046, DOI: 10.1186/s12987-026-00793-7.Peer-Reviewed Original ResearchEstrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies
Yuan F, Shu X, Long J, Huang W, Lipworth L, Xu X, Khankari N, Watts E, Tao R, Cai H, Moore S, Zheng W. Estrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies. Cancer Prevention Research 2026, of1-of10. PMID: 41883178, PMCID: PMC13084517, DOI: 10.1158/1940-6207.capr-25-0382.Peer-Reviewed Original ResearchRisk of postmenopausal breastLifestyle scoreRisk of breastPostmenopausal breastCancer riskLifestyle patternsShanghai Women's Health StudyLifestyle modificationHazard ratioLow riskOvarian Screening TrialLower risk of breastBreast cancer riskEndometrial cancer riskWomen's Health StudyConfidence intervalsEstrogen metabolitesPostmenopausal womenOvarian cancerEndometrial cancerProspective cohort studyCox proportional hazards modelsEtiology of hormone-related cancersER-negative breast cancerHormone-related cancersA reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case–control analysis
Chang X, Mariapun S, Li M, Wang L, Ho P, Khng A, Muir K, Lophatananon A, Aronson K, Murphy R, Kwong A, Au C, Kim S, Park S, Stram D, Wu A, Teo S, Yip C, Tai N, Investigators M, John E, Kurian A, Iwasaki M, Yamaji T, Choi J, Kang D, Shu X, Zheng W, Hartman M, Tan E, Tan V, Lim G, Bolla M, Dunning A, Dennis J, Wang Q, Naven M, Easton D, Consortium S, Dorajoo R, Ho W, Li J. A reanalysis of a genome-wide association study on breast cancer in Asian populations using the SG10K_Health reference panel for imputation: a multi-Centre case–control analysis. Human Molecular Genetics 2026, 35: ddag015. PMID: 41871294, PMCID: PMC13017919, DOI: 10.1093/hmg/ddag015.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosis Regulatory ProteinsAsian PeopleBreast NeoplasmsCase-Control StudiesEstrogen Receptor alphaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 2Receptors, ProgesteroneTrans-ActivatorsConceptsGenome-wide association studiesReference panelBreast Cancer Association ConsortiumAssociation studiesBreast cancer riskImputation reference panelAsian populationsCase-control analysisCancer riskVariant discoveryCandidate lociImputation panelAssociation signalsCase-controlRare allelesVariant detectionGenetic variantsRare variantsBreast cancerEuropean populationsCancer datasetsBreastBreast cancer datasetVariantsSG10Deep Learning-Guided Discovery of Dual Inhibitors of SARS-CoV-2 Entry and 3CL Protease
Gao P, Pavlinov I, Xu M, Chen C, Vasquez D, Zhang Q, Ye Y, Martinez-Sobrido L, Zheng W, Shen M. Deep Learning-Guided Discovery of Dual Inhibitors of SARS-CoV-2 Entry and 3CL Protease. Molecules 2026, 31: 1043. PMID: 41900142, DOI: 10.3390/molecules31061043.Peer-Reviewed Original ResearchConceptsMolecular docking studiesMolecular dynamics simulationsSARS-CoV-2 inhibitorsChemically diverse scaffoldsDual-target inhibitionIn-house collectionEvolution of severe acute respiratory syndrome coronavirus 2Protease active siteDiverse scaffoldsDocking studiesBinding modeSARS-CoV-2 entryNovel hitsDynamics simulationsActive siteInhibitors of SARS-CoV-2 entryHost interactionsModerate potencyGraph convolutional networkSARS-CoV-2Sulfate interactionAntiviral strategiesViral mechanismsConvolutional networkProteaseCirculating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study
Zheng Y, Yang J, Gupta D, Herrington D, Yu B, Nguyen N, Pinto R, Tzoulaki I, Cai H, Cai Q, Lipworth L, Shu X, Zheng W, Yu D. Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study. PLOS Medicine 2026, 23: e1004750. PMID: 41843497, PMCID: PMC12994840, DOI: 10.1371/journal.pmed.1004750.Peer-Reviewed Original ResearchConceptsIncident coronary heart diseaseBody mass indexCoronary heart diseaseFollow-up timeOdds ratioMulti-Ethnic StudyShanghai Women's Health StudyHeart diseaseShanghai Men's Health StudyMetabolic disease historyHealth StudyAssociated with incident coronary heart diseaseMicrobial metabolitesWomen's Health StudySouthern Community Cohort StudyPlasma metabolite profilesCoronary heart disease developmentMen's Health StudyRisk of coronary heart diseaseConditional logistic regressionHuman cardiometabolic healthMulti-Ethnic Study of AtherosclerosisCommunity Cohort StudyGut microbial metabolismCoronary heart disease diagnosisHigh-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression
Sahin G, Guyett P, Xu K, Kouznetsova J, Zheng W, Hendrickson M. High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression. SLAS DISCOVERY 2026, 40: 100303. PMID: 41839426, DOI: 10.1016/j.slasd.2026.100303.Peer-Reviewed Original ResearchInduced pluripotent stem cellsSpinal motor neuronsTGF-b signalingMotor neuronsAmyotrophic lateral sclerosisTGF-bHigh-throughput screeningLight chain expressionFDA-approved treatmentIn vivo drug metabolismAmyotrophic lateral sclerosis patientsIPSC-derived motor neuronsPluripotent stem cellsNeurofilament light chainIPSC-derived neuronsChain expressionSubunit expressionSpinal cordNF-L expressionCell-based reporter systemALS patientsStem cellsDrug metabolismPathology of amyotrophic lateral sclerosisNeuronsEstrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies.
Yuan F, Shu X, Long J, Huang W, Lipworth L, Xu X, Khankari N, Watts E, Tao R, Cai H, Moore S, Zheng W. Estrogen metabolism-related lifestyle score and risk of postmenopausal breast, endometrial, and ovarian cancers: findings from two large prospective cohort studies. Cancer Prevention Research 2026, of1-of10. PMID: 41808586, DOI: 10.1158/1940-6207.capr-25-0382.Peer-Reviewed Original ResearchRisk of postmenopausal breastLifestyle scoreAssociated with lower riskRisk of breastPostmenopausal breastLifestyle patternsShanghai Women's Health StudyEstrogen metabolitesHazard ratioOvarian Screening TrialLower risk of breastWomen's Health StudyConfidence intervalsOvarian cancerEndometrial cancerParent estrogensEtiology of hormone-related cancersProspective cohort studyER-negative breast cancerEstrogen receptor (ER)-positiveLow riskCox proportional hazards modelsHormone-related cancersProportional hazards modelHealth StudyGeneration and characterization of induced pluripotent stem cell (iPSC) lines from patients affected with Tay-Sachs and Sandhoff disease
Jovanovic V, Chen C, Toro C, Hurd K, Zou J, Tifft C, Zheng W, Henderson M, Marugan J, Tristan C. Generation and characterization of induced pluripotent stem cell (iPSC) lines from patients affected with Tay-Sachs and Sandhoff disease. Stem Cell Research 2026, 92: 103949. PMID: 41795546, DOI: 10.1016/j.scr.2026.103949.Peer-Reviewed Original ResearchConceptsHEXB geneTay-SachsBeta subunitLysosomal storage disease modelsSandhoff diseaseHeterozygous mutationsTay-Sachs patientsIPSC linesComplex heterozygous mutationHEXA geneSandhoff patientsTherapeutic drug developmentPluripotent stem cellsLate-onset diseaseGenesMutationsHEXBGenetic mutationsLysosomal hexosaminidasesSandhoffPatientsStem cellsDrug developmentDisease modelsDisease
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