David Meseguer Garcia
he/him/his
Graduate StudentAbout
Research
Publications
2026
Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked J, Page K, Barrows D, Carroll T, Grajales-Reyes J, Na D, Rodriguez-Diaz A, Furtado J, Isaza J, Schiffer H, Chen Y, Sun H, Kaushal N, Monenschein H, Barker D, Ortuño M, Renier N, Cohen P, Carlton M, Heintz N, Brice N, Friedman J, Schneeberger M. Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice. Nature Communications 2026, 17: 1295. PMID: 41530127, PMCID: PMC12868712, DOI: 10.1038/s41467-025-68056-x.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusRaphe nucleusChronic inhibitionMale miceInhibition of GABAergic neuronsSustained weight lossVentrolateral periaqueductal grayIn situ hybridizationHigh-fat dietGABAergic neuronsCounterregulatory mechanismsBrown adipose tissue thermogenesisAdipose tissue thermogenesisGenetic predispositionPeriaqueductal greyDiet-inducedMolecular profilingHigh-throughput drug screeningMetabolic phenotypeWeight managementInverse agonistsWeight lossHuman brainMiceBody weight
2024
Rewiring of the glymphatic landscape in metabolic disorders
Chen B, Meseguer D, Lenck S, Thomas J, Schneeberger M. Rewiring of the glymphatic landscape in metabolic disorders. Trends In Endocrinology And Metabolism 2024, 36: 710-720. PMID: 39638721, PMCID: PMC12134147, DOI: 10.1016/j.tem.2024.11.005.Peer-Reviewed Original ResearchMetabolic dysfunctionNeurological disordersBlood-brain barrier leakageCerebral blood flow disruptionBlood flow disruptionGlymphatic systemTreatment strategiesCognitive declineRisk factorsMetabolic disordersNeurovascular uncouplingBarrier leakageGlymphatic clearance systemMetabolic diseasesDisordersObesityDysfunctionThe interactions between energy homeostasis and neurovascular plasticity
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 20: 749-759. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.Peer-Reviewed Original ResearchWestern dietLifestyle interventionNeurovascular systemCurrent obesity epidemicEnergy homeostasisStable body weightLocal neuronal networksRegulate energy balanceNeuronal networksFood intakeObesity epidemicSedentary lifestylePharmacological interventionsNeurovascular plasticityOverall healthNutritional milieuWeight lossLong-term needsCardiovascular systemBody weightEnergy expenditureAdverse effectsBrain centresLifestyleBrain vasculatureHydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice
Qi Q, Zhang H, Jin Z, Wang C, Xia M, Chen B, Lv B, Peres Diaz L, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L, Schneeberger M, Yu X. Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice. Nature Metabolism 2024, 6: 1601-1615. PMID: 39030389, DOI: 10.1038/s42255-024-01068-x.Peer-Reviewed Original ResearchConceptsHost metabolismGLP-1 productionGut microbiotaUnfolded protein responseMicrobiota-derived metabolitesIntestinal L cellsInhibit mitochondrial respirationDiet-induced metabolic disordersGut hormone glucagon-like peptide 1Hormone glucagon-like peptide 1Intestinal symbiontsProtein responseGLP-1Male miceGLP-1 secretionMitochondrial respirationGene expressionL cellsGutGlucagon-like peptide 1Production of hydrogen sulfideMicrobiotaPathogenesis of metabolic syndromeGLP-1 levelsDesulfovibrioBurning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?
Grajales-Reyes J, Chen B, Meseguer D, Schneeberger M. Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? Physiology 2024, 39: 218-230. PMID: 38536114, PMCID: PMC11368520, DOI: 10.1152/physiol.00034.2023.Peer-Reviewed Original Research
2023
Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain.
Cuitavi J, Andrés-Herrera P, Meseguer D, Campos-Jurado Y, Lorente JD, Caruana H, Hipólito L. Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain. Glia 2023, 71: 1906-1920. PMID: 37017183, DOI: 10.1002/glia.24374.Peer-Reviewed Original ResearchDynamic rewiring of neurovasculature in health and disease
Chen B, Meseguer D, Renier N, Schneeberger M. Dynamic rewiring of neurovasculature in health and disease. Trends In Molecular Medicine 2023, 29: 786-788. PMID: 37487781, PMCID: PMC10528198, DOI: 10.1016/j.molmed.2023.06.011.Peer-Reviewed Original Research