Research in the Kim Lab centers on uncovering the molecular mechanisms that govern the controlled reactivation of early developmental programs to trigger epigenetic rejuvenation and restore or induce regenerative potential. Our overarching goal is to develop innovative therapeutic strategies that guide cell fate decisions—and their reversal—in the context of cardiovascular and age-related diseases.
Vascular Aging and Regeneration
Primary Faculty
The overarching goal of the Kyriakides Lab is the creation of novel regenerative medicine strategies to enhance tissue repair. The lab investigates the regulation and function of matricellular proteins in extracellular matrix remodeling, inflammation, angiogenesis, wound healing, and the foreign body response.
The Raredon Laboratory studies cell-to-cell signaling mechanisms governing multicellular systems, and engineers specialized bioinformatics approaches to design regenerative therapies for vascularized living tissues. We have a particular interest in understanding and influencing the self-organization of alveolar tissue within the diseased and regenerating lung.
Affiliated Faculty
Professor of Pathology
The Braddock Lab’s focus is the study severe poorly addressed human disease with an emphasis on the elucidation of disease pathogenesis to unveil therapeutic targets. The laboratory is particularly interested in rare diseases of children, and in the design and engineering of novel biologics to modulate disease outcome. He is the scientific founder of Inozyme, whose lead asset, which was developed in Dr. Braddock’s lab, is now in phase 3 clinical trials in two lead indications.
Associate Professor of Biomedical Engineering and of Immunobiology
Our lab’s focus is two-fold: 1) biomaterials for drug and antigen delivery to the immune system 2) development of novel MRI contrast agents for detection of specific T cells and antigen-presenting cells.
Raymond John Wean Professor of Biomedical Engineering; Affiliated Faculty, Vascular Biology and Therapeutics Program; Affiliated Faculty, Yale Institute for Global Health; Faculty Director, Tsai Center for Innovative Thinking at Yale (Tsai City); Head of College, Davenport College
My lab is developing human mimetic biomaterial-based constructs for use in studying immunological responses to injury and inflammatory signals. The results of this work expands our fundamental understanding of microvascular and tissue homeostasis in lung, skin, and brain, with applications in wound healing, fibrosis, and stroke.
John C. Malone Professor of Biomedical Engineering; Department Chair, Biomedical Engineering
Investigating aortic and pulmonary artery development, aging, and tissue engineering as well as arterial disease progression, particularly aortopathy and hypertension.
Professor of Surgery (Transplant); Surgical Director of Kidney Transplantation, Yale-New Haven Hospital ; Physician Executive Director, Clinical Continuity & Integration, Yale-New Haven Hospital, Yale-New Haven Hospital; Medical Director, New England Donor Services, New England Donor Services
Living kidney donation has been a primary clinical and academic interest in my career. We have completed a prospective, multi-center study of 307 living kidney donors, this study looks at an individuals' perception of living a donation, their risk tolerance, and if relationship closeness impacts a donor's willingness to take risks.
Assistant Professor
Our lab studies the role of blood and lymphatic endothelial cells in intestinal regeneration inflammatory bowel disease, and nutrient absorption. We utilize mouse genetic models, human tissue, vascularized organoid models and transcriptomic analyses, to uncover mechanisms that can be leveraged to drive regeneration on demand for precision medicine.
Frank F. Kanthak Professor of Surgery (Plastics); Chief, Plastic & Reconstructive Surgery; Professor, Surgery
My laboratory focuses on advancing the field of facial vascularized composite allotransplantation (fVCA) by investigating mechanisms of acute and chronic rejection, including the roles of cellular and antibody-mediated immunity, donor-specific antibodies, and mucosal versus cutaneous tissue monitoring. Additionally, we explore innovative preservation strategies for vascularized composite allografts, such as normothermic ex-situ perfusion, to improve graft viability and reduce ischemia-reperfusion injury.
Professor of Medicine (Cardiovascular Medicine); Section of Cardiovascular Medicine
Our stem cell and regenerative medicine laboratory focuses on establishing novel cellular, tissue engineered, and animal models of human cardiovascular diseases for the purpose of elucidating causative mechanisms and identifying therapeutic interventions to treat these diseases.
Sterling Professor of Biomedical Engineering and Professor of Cellular and Molecular Physiology and of Chemical Engineering; Affiliated Faculty, Yale Institute for Global Health; Department Chair, Biomedical Engineering
My laboratory is studying the creation and use of polymer biomaterials, with a particular interest in targeting therapies to vascular endothelial cells and promoting vascularization of engineered tissues.