The Hidalgo lab is interested in defining how innate immune cells adapt to and promote health or disease, with a particular focus on neutrophils and macrophages. We study the mechanisms of this adaptation and harness this knowledge to improve health. We use imaging, single-cell omics, and computational analyses in mouse models of cancer and cardiovascular disease.
Immunobiology and Metabolism in CVD
Primary Faculty
I am a physician-scientist, and my research lab uses patient-centered approaches to understand immune mechanisms of transplant rejection.
The Koh Lab investigates specialized stem cell microenvironments, with a particular focus on vasculature, in various craniofacial bones to find novel cellular/molecular targets to drive stem cell fate. We utilize state-of-the-art imaging methods and innovative functional assays to explore novel bone marrow niches and understand their distinct contribution to fundamental physiological processes, such as brain function, immunity, and regeneration.
The Libreros Lab aims to elucidate the biochemical, immunological, and molecular mechanisms that orchestrate the resolution of inflammation to restore organ-specific and systemic homeostasis following pathological insults, and to define how disruptions in these regulatory circuits contribute to the development of chronic inflammation.
We study human immune-mediated mechanisms of vascular and tissue injury with a focus on lymphocyte interactions with endothelial, stromal or epithelial cells. We also explore approaches to limit immune-mediated tissue damage.
My laboratory investigates novel regulatory mechanisms governing endothelial cell and macrophage functions, highlighting their critical interplay in angiogenic and inflammatory responses within atherosclerosis, tumor growth, and other pathophysiological conditions.
My laboratory has been studying various signaling pathways, including Wnt and GPCR-coupled ones, for their roles in leukocyte functions with emphasis on inflammation, tissue injuries, and tumor immunology.
Affiliated Faculty
My laboratory has had a longstanding interest in interactions between mononuclear leukocytes and endothelial cells play major roles in atherogenesis, acute and chronic manifestations of atherosclerosis, angiogenesis and allograft rejection. We have extended these studies to evaluating effects of ovarian steroid hormones on endothelial function.
The focus of the research in this laboratory is to understand how protein tyrosine phosphatases function in the control of normal cellular physiology. The ultimate goal of our research on protein tyrosine phosphatases is to establish whether these enzymes participate in disease processes such as cancer, cardiovascular disease, diabetes and rare diseases.
The research goals of the lab are to characterize the development and function of regulatory T cells and characterize mechanisms that affect autoimmunity, inflammation, transplantation and recruitment into vascular sites. In addition, our experience with synthetic microvessels has lead to a translational project to revascularize islets to treat type I diabetes.
My laboratory studies signaling by integrin adhesion receptors with a focus on their interactions with the actin cytoskeleton. We are also interested in how disruption of CCM protein complexes alters cell signaling leading to cerebral cavernous malformations.
The Hwa lab studies how platelets respond to blood stressors (e.g. hyperglycemia, inflammation) and transduces the stressor (e.g. unfolded protein response) into a cellular response (e.g. activation). This response is then communicated to other platelets or other cells (e.g. T cells).
Our lab studies the vascular and lymphatic systems of the liver to understand their roles in liver fibrosis, cirrhosis and portal hypertension. We aim to uncover mechanisms of endothelial dysfunction and identify new therapeutic targets for chronic liver disease.
The goal of the Krause Laboratory is to define how stem and progenitor cells balance and regulate fate decisions in health and disease. We study stem cells to improve strategies for repair and regeneration of the hematopoietic system as well as solid organs including the lung and parathyroids.
Our lab studies how Weibel-Palade body, the specialized endothelial secretory granule containing plasma hemostatic glycoprotein von Willebrand factor (vWF), is formed, and how vWF release is regulated. Our goal is to develop novel therapies to modulate plasma vWF in conditions such as von Willebrand disease, a common bleeding disorder. In addition, our lab is investigating mechanisms of immunothrombosis in disorders such as antiphospholipid syndrome.
The Young laboratory investigates the interface or metabolism and myocardial disease, integrating metabolic, molecular and physiological techniques. We have pioneered studies of the role of AMP-activated protein kinase in ischemia, heart failure and arrhythmia.