Publications

Explore Yale Legacy Collaborative scientific findings that have been published in peer-reviewed, academic journals. The following is a select few in descending publication date order. View the full 149 publications on PubMed.

Select Listings

Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity.Galuppo B, Mannam P, Bonet J, Pierpont B, Trico' D, Haskell-Luevano C, Ericson MD, Freeman KT, Philbrick WM, Bale AE, Caprio S, Santoro N. Int J Obes (Lond). 2025 May; 2024 Dec 29. PMID: 39738493.
Overview of the Treatment of Pediatric Obesity and the 2023 Clinical Practice Guidelines.Hu P, Samuels S, Sharifi M. Pediatr Clin North Am. 2024 Oct; 2024 Jul 23. PMID: 39343501.
Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity.Tricò D, Chiriacò M, Nouws J, Vash-Margita A, Kursawe R, Tarabra E, Galderisi A, Natali A, Giannini C, Hellerstein M, Ferrannini E, Caprio S. Diabetes. 2024 Jun 1. PMID: 37870826.
Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity.Slusher AL, Nouws J, Tokoglu F, Vash-Margita A, Matthews MD, Fitch M, Shankaran M, Hellerstein MK, Caprio S. Obesity (Silver Spring). 2024 Mar. PMID: 38410080.
Quantifying beta cell function in the preclinical stages of type 1 diabetes.Galderisi A, Carr ALJ, Martino M, Taylor P, Senior P, Dayan C. Diabetologia. 2023 Dec; 2023 Sep 15. PMID: 37712956.
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity.Galderisi A, Tricò D, Lat J, Samuels S, Weiss R, Van Name M, Pierpont B, Santoro N, Caprio S. JCI Insight. 2023 Nov 22; 2023 Nov 22. PMID: 37847560.
High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities.Bloyd M, Sinaii N, Faucz FR, Iben J, Coon SL, Caprio S, Santoro N, Stratakis CA, London E. Front Endocrinol (Lausanne). 2023; 2023 Nov 13. PMID: 38027204.
Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes.Tryggestad JB, Drews KL, Mele L, Arslanian S, Chernausek SD, Escaname EN, Geffner M, Isganaitis E, Sprague J, Kelsey MM. Diabetes Res Clin Pract. 2023 Sep; 2023 Aug 16. PMID: 37595843.
Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high-density lipoprotein cholesterol ratio in youths.Chiriacò M, Nesti L, Natali A, Santoro N, Caprio S, Tricò D. Obesity (Silver Spring). 2023 Jul; 2023 May 25. PMID: 37227148.
Rising NAFLD and metabolic severity during the Sars-CoV-2 pandemic among children with obesity in the United States.Slusher AL, Hu P, Samuels S, Tokoglu F, Lat J, Li Z, Alguard M, Strober J, Vatner D, Shabanova V, Caprio S. Obesity (Silver Spring). 2023 May. PMID: 36694381.
Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents.Halloun R, Galderisi A, Caprio S, Weiss R. J Clin Endocrinol Metab. 2023 Apr 13. PMID: 36469736.
Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications.Shah RD, Chernausek SD, El Ghormli L, Geffner ME, Keady J, Kelsey MM, Farrell R, Tesfaldet B, Tryggestad JB, Van Name M, Isganaitis E. J Clin Endocrinol Metab. 2023 Apr 13. PMID: 36446741.
Insulin Clearance in Health and Disease.Najjar SM, Caprio S, Gastaldelli A. Annu Rev Physiol. 2023 Feb 10; 2022 Oct 19. PMID: 36260807.
Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms.Cassin J, Stamou MI, Keefe KW, Sung KE, Bojo CC, Tonsfeldt KJ, Rojas RA, Ferreira Lopes V, Plummer L, Salnikov KB, Keefe DL Jr, Ozata M, Genel M, Georgopoulos NA, Hall JE, Crowley WF Jr, Seminara SB, Mellon PL, Balasubramanian R. JCI Insight. 2023 Feb 8; 2023 Feb 8. PMID: 36602867.
Identification of a novel link between adiposity and visuospatial perception.Chen HA, Hovens IB, Davis XS, Hutelin Z, Wall KM, Small DM. Obesity (Silver Spring). 2023 Feb; 2022 Dec 22. PMID: 36546337.
The role of oxidized lipid species in insulin resistance and NASH in children.Santoro N, Feldstein AE. Front Endocrinol (Lausanne). 2022; 2022 Oct 3. PMID: 36263326.
Understanding the Pathophysiology of Youth-Onset Type 2 Diabetes (T2D): Importance of Alpha-Cell Function.Lat J, Caprio S. J Clin Endocrinol Metab. 2022 Aug 18. PMID: 35512384.
Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach.Tricò D, McCollum S, Samuels S, Santoro N, Galderisi A, Groop L, Caprio S, Shabanova V. Diabetes Care. 2022 Aug 1. PMID: 35766976.
IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans.Pearson JA, Ding H, Hu C, Peng J, Galuppo B, Wong FS, Caprio S, Santoro N, Wen L. Diabetologia. 2022 Aug; 2022 May 19. PMID: 35587276.
Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease.Yao K, Tarabra E, Sia D, Morotti R, Fawaz R, Valentino P, Santoro N, Caprio S, Liu S, Yimlamai D. Hepatol Commun. 2022 Jul; 2022 Mar 21. PMID: 35312185.
A low n-6 to n-3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth.Tricò D, Galderisi A, Van Name MA, Caprio S, Samuels S, Li Z, Galuppo BT, Savoye M, Mari A, Feldstein AE, Santoro N. Diabetes Obes Metab. 2022 Jul; 2022 Apr 18. PMID: 35297549.
Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study.Halloun R, Galderisi A, Caprio S, Weiss R. Diabetes Care. 2022 Jun 2. PMID: 35235641.
Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study.Shah AS, Gidding SS, El Ghormli L, Tryggestad JB, Nadeau KJ, Bacha F, Levitt Katz LE, Willi SM, Lima J, Urbina EM. J Am Soc Echocardiogr. 2022 Jun; 2022 Feb 8. PMID: 35149207.
Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity.Galuppo B, Agazzi C, Pierpont B, Chick J, Li Z, Caprio S, Santoro N. Nutr Diabetes. 2022 Feb 22; 2022 Feb 22. PMID: 35194014.
Relation of glomerular filtration to insulin resistance and related risk factors in obese children.Magen D, Halloun R, Galderisi A, Caprio S, Weiss R. Int J Obes (Lond). 2022 Feb; 2021 Nov 1. PMID: 34725443.
CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution.Tarabra E, Nouws J, Vash-Margita A, Hellerstein M, Shabanova V, McCollum S, Pierpont B, Zhao D, Shulman GI, Caprio S. Obesity (Silver Spring). 2021 Dec; 2021 Oct 21. PMID: 34672413.
Early Impairment of Insulin Sensitivity, β-Cell Responsiveness, and Insulin Clearance in Youth with Stage 1 Type 1 Diabetes.Galderisi A, Moran A, Evans-Molina C, Martino M, Santoro N, Caprio S, Cobelli C. J Clin Endocrinol Metab. 2021 Aug 18. PMID: 34000022.
Long-Term Complications in Youth-Onset Type 2 Diabetes.Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler P. N Engl J Med. 2021 Jul 29. PMID: 34320286.
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.Teo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P, Berg T, Bhatnagar P, Buch S, Canbay A, Caprio S, Chatterjee A, Ida Chen YD, Chowdhury A, Daly AK, Datz C, de Gracia Hahn D, DiStefano JK, Dong J, Duret A, Emdin C, Fairey M, Gerhard GS, Guo X, Hampe J, Hickman M, Heintz L, Hudert C, Hunter H, Kelly M, Kozlitina J, Krawczyk M, Lammert F, Langenberg C, Lavine J, Li L, Lim HK, Loomba R, Luukkonen PK, Melton PE, Mori TA, Palmer ND, Parisinos CA, Pillai SG, Qayyum F, Reichert MC, Romeo S, Rotter JI, Im YR, Santoro N, Schafmayer C, Speliotes EK, Stender S, Stickel F, Still CD, Strnad P, Taylor KD, Tybjærg-Hansen A, Umano GR, Utukuri M, Valenti L, Wagenknecht LE, Wareham NJ, Watanabe RM, Wattacheril J, Yaghootkar H, Yki-Järvinen H, Young KA, Mann JP. J Hepatol. 2021 Jan; 2020 Aug 31. PMID: 32882372.
Glutamate-Serine-Glycine Index: A Novel Potential Biomarker in Pediatric Non-Alcoholic Fatty Liver Disease.Leonetti S, Herzog RI, Caprio S, Santoro N, Tricò D. Children (Basel). 2020 Dec 4; 2020 Dec 4. PMID: 33291552.
A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth.Galderisi A, Tricò D, Pierpont B, Shabanova V, Samuels S, Dalla Man C, Galuppo B, Santoro N, Caprio S. Diabetes Care. 2020 Oct; 2020 Aug 11. PMID: 32788279.
Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross-sectional and longitudinal study from the Yale Pediatric NAFLD cohort.Tricò D, Galderisi A, Mari A, Polidori D, Galuppo B, Pierpont B, Samuels S, Santoro N, Caprio S. Diabetes Obes Metab. 2020 Sep; 2020 May 31. PMID: 32363679.
Identification of a brain fingerprint for overweight and obesity.Farruggia MC, van Kooten MJ, Perszyk EE, Burke MV, Scheinost D, Constable RT, Small DM. Physiol Behav. 2020 Aug 1; 2020 May 14. PMID: 32417645.
Hepatic fat is a stronger correlate of key clinical and molecular abnormalities than visceral and abdominal subcutaneous fat in youth.Cioffi CE, Narayan KMV, Liu K, Uppal K, Jones DP, Tran V, Yu T, Alvarez JA, Bellissimo MP, Maner-Smith KM, Pierpoint B, Caprio S, Santoro N, Vos MB. BMJ Open Diabetes Res Care. 2020 Jul. PMID: 32699106.
The omentum of obese girls harbors small adipocytes and browning transcripts.Tarabra E, Nouws J, Vash-Margita A, Nadzam GS, Goldberg R, Van Name M, Pierpont B, Knight JR, Shulman GI, Caprio S. JCI Insight. 2020 Mar 26; 2020 Mar 26. PMID: 32125283.
Childhood obesity and the associated rise in cardiometabolic complications.Caprio S, Santoro N, Weiss R. Nat Metab. 2020 Mar; 2020 Mar 16. PMID: 32694781.
Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. J Clin Endocrinol Metab. 2020 Feb 1. PMID: 31972003.
A Brief Neuropsychological Battery for Measuring Cognitive Functions Associated with Obesity.Hovens IB, Dalenberg JR, Small DM. Obesity (Silver Spring). 2019 Dec; 2019 Oct 25. PMID: 31654505.
Lower Insulin Clearance Parallels a Reduced Insulin Sensitivity in Obese Youths and Is Associated With a Decline in β-Cell Function Over Time.Galderisi A, Polidori D, Weiss R, Giannini C, Pierpont B, Tricò D, Caprio S. Diabetes. 2019 Nov; 2019 Aug 9. PMID: 31399433.
Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics.Khusial RD, Cioffi CE, Caltharp SA, Krasinskas AM, Alazraki A, Knight-Scott J, Cleeton R, Castillo-Leon E, Jones DP, Pierpont B, Caprio S, Santoro N, Akil A, Vos MB. Hepatol Commun. 2019 Oct; 2019 Aug 13. PMID: 31592078.
Effects of adiposity and metabolic dysfunction on cognition: A review.Farruggia MC, Small DM. Physiol Behav. 2019 Sep 1; 2019 Jun 11. PMID: 31194997.
Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1-Mediated Mechanism.Galderisi A, Giannini C, Van Name M, Caprio S. J Clin Endocrinol Metab. 2019 Aug 1. PMID: 30938760.
Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls.Nouws J, Fitch M, Mata M, Santoro N, Galuppo B, Kursawe R, Narayan D, Vash-Margita A, Pierpont B, Shulman GI, Hellerstein M, Caprio S. Diabetes. 2019 Jun; 2019 Apr 1. PMID: 30936147.
One-hour post-load plasma glucose predicts progression to prediabetes in a multi-ethnic cohort of obese youths.Tricò D, Galderisi A, Mari A, Santoro N, Caprio S. Diabetes Obes Metab. 2019 May; 2019 Feb 28. PMID: 30663201.
A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study.Umano GR, Shabanova V, Pierpont B, Mata M, Nouws J, Tricò D, Galderisi A, Santoro N, Caprio S. Int J Obes (Lond). 2019 Apr; 2018 Oct 18. PMID: 30337653.
Relation of the degree of obesity in childhood to adipose tissue insulin resistance.Hagman E, Besor O, Hershkop K, Santoro N, Pierpont B, Mata M, Caprio S, Weiss R. Acta Diabetol. 2019 Feb; 2019 Jan 12. PMID: 30637483.
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?Tricò D, Di Sessa A, Caprio S, Chalasani N, Liu W, Liang T, Graf J, Herzog RI, Johnson CD, Umano GR, Feldstein AE, Santoro N. Antioxid Redox Signal. 2019 Jan 10; 2017 Apr 7. PMID: 28279074.
Predictors of responses to clinic-based childhood obesity care.Hagman E, Hecht L, Marko L, Azmanov H, Groop L, Santoro N, Caprio S, Weiss R. Pediatr Diabetes. 2018 Dec; 2018 Oct 1. PMID: 30225917.
Triglyceride-rich very low-density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents.Tricò D, Natali A, Mari A, Ferrannini E, Santoro N, Caprio S. Diabetes Obes Metab. 2018 Dec; 2018 Aug 2. PMID: 30003666.
Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis.Galderisi A, Giannini C, Weiss R, Kim G, Shabanova V, Santoro N, Pierpont B, Savoye M, Caprio S. Lancet Child Adolesc Health. 2018 Oct; 2018 Aug 24. PMID: 30236381.
Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort.Tricò D, Caprio S, Rosaria Umano G, Pierpont B, Nouws J, Galderisi A, Kim G, Mata MM, Santoro N. Hepatology. 2018 Oct. PMID: 29665034.
Phage treatment of an aortic graft infected with Pseudomonas aeruginosa.Chan BK, Turner PE, Kim S, Mojibian HR, Elefteriades JA, Narayan D. Evol Med Public Health. 2018; 2018 Mar 8. PMID: 29588855.
The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.Umano GR, Caprio S, Di Sessa A, Chalasani N, Dykas DJ, Pierpont B, Bale AE, Santoro N. Am J Gastroenterol. 2018 Mar; 2018 Feb 27. PMID: 29485130.
Impact of Severe Obesity on Cardiovascular Risk Factors in Youth.Zabarsky G, Beek C, Hagman E, Pierpont B, Caprio S, Weiss R. J Pediatr. 2018 Jan. PMID: 29246331.
Leptin Is Produced by Parathyroid Glands and Stimulates Parathyroid Hormone Secretion.Hoang D, Broer N, Sosa JA, Abitbol N, Yao X, Li F, Rivera-Molina F, Toomre DK, Roman SA, Sue G, Kim S, Li AY, Callender GG, Simpson C, Narayan D. Ann Surg. 2017 Dec. PMID: 27611607.
Prediabetes in youth - mechanisms and biomarkers.Weiss R, Santoro N, Giannini C, Galderisi A, Umano GR, Caprio S. Lancet Child Adolesc Health. 2017 Nov; 2017 Sep 26. PMID: 29075659.
The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.Cropano C, Santoro N, Groop L, Dalla Man C, Cobelli C, Galderisi A, Kursawe R, Pierpont B, Goffredo M, Caprio S. Diabetes Care. 2017 Aug; 2017 Jun 13. PMID: 28611053.
Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents.Tricò D, Prinsen H, Giannini C, de Graaf R, Juchem C, Li F, Caprio S, Santoro N, Herzog RI. J Clin Endocrinol Metab. 2017 Jul 1. PMID: 28482070.
A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease.Goffredo M, Santoro N, Tricò D, Giannini C, D'Adamo E, Zhao H, Peng G, Yu X, Lam TT, Pierpont B, Caprio S, Herzog RI. Nutrients. 2017 Jun 22; 2017 Jun 22. PMID: 28640216.
Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation.Caprio S, Perry R, Kursawe R. Gastroenterology. 2017 May; 2017 Feb 10. PMID: 28192105.
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N. Nat Commun. 2016 Aug 31; 2016 Aug 31. PMID: 27577745.
Adipose Insulin Resistance in Obese Adolescents Across the Spectrum of Glucose Tolerance.Hershkop K, Besor O, Santoro N, Pierpont B, Caprio S, Weiss R. J Clin Endocrinol Metab. 2016 Jun; 2016 Apr 7. PMID: 27054297.
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9.Garcia-Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, Shlomchik MJ, Coffman RL, Candia A, Mehal WZ. J Clin Invest. 2016 Mar 1; 2016 Jan 25. PMID: 26808498.
A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. Diabetes. 2016 Mar; 2015 Dec 30. PMID: 26718495.
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M. J Immunol. 2016 Jan 1; 2015 Nov 18. PMID: 26582949.
Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study.Goffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N. Hepatology. 2016 Jan; 2015 Nov 16. PMID: 26457389.
Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene.Santoro N, Caprio S, Pierpont B, Van Name M, Savoye M, Parks EJ. J Clin Endocrinol Metab. 2015 Aug; 2015 Jun 4. PMID: 26043229.
A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity.Zheng C, Dalla Man C, Cobelli C, Groop L, Zhao H, Bale AE, Shaw M, Duran E, Pierpont B, Caprio S, Santoro N. Obesity (Silver Spring). 2015 May. PMID: 25919927.
Glucose effectiveness in obese children: relation to degree of obesity and dysglycemia.Weiss R, Magge SN, Santoro N, Giannini C, Boston R, Holder T, Shaw M, Duran E, Hershkop KJ, Caprio S. Diabetes Care. 2015 Apr; 2015 Jan 29. PMID: 25633663.
Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance.Van Name M, Giannini C, Santoro N, Jastreboff AM, Kubat J, Li F, Kursawe R, Savoye M, Duran E, Dziura J, Sinha R, Sherwin RS, Cline G, Caprio S. Obesity (Silver Spring). 2015 Mar; 2015 Feb 3. PMID: 25645909.
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Cell. 2015 Feb 12; 2015 Feb 5. PMID: 25662011.
A low disposition index in adolescent offspring of mothers with gestational diabetes: a risk marker for the development of impaired glucose tolerance in youth.Holder T, Giannini C, Santoro N, Pierpont B, Shaw M, Duran E, Caprio S, Weiss R. Diabetologia. 2014 Nov; 2014 Aug 29. PMID: 25168408.
The development of type 2 diabetes in the obese adolescents: a growing challenge.Caprio S. Clin Biochem. 2014 Jun; 2014 May 20. PMID: 24854690.
The many faces of diabetes: a disease with increasing heterogeneity.Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L. Lancet. 2014 Mar 22; 2013 Dec 3. PMID: 24315621.
Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes.Giannini C, Dalla Man C, Groop L, Cobelli C, Zhao H, Shaw MM, Duran E, Pierpont B, Bale AE, Caprio S, Santoro N. Diabetes Care. 2014 Feb; 2013 Sep 23. PMID: 24062323.
Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents?Santoro N, Caprio S, Giannini C, Kim G, Kursawe R, Pierpont B, Shaw MM, Feldstein AE. Antioxid Redox Signal. 2014 Jan 10; 2013 Aug 3. PMID: 23815500.
Reliable Assessment of Insulin Resistance in Children.Van Name M, Caprio S. Curr Cardiovasc Risk Rep. 2013 Aug; 2013 Jun 5. PMID: 36845034.
Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage.Giannini C, Feldstein AE, Santoro N, Kim G, Kursawe R, Pierpont B, Caprio S. J Clin Endocrinol Metab. 2013 Jul; 2013 Apr 26. PMID: 23626003.
Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed.D'Adamo E, Santoro N, Caprio S. Curr Probl Pediatr Adolesc Health Care. 2013 May-Jun. PMID: 23582593.
The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants.Santoro N, Feldstein AE, Enoksson E, Pierpont B, Kursawe R, Kim G, Caprio S. Diabetes Care. 2013 May; 2012 Dec 28. PMID: 23275357.
Decreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia.Kursawe R, Caprio S, Giannini C, Narayan D, Lin A, D'Adamo E, Shaw M, Pierpont B, Cushman SW, Shulman GI. Diabetes. 2013 Mar; 2012 Dec 3. PMID: 23209190.
Progression of β-cell dysfunction in obese youth.Giannini C, Caprio S. Curr Diab Rep. 2013 Feb. PMID: 23179960.
Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth.Kim G, Giannini C, Pierpont B, Feldstein AE, Santoro N, Kursawe R, Shaw M, Duran E, Goldberg R, Dziura J, Caprio S. Diabetes Care. 2013 Jan; 2012 Aug 28. PMID: 22933439.
Islet function in obese adolescents.Giannini C, Caprio S. Diabetes Obes Metab. 2012 Oct. PMID: 22928563.
Development of type 2 diabetes mellitus in the obese adolescent: a growing challenge.Caprio S. Endocr Pract. 2012 Sep-Oct. PMID: 23047931.
Insulin resistance.Sinaiko AR, Caprio S. J Pediatr. 2012 Jul; 2012 Feb 14. PMID: 22336575.
Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study.Giannini C, Weiss R, Cali A, Bonadonna R, Santoro N, Pierpont B, Shaw M, Caprio S. Diabetes. 2012 Mar; 2012 Feb 7. PMID: 22315322.
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents.Santoro N, Zhang CK, Zhao H, Pakstis AJ, Kim G, Kursawe R, Dykas DJ, Bale AE, Giannini C, Pierpont B, Shaw MM, Groop L, Caprio S. Hepatology. 2012 Mar; 2011 Dec 18. PMID: 22105854.
Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake.Santoro N, Savoye M, Kim G, Marotto K, Shaw MM, Pierpont B, Caprio S. PLoS One. 2012; 2012 May 21. PMID: 22629460.
SirT1 regulates adipose tissue inflammation.Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. Diabetes. 2011 Dec. PMID: 22110092.
Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed.D'Adamo E, Santoro N, Caprio S. Pediatr Clin North Am. 2011 Oct. PMID: 21981958.
The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds.Giannini C, Santoro N, Caprio S, Kim G, Lartaud D, Shaw M, Pierpont B, Weiss R. Diabetes Care. 2011 Aug; 2011 Jul 5. PMID: 21730284.
Utility of hemoglobin A(1c) for diagnosing prediabetes and diabetes in obese children and adolescents.Nowicka P, Santoro N, Liu H, Lartaud D, Shaw MM, Goldberg R, Guandalini C, Savoye M, Rose P, Caprio S. Diabetes Care. 2011 Jun; 2011 Apr 22. PMID: 21515842.
Type 2 diabetes in youth: epidemiology and pathophysiology.D'Adamo E, Caprio S. Diabetes Care. 2011 May. PMID: 21525449.
Long-term results of an obesity program in an ethnically diverse pediatric population.Savoye M, Nowicka P, Shaw M, Yu S, Dziura J, Chavent G, O'Malley G, Serrecchia JB, Tamborlane WV, Caprio S. Pediatrics. 2011 Mar; 2011 Feb 7. PMID: 21300674.
A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Santoro N, Kursawe R, D'Adamo E, Dykas DJ, Zhang CK, Bale AE, Calí AM, Narayan D, Shaw MM, Pierpont B, Savoye M, Lartaud D, Eldrich S, Cushman SW, Zhao H, Shulman GI, Caprio S. Hepatology. 2010 Oct. PMID: 20803499.
Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis.Kursawe R, Narayan D, Cali AM, Shaw M, Pierpont B, Shulman GI, Caprio S. Obesity (Silver Spring). 2010 Oct; 2010 Feb 18. PMID: 20168312.
Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis.Kursawe R, Eszlinger M, Narayan D, Liu T, Bazuine M, Cali AM, D'Adamo E, Shaw M, Pierpont B, Shulman GI, Cushman SW, Sherman A, Caprio S. Diabetes. 2010 Sep. PMID: 20805387.
Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion.D'Adamo E, Northrup V, Weiss R, Santoro N, Pierpont B, Savoye M, O'Malley G, Caprio S. Am J Clin Nutr. 2010 Sep; 2010 Jun 23. PMID: 20573788.
Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents.D'Adamo E, Cali AM, Weiss R, Santoro N, Pierpont B, Northrup V, Caprio S. Diabetes Care. 2010 Aug. PMID: 20668154.

Publications

Select Listings

Participants in the Legacy Collaborative can email us with inquiries