Prateek Bhardwaj
Postdoctoral AssociateAbout
Research
Publications
2024
Paper-based point of care diagnostics for cancer biomarkers
Bhardwaj P, Arora B, Saxena S, Singh S, Palkar P, Goda J, Banerjee R. Paper-based point of care diagnostics for cancer biomarkers. Sensors & Diagnostics 2024, 3: 504-535. DOI: 10.1039/d3sd00340j.Peer-Reviewed Original ResearchPaper-based biosensorsDetection techniquesLow detection limitDetection i.Point-of-care systemLow-cost diagnosisManagement of cancerPoint of care diagnosticsUser-friendlyHome test kitsPatient survivalDetection of cancerAnalyte detectionDiagnosis of cancerDetection limitSignal transmissionSymptomatic detectionPaper chemistryTreatment opportunitiesCancerSignal amplificationAdvanced nanomaterialsEarly detectionCancer detectionClinical samples
2022
Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy
Bhardwaj P, Gota V, Vishwakarma K, Pai V, Chaudhari P, Mohanty B, Thorat R, Yadav S, Gurjar M, Goda JS, Banerjee R. Loco-regional radiosensitizing nanoparticles-in-gel augments head and neck cancer chemoradiotherapy. Journal Of Controlled Release 2022, 343: 288-302. PMID: 35101477, DOI: 10.1016/j.jconrel.2022.01.040.Peer-Reviewed Original Research
2021
Stimulus‐Responsive Nanoparticles for Therapeutic Stabilization of Atherosclerosis
Mehta S, Ahamad N, Dewani M, Bhardwaj P, Banerjee R. Stimulus‐Responsive Nanoparticles for Therapeutic Stabilization of Atherosclerosis. 2021, 181-215. DOI: 10.1002/9783527832095.ch7.ChaptersAtherosclerosis treatmentPlaque sitesNon-selective accumulationElevated enzyme levelsOff-target toxicityTherapeutic stabilizationFree drug deliveryCardiovascular complicationsBlood flowAtherosclerosisTherapeutic outcomesFirst lineOxidative stressArtery wallEnzyme levelsExogenous strategiesProgressive accumulationApparent toxicityCellular debrisTreatmentEndogenous triggersStimuli-responsive nanoparticle systemToxicitySuccessful deliveryDrug-loaded nanoparticlesUltrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform
Bhardwaj P, Goda JS, Pai V, Chaudhari P, Mohanty B, Pai T, Vishwakarma K, Thorat R, Wadasadawala T, Banerjee R. Ultrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform. Nanoscale 2021, 13: 17077-17092. PMID: 34622906, DOI: 10.1039/d1nr04211d.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerBreast cancerAdvanced triple-negative breast cancerPathological response rateCombination of paclitaxelTumor microvessel densityNOD-SCID micePET-CT imagingDose-dependent systemic toxicityCell proliferation markersChemoradiotherapeutic efficacyClinical radiosensitizerNeoadjuvant chemotherapyNeoadjuvant chemoradiotherapyTNBC xenograftsAggressive tumorsCombinatorial regimenConcomitant useMouse survivalMicrovessel densityPathological responseClinical utilitySpatio-temporal deliveryResponse rateSolid tumorsImmunomodulatory nanosystems for treating inflammatory diseases
Ahamad N, Kar A, Mehta S, Dewani M, Ravichandran V, Bhardwaj P, Sharma S, Banerjee R. Immunomodulatory nanosystems for treating inflammatory diseases. Biomaterials 2021, 274: 120875. PMID: 34010755, DOI: 10.1016/j.biomaterials.2021.120875.Peer-Reviewed Original ResearchConceptsHyperactive immune cellsInflammatory diseasesImmune cellsInflammatory bowel diseaseShort-term reliefMechanism of actionCytokine neutralizationStandard therapyT-regsBowel diseaseImmunosuppressive agentsChronic inflammationCytokine productionImmunomodulatory actionsMyocardial infarctionPulmonary disordersMacrophage polarizationInflamed sitesTherapeutic advantageCellular infiltrationLymphatic drainageImmune systemCentral manifestationsSevere burdenDisease
2020
Clinical Toxicity of Nanomedicines
Ahamad N, Bhardwaj P, Bhatia E, Banerjee R. Clinical Toxicity of Nanomedicines. 2020, 533-560. DOI: 10.1007/978-981-15-6255-6_20.ChaptersMultifunctional Core–Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy
Balakrishnan B, Subramanian S, Mallia MB, Repaka K, Kaur S, Chandan R, Bhardwaj P, Dash A, Banerjee R. Multifunctional Core–Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy. Biomacromolecules 2020, 21: 2645-2660. PMID: 32484667, DOI: 10.1021/acs.biomac.0c00358.Peer-Reviewed Original ResearchConceptsCore-shell nanoparticlesTarget specific drug releaseMultivalent ligand presentationCombination drug deliveryBoronate estersDrug releaseSchiff baseMDA-MB-231 cancer cellsCitrus pectinDrug deliveryNanoparticlesPlacebo nanoparticlesProof of conceptPeriodate oxidationLigand presentationGlyconanoparticlesVivo monitoringEnhanced internalizationTarget specificityGastric tractTriple-negative MDA-MB-231 breast cancer cellsBiodistribution studiesHomotypic cellular aggregationDoxorubicinShellAdvancements in prophylactic and therapeutic nanovaccines
Bhardwaj P, Bhatia E, Sharma S, Ahamad N, Banerjee R. Advancements in prophylactic and therapeutic nanovaccines. Acta Biomaterialia 2020, 108: 1-21. PMID: 32268235, PMCID: PMC7163188, DOI: 10.1016/j.actbio.2020.03.020.Peer-Reviewed Original ResearchConceptsImmune responseConventional vaccinesSuitable immune responsePathological conditionsAntibody-mediated immunityImmune system activationStrong immune responseNon-infectious diseasesHigh antigen loadingBooster dosesLymph nodesImmunodeficiency syndromeImmune activationTreatment of cancerMultiple dosesEnhanced immunogenicityAntigen presentationForeign antigensAntigen loadingPatient complianceNovel nanovaccinesSystem activationImmune systemVaccine developmentTherapeutic potential