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A systematic review and meta-analysis of 26 randomized clinical trials with 1,166 patients with a major depressive episode found that ketamine was efficacious in reducing suicidal and depressive symptoms rapidly, within hours. Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of the paper, published in JAMA Psychiatry.

Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of a paper in JAMA Psychiatry that evaluates how FDA–approved atypical antipsychotics in major depressive disorder compare with respect to overall efficacy and acceptability.

Sophie Holmes, PhD, assistant professor of psychiatry, is first author of a paper in Neuropsychopharmacology that explores the use of molecular imaging to guide the development of treatments that could reduce the burden of late-life depression.

Ben Coleman, MD, PhD, and Ann Johnson, PhD, will join the Albert J. Solnit Integrated Child, Adolescent, and Adult Psychiatry Program at Yale Child Study Center as new residents this summer. Coleman and Johnson were announced as part of the Department of Psychiatry’s 2026 Match Class, after the annual match process concluded in March.

“During the winter months, we’re robbed of exposure to sunlight. In order to have vitamin D metabolized, you need sunlight. So people have low vitamin D levels, which is linked to depression,” said Robert Ostroff, MD, co-medical director of Interventional Psychiatry Service at Yale New Haven Psychiatric Hospital and clinical professor of Psychiatry at Yale School of Medicine.

Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of a paper in JAMA that found adolescents are suffering from insufficient sleep and that the problem is particularly pronounced among those with depressive symptoms or suicidal thoughts.

One week into the new year, thousands of people across the country are participating in “Dry January,” a challenge to cut out alcohol for the entire month. “It’s a way of resetting after holiday spirits get a little bit out of hand and people tend to overdrink and overeat,” said Robert Ostroff, MD, co-medical director of interventional psychiatry at Yale New Haven Psychiatric Hospital.

Greg Rhee, PhD, associate professor adjunct in psychiatry, is first author of a paper in BMJ Mental Health that reviews the effects of electroconvulsive therapy on all-cause mortality and suicide deaths in severe unipolar or bipolar depression using longitudinal studies.

Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of a paper in eClinical Medicine that compares the effectiveness of repetitive transcranial magnetic stimulation, intranasal esketamine, and pharmacotherapy for treatment-resistant depression using data from two clinical trials.