Publications

2026

BPS2026 – Molecular simulations of proton-coupled neurotransmitter transport by VMAT2
Suomivuori C. BPS2026 – Molecular simulations of proton-coupled neurotransmitter transport by VMAT2. Biophysical Journal 2026, 125: 239a. DOI: 10.1016/j.bpj.2025.11.1566.
Peer-Reviewed Original Research

2025

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics
Jain M, Gumpper R, Slocum S, Schmitz G, Madsen J, Tummino T, Suomivuori C, Huang X, Shub L, DiBerto J, Kim K, DeLeon C, Krumm B, Fay J, Keiser M, Hauser A, Dror R, Shoichet B, Gloriam D, Nichols D, Roth B. The polypharmacology of psychedelics reveals multiple targets for potential therapeutics. Neuron 2025, 113: 3129-3142.e9. PMID: 40683247, DOI: 10.1016/j.neuron.2025.06.012.
Peer-Reviewed Original Research
Concepts
Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2
Kugawa M, Kawakami K, Kise R, Suomivuori C, Tsujimura M, Kobayashi K, Kojima A, Inoue W, Fukuda M, Matsui T, Fukunaga A, Koyanagi J, Kim S, Ikeda H, Yamashita K, Saito K, Ishikita H, Dror R, Inoue A, Kato H. Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2. Nature Communications 2025, 16: 2809. PMID: 40140663, PMCID: PMC11947310, DOI: 10.1038/s41467-025-57983-4.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Structure of mitochondrial pyruvate carrier and its inhibition mechanism
He Z, Zhang J, Xu Y, Fine E, Suomivuori C, Dror R, Feng L. Structure of mitochondrial pyruvate carrier and its inhibition mechanism. Nature 2025, 641: 250-257. PMID: 40044865, PMCID: PMC12043432, DOI: 10.1038/s41586-025-08667-y.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
BPS2025 - Targeting hidden receptor conformations to design subtype-selective drugs
Suomivuori C, Dror R. BPS2025 - Targeting hidden receptor conformations to design subtype-selective drugs. Biophysical Journal 2025, 124: 230a. DOI: 10.1016/j.bpj.2024.11.1261.
Peer-Reviewed Original Research

2024

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
Hoppe N, Harrison S, Hwang S, Chen Z, Karelina M, Deshpande I, Suomivuori C, Palicharla V, Berry S, Tschaikner P, Regele D, Covey D, Stefan E, Marks D, Reiter J, Dror R, Evers A, Mukhopadhyay S, Manglik A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature Structural & Molecular Biology 2024, 31: 667-677. PMID: 38326651, PMCID: PMC11221913, DOI: 10.1038/s41594-024-01223-8.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Molecular simulation for safer psychedelic therapies
Suomivuori C, Dror R. Molecular simulation for safer psychedelic therapies. Biophysical Journal 2024, 123: 171a. DOI: 10.1016/j.bpj.2023.11.1132.
Peer-Reviewed Original Research

2023

2022

2021

Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Harris J, Faust B, Gondin A, Dämgen M, Suomivuori C, Veldhuis N, Cheng Y, Dror R, Thal D, Manglik A. Selective G protein signaling driven by substance P–neurokinin receptor dynamics. Nature Chemical Biology 2021, 18: 109-115. PMID: 34711980, PMCID: PMC8712391, DOI: 10.1038/s41589-021-00890-8.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2020

2019

2017

Energetics and dynamics of a light-driven sodium-pumping rhodopsin
Suomivuori C, Gamiz-Hernandez A, Sundholm D, Kaila V. Energetics and dynamics of a light-driven sodium-pumping rhodopsin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 7043-7048. PMID: 28611220, PMCID: PMC5502629, DOI: 10.1073/pnas.1703625114.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2016

See All Publications

Publications

2026

BPS2026 – Molecular simulations of proton-coupled neurotransmitter transport by VMAT2

2025

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics

Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2

Structure of mitochondrial pyruvate carrier and its inhibition mechanism

BPS2025 - Targeting hidden receptor conformations to design subtype-selective drugs

2024

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

Molecular simulation for safer psychedelic therapies

2023

A positively tuned voltage indicator for extended electrical recordings in the brain

How ligands achieve biased signaling at opioid receptors

Structural basis for activation of CB1 by an endocannabinoid analog

2022

Insights into distinct signaling profiles of the µOR activated by diverse agonists

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

Autoantibody mimicry of hormone action at the thyrotropin receptor

Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia

Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins

2021

Selective G protein signaling driven by substance P–neurokinin receptor dynamics

2020

How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling

Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

Molecular Mechanism of Biased Signaling in a Prototypical G-protein-coupled Receptor

2019

Conformational transitions of a neurotensin receptor 1–Gi1 complex

Absorption shifts of diastereotopically ligated chlorophyll dimers of photosystem I

2017

Energetics and dynamics of a light-driven sodium-pumping rhodopsin

2016

Exploring the Light-Capturing Properties of Photosynthetic Chlorophyll Clusters Using Large-Scale Correlated Calculations

Tuning the Protein‐Induced Absorption Shifts of Retinal in Engineered Rhodopsin Mimics