CPIRT Center Media

David Stitelman, MD, has received funding from the Cystic Fibrosis Research Institute to advance his collaborative research on a novel fetal therapy approach for cystic fibrosis. Working with colleagues across pediatric pulmonology, biomedical engineering, and gene editing, his team is developing nanoparticle-based strategies to deliver gene therapies before birth—aimed at preventing organ damage that begins in utero. By combining mRNA delivery and high-fidelity gene editing, this work has the potential to move toward a one-time treatment for cystic fibrosis and establish a new paradigm for treating genetic diseases before birth.

People diagnosed with chronic obstructive pulmonary disease often experience markedly different symptoms, disease trajectories, and responses to treatment. To better understand this variability, a new study from researchers at Yale School of Medicine used single-cell sequencing technology alongside complementary spatial transcriptomic and proteomic analyses to examine lung tissue from people with COPD in unprecedented detail.

A new study from Yale researchers identifies an epithelial-immune signaling pathway crucial to the lung’s injury-repair process. When this signaling is altered, the study shows, it may help push the lung toward fibrosis.

A new Yale-led study sheds light on how asthma behaves differently in males and females, both in symptoms and at the level of gene expression.

The Yale Pepper Older Americans Independence Center (OAIC) is soliciting letters of intent from full-time Yale faculty members with interests and expertise relevant to aging research for the Research Education Core (REC) and Pilot Exploratory Study Core (PESC) awards.

A new collaborative program, the Ugandan Registry of RMDs in HIV (GEMINI), aims to improve the study of HIV and rheumatic and musculoskeletal diseases (RMDs) in Uganda.

In a new study, Yale researchers develop a method that has the potential to cure cystic fibrosis prior to birth. 

Two new YSPH research studies look at health care practices in China and the impact of pollution and high temperatures on children's mental health.

Congratulations to the Yale Department of Internal Medicine faculty members who were recently promoted, appointed, or reappointed.