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INFORMATION FOR

    Lester Rodriguez Santos, BSc (Hon)

    he/him/his
    PhD Candidate , Interdepartmental Neuroscience Program
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    About

    Titles

    PhD Candidate , Interdepartmental Neuroscience Program

    Biography

    Lester earned a B.S. in Cellular and Molecular Biology from the University of Puerto Rico, Río Piedras Campus in San Juan, Puerto Rico. As an undergraduate, he conducted research using pre-clinical rodent models to investigate the role of endocannabinoids in regulating anxiety-like behaviors.

    Following graduation, he joined the Neuroimaging Research Branch at the National Institute on Drug Abuse as a postbaccalaureate fellow under the mentorship of Dr. Elliot Stein. His work focused on examining alterations in functional connectivity during acute nicotine abstinence in smokers.

    At Yale, Lester is co-mentored by Dr. Sarah W Yip and Dr. Kelly Cosgrove. His research focuses on examining how acute stimulant drug administration affects brain function and behavior, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET).

    In addition to his research, Lester is committed to scientific outreach and education. He currently serves as Director of OpenLabs at Yale, a student-led initiative that hosts science outreach events on campus each semester. He also serves as Outreach Co-Chair for the Wu Tsai Institute’s Student, Postbac, and Postdoc Collective (SPPC), where he developed an annual Neuroscience and Cognition Bootcamp for local high school students. These efforts led to his receiving the 2025 Public Service Award from the Graduate School of Arts and Sciences for Disciplinary Outreach.

    Last Updated on April 25, 2026.

    Education & Training

    BSc (Hon)
    University of Puerto Rio - Rio Piedras Campus, Cellular and Molecular Biology (2020)

    Research

    Overview

    1. Explore the effects of acute stimulant drug administration on functional connectivity in healthy adults with resting-state fMRI.
    2. Link stimulant-induced alterations of functional connectivity to dopamine release through PET imaging.
    3. Identify biomarkers of stimulant misuse vulnerability.

    Medical Research Interests

    Affect; Amphetamine; Central Nervous System Stimulants; Connectome; Dopamine; Euphoria; Magnetic Resonance Imaging; Receptors, Dopamine

    Public Health Interests

    Substance Use, Addiction

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Lester Rodriguez Santos's published research.

    Academic Achievements & Community Involvement

    Activities

    • activity

      Open Labs at Yale

    Honors

    • honor

      Graduate Research Fellowship Program (GRFP)

    • honor

      Graduate Fellow

    Get In Touch

    Contacts

    Locations

    • Cosgrove Lab - Yale Translational Brain Imaging Program

      Lab

      Temple Medical Center

      40 Temple Street

      New Haven, CT 06510

    • Yale Imaging & Psychopharmacology (YIP) Lab

      Lab

      1 Church Street

      New Haven, CT 06510