Elise Liu, MD, PhD
Instructor of MedicineCards
About
Research
Publications
2025
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
Siniscalco E, Meng H, Gabernet G, Pacheco G, Saghaei S, Ramirez S, Hills L, Faraji F, Chen S, Yin X, Dien C, Hoyt L, Liu E, Barrett A, Briggs N, Williams A, Shukla V, Crotty S, Wesemann D, Kleinstein S, Craft J, Eisenbarth S. Sequential class switching generates antigen-specific gut IgA from IgG1 B cells. Immunity 2025, 58: 3075-3093.e6. PMID: 41253159, PMCID: PMC12834128, DOI: 10.1016/j.immuni.2025.10.022.Peer-Reviewed Original ResearchThis study investigates how gut-specific IgA antibodies are generated from IgG1 B cells through sequential class switching, highlighting a crucial mechanism for designing effective mucosal vaccines.Dendritic Cells: at the Crossroads between Oral Tolerance and Food Allergy
Butler K, Liu E. Dendritic Cells: at the Crossroads between Oral Tolerance and Food Allergy. Current Allergy And Asthma Reports 2025, 25: 50. PMID: 41148450, DOI: 10.1007/s11882-025-01230-9.Peer-Reviewed Original ResearchConceptsAntigen presenting cellsDendritic cellsFood toleranceOral tolerancePresenting cellsAllergic sensitizationSpecialized antigen presenting cellsDendritic cell subsetsDendritic cell responsesFood allergy preventionFood allergy pathogenesisFood allergy treatmentAdaptive immune responsesOral immunotherapySublingual immunotherapyCell subsetsBridge innateAllergy pathogenesisTreatment strategiesAllergy preventionAllergy treatmentFood allergyImmune responseCell responsesImmunotherapyThe power of the few: RORγt+ dendritic cells promote food-specific peripheral regulatory T cells.
Liu E, Williams A. The power of the few: RORγt+ dendritic cells promote food-specific peripheral regulatory T cells. Science Immunology 2025, 10: eaec5741. PMID: 41042910, DOI: 10.1126/sciimmunol.aec5741.Peer-Reviewed Original ResearchCysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
Hoyt L, Liu E, Olson E, Jacobsen D, Siniscalco E, Krier-Burris R, Greenfield K, McBride C, Alfajaro M, Amat J, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger D, Zhang L, Bunyavanich S, Glass S, Coffey R, Wilen C, Williams A, Eisenbarth S. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. Science 2025, 389: eadp0240. PMID: 40773557, PMCID: PMC12333546, DOI: 10.1126/science.adp0240.Peer-Reviewed Original ResearchConceptsFood-specific immunoglobulin ESensitivity to anaphylaxisFood-specific IgEResistant C57BL/6 miceFood allergensLife-threatening anaphylaxisStrains of miceGut absorptionOral anaphylaxisSusceptible miceResistant miceC57BL/6 miceCysteinyl leukotrienesAllergen consumptionAllergic sensitizationFood allergyImmunoglobulin EAllergen absorptionAnaphylaxisIntestinal epitheliumMiceIntestinal goblet cellsAllergen transportSynthesis inhibitorGoblet cells
2024
Dendritic cells in food allergy, treatment, and tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic cells in food allergy, treatment, and tolerance. The Journal Of Allergy And Clinical Immunology 2024, 154: 511-522. PMID: 38971539, PMCID: PMC11414995, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune responseFood Matrix Composition Affects the Allergenicity of Baked Egg Products
Liu, E.G., Tan, J., Munoz, J.S., Shabanova, V., Eisenbarth, S.C., Leeds, S. Food matrix composition affects the allergenicity of baked egg products. J Allergy Clin Immunol Pract, 2024.Peer-Reviewed Original Research In PressFood Matrix Composition Affects the Allergenicity of Baked Egg Products
Liu E, Tan J, Munoz J, Shabanova V, Eisenbarth S, Leeds S. Food Matrix Composition Affects the Allergenicity of Baked Egg Products. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 2111-2117. PMID: 38670261, PMCID: PMC11580806, DOI: 10.1016/j.jaip.2024.04.032.Peer-Reviewed Original ResearchEgg allergensEgg productionFood matricesExtract ovalbuminFood matrix compositionAllergenicity of eggBaked eggMuffin recipeQuantify ovalbuminRice muffinsRice flourWheat flourBlocking ELISAWheat muffinsFood ingredientsMuffinsHeated eggEgg proteinsEgg-allergic patientsWheatEggsFood allergic reactionsReduced allergenicityFlourFoodNovel and emerging tests for food allergy
Liu E, Eisenbarth S. Novel and emerging tests for food allergy. 2024, 698-709. DOI: 10.1016/b978-0-323-96018-2.00081-x.Peer-Reviewed Original ResearchFood allergyActivation testingSkin prick testingRisk of developmentAvailable clinical testsSkin barrier permeabilityLow predictive valueInflammatory markersPrick testingIgE testingImmunoglobulin EBarrier permeabilityAllergyPromising biomarkerPredictive valueClinical testsGenetic testingLack of testingCellular profilingMarkersWidespread useTestingImmunoglobulinBiomarkersSeverity
2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, PMCID: PMC11571232, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activation
2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens
Liu E, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro J, Chinthrajah S, Sindher T, Manohar M, Quake A, Nadeau K, Burks A, Kim E, Kulis M, Henning A, Jones S, Leung D, Sicherer S, Wood R, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth S. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Science Translational Medicine 2022, 14: eabq0599. PMID: 36383680, PMCID: PMC10219469, DOI: 10.1126/scitranslmed.abq0599.Peer-Reviewed Original ResearchConceptsPeanut allergyFood allergyEpitope specificityPredominant antibody isotypePeanut-specific IgEDifferent epitope specificitiesSimilar epitope specificityAtopic childrenEgg allergyOral toleranceAllergic infantsImmune exclusionEgg toleranceAntibody isotypesImmunoglobulin ACommensal floraSeparate cohortAllergyEgg allergensInfant stoolHealthy adultsIgAProtective roleOlder childrenChildren
Academic Achievements & Community Involvement
Clinical Care
Overview
Elise Liu, MD, PhD, is an allergist and immunologist who helps people manage a variety of immune system conditions, including food allergies. She focuses on diagnosing allergic reactions and offering testing and personalized treatment strategies.
As an instructor of medicine at Yale School of Medicine, Dr. Liu conducts research on food allergies, focusing on the production and role of gut immunoglobulin A, an antibody essential for the immune response in the intestines. Her work aims to deepen the understanding of how food allergies begin and progress, with a goal to develop effective treatments.
Dr. Liu completed her medical training, a residency in internal medicine, and a fellowship in allergy and immunology at Yale School of Medicine.
Clinical Specialties
Allergy & Clinical Immunology
Fact Sheets
Alpha-gal Syndrome (AGS)
Learn More on Yale Medicine
Board Certifications
Allergy & Immunology
- Certification Organization
- AB of Allergy & Immunology
- Original Certification Date
- 2021
News
News
- September 03, 2025Source: Prevention
12 Signs That Your Digestive Problems Could Be an Undiagnosed Food Allergy, According to Experts
- December 04, 2024
Three Common Food Allergy Myths Debunked
- April 22, 2024
Beyond Weight Loss: Five Yale Experts on the Benefits of Exercise
- March 19, 2024Source: Prevention
10 Food Allergy Symptoms in Adults, and How to Treat and Prevent a Reaction
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Yale School of Medicine
1 Gilbert St.
New Haven, CT 06519
United States
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