Vincent Graziano
Postdoctoral AssociateAbout
Research
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RNA N-glycosylation enables immune evasion and homeostatic efferocytosis
Graziano V, Porat J, Ah Kioon M, Mejdrová I, Matz A, Lebedenko C, Chai P, Pluvinage J, Ricci-Azevedo R, Harrison A, Wright S, Wang X, Strine M, Wang P, Wilson M, Vanaja S, Zhou B, Barrat F, Carell T, Flynn R, Rathinam V. RNA N-glycosylation enables immune evasion and homeostatic efferocytosis. Nature 2025, 645: 784-792. PMID: 40770106, PMCID: PMC12845878, DOI: 10.1038/s41586-025-09310-6.Peer-Reviewed Original ResearchConceptsNon-inflammatory clearanceN-glycansSmall RNAsInnate immune sensingApoptotic cellsEndogenous small RNAsFunctional significanceProduction of type I interferonsDe-N-glycosylationInnate immune activationEndosomal networkInnate immune responseClearance of dead cellsN-glycosylationRNA sensorsType I interferonToll-like receptorsRNAGlycoRNACell surfaceGenetic deletionI interferonDead cellsAcp3UAutoinflammatory responses