Judy Chen, MS, PA, PA-C
Surgical Oncology APP- YNHHCards
About
Research
Publications
2024
iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection
Hill B, Zak A, Raja S, Bugada L, Rizvi S, Roslan S, Nguyen H, Chen J, Jiang H, Ono A, Goldstein D, Wen F. iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection. JCI Insight 2024, 9: e172140. PMID: 38814732, PMCID: PMC11383363, DOI: 10.1172/jci.insight.172140.Peer-Reviewed Original ResearchInfluenza infectionImmune cell typesCourse of influenza infectionDefective T cell responsesSurvival of C57BL/6 miceCell typesDecreased IL-10 expressionEffect of host genetic backgroundT cell responsesGenetic backgroundTime-of-flight (CyTOFIL-10 expressionInflammatory cell typesCells in silicoHost genetic backgroundC57BL/6 miceAged miceMouse lungHost genotypeInfection susceptibilityHost factorsEffects of ageMiceHealth burdenInfectionPublisher Correction: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Tyrrell D, Wragg K, Chen J, Wang H, Song J, Blin M, Bolding C, Vardaman D, Giles K, Tidwell H, Ali M, Janappareddi A, Wood S, Goldstein D. Publisher Correction: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nature Aging 2024, 4: 1166-1166. PMID: 38789547, DOI: 10.1038/s43587-024-00653-9.Peer-Reviewed Original ResearchBiomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts
Urie R, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li J, Goldstein D, Shea L. Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts. Science Advances 2024, 10: eadk6178. PMID: 38748794, PMCID: PMC11095459, DOI: 10.1126/sciadv.adk6178.Peer-Reviewed Original ResearchConceptsGraft biopsyGraft injuryRag2-/- miceAdoptive transfer of T cellsTransfer of T cellsRejection of organ allograftsAcute cellular allograft rejectionCellular allograft rejectionEfficacy of immunosuppressionPredominant innate immune cellsInnate immune cellsRisk of rejectionWild-type animalsPersonalized immunosuppressionAdoptive transferAcute rejectionOrgan allograftsAllograft rejectionFrequent biopsiesT cellsImmune cellsTransplant rejectionImmunological nicheRespiratory infectionsInflammatory insult
2023
Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Tyrrell D, Wragg K, Chen J, Wang H, Song J, Blin M, Bolding C, Vardaman D, Giles K, Tidwell H, Ali M, Janappareddi A, Wood S, Goldstein D. Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nature Aging 2023, 3: 1576-1590. PMID: 37996758, PMCID: PMC11924142, DOI: 10.1038/s43587-023-00515-w.Peer-Reviewed Original ResearchConceptsT cellsMemory CD8Aged miceAtherosclerotic plaquesDepletion of CD8Effector memory subsetsStrong risk factorT cell activationEnhanced atherosclerosisSplenic CD8Adoptive transferDonor miceMemory subsetsRecipient miceRisk factorsCD8Therapeutic targetCell activationAtherosclerosisSingle-cell RNA sequencingMiceTranscriptomic signaturesAtherogenesisPlaquesRNA sequencingTissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection
Urie R, Xiao C, Hughes E, Lombard E, Chen J, Morris A, Farris D, Goldstein D, Shea L. Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection. The Journal Of Immunology 2023, 210: 173.40-173.40. DOI: 10.4049/jimmunol.210.supp.173.40.Peer-Reviewed Original ResearchAcute cellular allograft rejectionEndomyocardial biopsyRisk of rejectionAllograft rejectionT cell-mediated rejectionRoutine endomyocardial biopsyCellular allograft rejectionHeterotopic heart transplantationMinimally-invasive samplingHealthy allograftsPersonalized immunosuppressionGraft biopsyPredictive biomarkersImmune suppressionHeart transplantationImmune cellsInvasive biopsyImmunological nicheHistological evidenceSkin transplantationBiopsyHistological evaluationGene profilesMolecular biomarkersPorous biomaterials
2022
OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment
Hong H, Mbah N, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa L, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein D, Carty S, Lei Y, Opipari A, Argüello R, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis C. OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment. Science Immunology 2022, 7: eabm8182. PMID: 36399539, PMCID: PMC9853437, DOI: 10.1126/sciimmunol.abm8182.Peer-Reviewed Original ResearchConceptsOxidative phosphorylationBcl-xLApoptotic resistanceIncreased mitochondrial fitnessTargeting oxidative phosphorylationMediators of host defenseMitochondrial oxidative phosphorylationTumor microenvironmentOxidative phosphorylation conditionsAdoptive T cell therapyFunction in vivoImmune responseMurine model of melanomaEffector function in vivoGlutamine anaplerosisOPA-1T-cell therapyCell fateCD4 T cellsImpaired effector functionsAdoptive transfer experimentsMitochondrial fitnessCellular persistenceModel of melanomaT cell proliferation
Clinical Care
Overview
Judy Chen is a skilled surgical oncology physician associate who specializes in caring for patients with cancers affecting the gastrointestinal system, pancreas, liver, and breast. She assists during surgeries, helps optimize patient recovery post-surgery, and manages the medical needs of patients before, during, and after surgery.
“Is an honor and a privilege to work with cancer patients, because I can be there for them during one of the most vulnerable times of their lives,” says Chen, who earned her graduate degree from Northeastern University and completed residencies at Norwalk Hospital and Yale New Haven Hospital.
Clinical Specialties
Surgical Oncology
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