YALE BIOMEDICAL IMAGING INSTITUTE OVERVIEW

Transcript

• 00:00Thank you. So we have
• 00:02a very busy schedule as
• 00:03you can see.
• 00:05We're gonna have we're gonna
• 00:06try to stick to time,
• 00:08and have a quick overview
• 00:09of the institute and then,
• 00:11two selected features of what
• 00:12kind of imaging
• 00:13you may be, interested in.
• 00:16We'll have also a session
• 00:17on translation where, actually,
• 00:19non radiologists who are
• 00:22every bit as good at
• 00:22imaging as radiologists will be
• 00:24presenting on what they do
• 00:25in their areas,
• 00:26and then, we'll have the
• 00:28data science at the end.
• 00:29After that, as Dean Brown
• 00:30mentioned, there will be a
• 00:31break. We'll have after that
• 00:32a round table with chairs
• 00:34and then, the posters, forty
• 00:36two posters. So please,
• 00:38please go and look at
• 00:39them.
• 00:40Alright. So
• 00:42I'm gonna start with our
• 00:44vision.
• 00:47When we started looking at
• 00:48this, the idea was to
• 00:49leverage existing strength at Yale
• 00:51because there are
• 00:53incredibly strong groups in very,
• 00:57different areas who have done
• 00:58very seminal work. And the
• 01:00idea was to bring together
• 01:01more of these,
• 01:03groups into
• 01:04multimodality,
• 01:05multi organ kind of,
• 01:07work.
• 01:08And our mission was, at
• 01:09least the way we stated
• 01:11it initially, was to cultivate
• 01:12an interdisciplinary
• 01:13dynamic research environment.
• 01:15And we want to transform
• 01:16our understanding of health and
• 01:18disease, both through imaging.
• 01:19My partners in crime, and
• 01:21you'll see how we all
• 01:22came to be the band,
• 01:23are doctor Chi Lu, who's
• 01:24here, doctor Dustin Shanos, doctor
• 01:26Kelly Cosgrove,
• 01:27doctor Simran Papi and Dimitris,
• 01:29and then doctor Kira Gragg,
• 01:30who's our communication director.
• 01:32We are two hundred and
• 01:33fifty.
• 01:34Nothing like a pilot study
• 01:36to bring a lot of
• 01:36membership.
• 01:38Many different areas, as you
• 01:39can see. Obviously, the big
• 01:41majority is faculty, but we
• 01:43have also,
• 01:44chemist, secretary of engineers, associate
• 01:46members, regulatory,
• 01:47architects,
• 01:49many different
• 01:50folks.
• 01:51And, we are from thirty
• 01:53three departments.
• 01:54So,
• 01:55while radiology is the biggest
• 01:57contributor,
• 01:58it is probably also gonna
• 02:00be at that level because
• 02:01we have almost everybody from
• 02:03radiology in there. It's everybody
• 02:04in other departments that are
• 02:05growing, and that's where we're
• 02:06seeing a lot of those
• 02:07trends.
• 02:08And we hope that if
• 02:09you're not a member, you
• 02:10may consider being a member.
• 02:12So where we started? Actually,
• 02:14before the first data I
• 02:15want to show,
• 02:16something that happened before my
• 02:18time,
• 02:19was
• 02:20strategic
• 02:21studies that were done at
• 02:22Yale to look at what
• 02:23areas should be concentrated on,
• 02:25and one was imaging and
• 02:26one was
• 02:28data sciences and AI.
• 02:30And so,
• 02:32as I, as I joined
• 02:34Yale, we had about a
• 02:35year, eleven months of a
• 02:37listening
• 02:38tour, over forty
• 02:39meetings,
• 02:40where a lot of ideas
• 02:41emerged. And one of them
• 02:42that crystalized very quickly was
• 02:45the need for an institute
• 02:46that would
• 02:48be prepared to be presented
• 02:49for the corporation.
• 02:51It was also the very
• 02:52first micro capacity that was
• 02:53awarded,
• 02:54that is now sitting in
• 02:56the institute.
• 02:57By October twenty four, the
• 02:59proposal
• 03:00was submitted to the corporation,
• 03:02and
• 03:04a previously funded transplantation grant
• 03:06for small animals was installed.
• 03:08The corporation voted on the
• 03:09institute on December twenty second,
• 03:11perfect Christmas gift. And then,
• 03:13we prepared for launch in
• 03:15January to March this year.
• 03:17We solicited applications for associate
• 03:19directors.
• 03:21We interviewed the associate directors.
• 03:22Those were announced.
• 03:24And then, just in time
• 03:25for the first predoctoral training
• 03:27grant to be awarded
• 03:28and for the phase two
• 03:30planning for our renovations that
• 03:31I'll show you.
• 03:33This July, August, we're lucky
• 03:35to,
• 03:36hear from NIH about another,
• 03:38shared instrumentation grant for Panama.
• 03:40We did announce our first
• 03:42pilot studies, and the reviews
• 03:44of those are due Friday.
• 03:46If you're one of the
• 03:46reviewers,
• 03:48please
• 03:49sorry. Thursday.
• 03:51This is probably
• 03:53you can tell I'm thinking
• 03:54like a reviewer. This is
• 03:55probably the only grant you'll
• 03:57ever have where you have
• 03:58three experts who know what
• 03:59you're doing. Like, we picked
• 04:01three experts. I've been chair
• 04:02of many study sections you
• 04:03don't get that often,
• 04:05at NIH.
• 04:06And then,
• 04:08there will be,
• 04:09there will be a synergy
• 04:11forum with cardiology and one
• 04:13with oncology in the coming
• 04:15year.
• 04:16So looking forward, where are
• 04:18we going?
• 04:19Well,
• 04:20as we had our first
• 04:21all member meeting in, this
• 04:23year in August or in
• 04:24September, we just learned that,
• 04:26you know, our large renovation
• 04:29grant, c o six, was
• 04:30funded for renovating some of
• 04:31what I'll show you. So
• 04:33this is gonna start now,
• 04:35and, we're doing this dean
• 04:37workshop today.
• 04:38We're hoping by November to
• 04:39February this year, there will
• 04:41be another synergy forum with,
• 04:42the cancer center,
• 04:44and we're organizing an event
• 04:45for graduate students to connect
• 04:46with faculty.
• 04:48Looking forward, we're excited for
• 04:49ongoing collaborations and new partnerships.
• 04:51As Deneen mentioned, if there's
• 04:53one thing you should take
• 04:53from today, it's give you
• 04:54an idea of who you
• 04:55could be working with and
• 04:56what could you be working
• 04:57on. That's one thing to
• 04:59take home.
• 05:00Alright. Major initiatives.
• 05:03Innovation,
• 05:04think big science.
• 05:06We want to look
• 05:07at high impact, high reward
• 05:09exploratory studies.
• 05:10We are building a data
• 05:12repository with a lot of
• 05:13our research studies. There are
• 05:14over twenty thousand studies done
• 05:16in the Pet Research Center
• 05:17and five times that in
• 05:18the MR Research Center.
• 05:20And we would like to
• 05:21make that available for folks
• 05:23so that when somebody's planning
• 05:25to budget for a study,
• 05:26they don't need to budget
• 05:27for the twenty normal controls
• 05:29and the twenty afflicted group.
• 05:31They could use some of
• 05:32that.
• 05:33Collaboration, collaboration, collaboration. We want
• 05:35the sum to be more
• 05:36than the parts.
• 05:37All these joint workshops, talks,
• 05:39conferences,
• 05:40it's for one aim and
• 05:41one aim only collaboration.
• 05:43Training, as I mentioned,
• 05:44there's already been some early
• 05:46successes in predoctoral and
• 05:48probably more to come in
• 05:49postdoctoral. There will be an
• 05:51F31 workshop
• 05:52for predoctoral.
• 05:54And most importantly, imaging course,
• 05:55this is the,
• 05:57really the,
• 05:59bay this is the support
• 06:01for everything we do.
• 06:02You'll hear about two of
• 06:04those today about a lot
• 06:05of the imaging there, but
• 06:06this is where
• 06:07a lot of the technology
• 06:08is done.
• 06:10These are the three
• 06:12different thematic centers that,
• 06:15my colleagues lead.
• 06:17One is in technology,
• 06:19one is in translation, and
• 06:20one is data science.
• 06:22I'm not gonna go in
• 06:23details on what is in
• 06:24each of them, and I'm
• 06:25not gonna go over all
• 06:25of this.
• 06:27You will hear about this
• 06:28today. I just wanna single
• 06:29out a couple of things
• 06:30that we will probably not
• 06:31talk too much about, but
• 06:32that are very important,
• 06:34including the,
• 06:35instrumentation,
• 06:36development of building of scanners.
• 06:38We were incredibly lucky to
• 06:39be the only site that
• 06:41received
• 06:42a a u o one
• 06:43brain to build the neuro
• 06:44explorer
• 06:45and a u o one
• 06:46brain to build the savant,
• 06:47which got us to the
• 06:48best sensitivity of any brain
• 06:50scanner and,
• 06:51hopefully, some of the best
• 06:52resolution. We're already working on
• 06:54generation two point o.
• 06:56We are one of the
• 06:56very few sites who received,
• 07:00a large ARPA h grant.
• 07:02Sorry. This was
• 07:04Rich Carson for the NeuroExplorer
• 07:06and Mark Newman and myself
• 07:07for the civil.
• 07:09Breast imaging
• 07:11in an accessible
• 07:13mobile MR, something that hasn't
• 07:15been done before,
• 07:16and then looking at a
• 07:18game changer in changing the
• 07:19paradigm of how we image
• 07:20PET with flat panels as
• 07:22opposed to
• 07:23full cylinders cylindrical scanners.
• 07:26The other part that you
• 07:27don't often hear about but
• 07:28I wanna take a minute
• 07:29to discuss,
• 07:31to show you is where
• 07:32the sausages are made. This
• 07:34is where all of the
• 07:35radiochemistry
• 07:35is done. And and this
• 07:37is all these compounds
• 07:39that we all like to
• 07:40use, they're they're there. One
• 07:41of those is a big
• 07:42success story, the SV2A, the
• 07:44synoptic density. You'll see some
• 07:45examples today. We've done over
• 07:46a thousand studies that was
• 07:47developed here at Yale.
• 07:49And then, some other things
• 07:51I wanted to just,
• 07:53a shout out for deuterium
• 07:55imaging. This was developed at
• 07:56Yale, and there's a lot
• 07:58of work happening there in
• 07:59in brain and cardiac.
• 08:01And there's a lot of
• 08:02applications with the SP two
• 08:03a tracer that are all,
• 08:05for the most part, outside
• 08:06of radiology.
• 08:08These are in psychiatry,
• 08:09in neurology, in all sort
• 08:11of, different, departments.
• 08:14One example here of,
• 08:16showing progression in Parkinson
• 08:18disease
• 08:20and depression where you see
• 08:21less and less of the
• 08:22synaptic density, density tracer. And
• 08:24finally, one area that is
• 08:26very promising
• 08:27where we look also for
• 08:28a lot of collaborations between
• 08:30cancer and imaging, and that
• 08:31is in the diagnostic space,
• 08:33where we're looking at looking
• 08:35at what we treat and
• 08:36seeing
• 08:37what we treat and treating
• 08:38what we see, which is
• 08:39something we've never had before.
• 08:40So that would be another
• 08:42area.
• 08:43I mentioned quickly the, core
• 08:45facilities.
• 08:46Just to give you some
• 08:47numbers, there's over a hundred
• 08:49active IRBs,
• 08:50but there's about seven thousand
• 08:51research studies done every year.
• 08:53We have nurses and technologists,
• 08:55and
• 08:56we do our cure line,
• 08:58samplings. We have twenty three
• 09:00nonhuman primates. There are,
• 09:02dedicated brain scanners, dedicated whole
• 09:04body FCT scanners, dedicated MR
• 09:07scanners, five,
• 09:08whole body MR scanners, three
• 09:10three Tesla,
• 09:11one three Tesla Vita and
• 09:13four Tesla Booker. It's like
• 09:14a small hospital, really, and
• 09:16then a whole hospital of
• 09:17small animal scanners.
• 09:19And this research, again, is
• 09:21benefiting everybody. You see the
• 09:23biggest department in terms of
• 09:24studies is psychiatry. And we're
• 09:26hoping that
• 09:28part of what we'll be
• 09:28doing is going below the
• 09:30neck to see more cardiac
• 09:31cancer
• 09:32and other whole body studies
• 09:34as opposed to we'll continue,
• 09:36of course, the brain because
• 09:37that's been the area of
• 09:38excellence that will continue, but
• 09:39we're gonna grow other areas
• 09:40as well.
• 09:42Just to
• 09:44give you a little bit
• 09:45of appetite of what's coming,
• 09:46so
• 09:47these
• 09:48maybe I have oh, hang
• 09:49on.
• 09:56Oh, yeah. So there are
• 09:58two scanners that have been
• 09:59installed for small animal imaging
• 10:01in nonhuman primates, MicroPEC and
• 10:02MicroPEC.
• 10:03Peramar is coming in twenty
• 10:05seven. Savant is coming next
• 10:08year.
• 10:09Seven
• 10:10Tesla, it's coming late in
• 10:11twenty nine, not to give
• 10:12any heart attack to our
• 10:14architects, maybe twenty thirty.
• 10:17Eleven point seven Tesla has
• 10:18been installed
• 10:20a la long axial PET,
• 10:22for twenty eight, and the
• 10:23NeurIPSPORE has been installed in
• 10:25twenty twenty three. And note
• 10:26that most of those have
• 10:27been funded under high end
• 10:28instrumentation grants.
• 10:31In terms of the phases
• 10:32of this, I showed you
• 10:33phase one where a lot
• 10:34of the work has been
• 10:35done. The current phase is
• 10:37installing Speck CT in Panama
• 10:38and the BRAIN Savant. And
• 10:40then the second phase will
• 10:41be the heavy one with
• 10:42the all the other systems.
• 10:45I wanna share with you
• 10:46one,
• 10:47little piece of how we
• 10:49are doing our renovations
• 10:50because it's involving a lot
• 10:51of you.
• 10:53This is the really the
• 10:53first time at least in
• 10:55my from in my experience
• 10:56that I've I've gone through
• 10:58four renovations. Don't ask why,
• 11:00but we've done four renovations
• 11:01of some of these sites.
• 11:03This is the first time
• 11:04where we've gone through this
• 11:05from the point of view
• 11:06also of the patient and
• 11:08the, subject and not just
• 11:10from the investigator and also
• 11:12from the point of view
• 11:12of the technologist and the
• 11:14nurse, meaning
• 11:15what is a day in
• 11:16the life of a subject
• 11:17looks like? What is a
• 11:18day in the life of
• 11:19a research of a nurse
• 11:21look like? And how would
• 11:22it make the most sense
• 11:23to have the best
• 11:26throughput with the least
• 11:27walking distances with the most
• 11:29common spaces when people need
• 11:30them. And I'm very happy
• 11:32with how this is shaping
• 11:33because I think this will
• 11:34be a different model of
• 11:36how we can be efficient
• 11:37and at the same time
• 11:38have a a great workplace.
• 11:40So how can we help
• 11:41you? This is what the
• 11:43discussion is here today about.
• 11:45It's too late for this
• 11:46line of pilot studies if
• 11:48you didn't apply, because reviews
• 11:50are due Thursday.
• 11:52Right now. There will be
• 11:53another round next year. There'll
• 11:55be also a round for
• 11:57lower cost,
• 12:00more like optical or MR
• 12:01imaging in the spring that
• 12:02is announced.
• 12:03There'll be also pre doc
• 12:05and postdoctoral opportunities that will
• 12:06be announced.
• 12:08And more importantly,
• 12:09dissemination.
• 12:10I mentioned the data repository,
• 12:12but we also wanna promote
• 12:13your work on social web
• 12:14pages, email blasts. We wanna
• 12:16be here to showcase you.
• 12:18So if any of this
• 12:19is of interest to you,
• 12:21talk to Kira for this
• 12:22part.
• 12:23Training,
• 12:24workshops, talks, seminars, as I
• 12:26mentioned, and all of that
• 12:27towards collaboration because I really
• 12:28think that big science happen
• 12:30when we all collaborate together.
• 12:33This is it. I would
• 12:34like to thank all those
• 12:35who helped organize this workshop.
• 12:37We would not do this
• 12:38with the without Christina Agro,
• 12:40Kira Grog, Danille Cramp, Savannah
• 12:42Macias, and Li Nurka.
• 12:44Big thank you for Ruth
• 12:46Montgomery. Doctor Montgomery has been
• 12:47on our case to make
• 12:48sure everything was done on
• 12:49time. Thank you. And Beth
• 12:51Pranger.
• 12:52We did everything ahead of
• 12:53time. That doesn't happen often.
• 12:55And then,
• 12:56the communication teams at Yale.
• 12:59So on to the science.
• 13:00We're gonna start with our
• 13:01speakers, one twenty to three
• 13:03fifteen, and then our children's
• 13:04rent table, three fifteen to
• 13:05four fifteen.