Yun Chen
she/her/hers
Postdoctoral AssociateAbout
Research
Publications
2026
Blood Pressure Trajectories in Young Adulthood and Midlife Steatotic Liver Disease.
Chen Y, Zhao L, Zheng Y, Carr J, Gao T, Terry J, Qu Y, Ning H, Zhang X, Wilkins J, Bae S, Carnethon M, Allen N, Jacobs D, Lloyd-Jones D, Hou L, Zhang X. Blood Pressure Trajectories in Young Adulthood and Midlife Steatotic Liver Disease. Hypertension 2026 PMID: 41867060, DOI: 10.1161/hypertensionaha.125.26319.Peer-Reviewed Original ResearchBP trajectoriesYoung adulthoodSystolic BP trajectoriesBlood pressureBlood pressure trajectoriesHigh riskSteatotic liver diseaseHigh blood pressureCARDIA studyElevated-stableHypertensive trajectoryWhite adultsLong-term BP changesPressure trajectoriesModerate-stableAnalytic sampleIdentification of individualsModerate-increasingMid-adulthoodLiver diseaseAbdominal computed tomography scanProspective cohortAccurate identification of individualsDiastolic BP groupPositive associationSex and age differences in the association between obesity and long-term changes with the risk of incident type 2 diabetes mellitus: the Rural Deqing Cohort Study
Wu B, Chen Y, Xu H, Chen Y, Dong X, Fu C. Sex and age differences in the association between obesity and long-term changes with the risk of incident type 2 diabetes mellitus: the Rural Deqing Cohort Study. HepatoBiliary Surgery And Nutrition 2026, 15: 7-7. PMID: 41676777, PMCID: PMC12887344, DOI: 10.21037/hbsn-24-417.Peer-Reviewed Original ResearchRisk of incident T2DMBody mass indexIncident T2DMRisk of T2DMObesity indicesWaist circumferenceRural adultsCohort studyHigher risk of incident T2DMSD incrementType 2 diabetes mellitusAssociation of obesity indicesWaist-to-height ratioIncident type 2 diabetes mellitusElectronic health record systemsRisk of incident type 2 diabetes mellitusLimitations of body mass indexPopulation-based cohort studyAbdominal obesity indicesRural Chinese adultsRisk of type 2 diabetes mellitusConfidence intervalsCases of incident T2DMHealth record systemsWeight changeAssociation of change in healthy lifestyle in early adulthood with steatotic liver disease risk in midlife
Chen Y, Zhao L, Mezzacappa C, Steffen L, Carr J, Gao T, Terry J, Qu Y, Bae S, Taddei T, Justice A, Jacobs D, Lloyd-Jones D, Hou L, Zhang X. Association of change in healthy lifestyle in early adulthood with steatotic liver disease risk in midlife. Clinical Gastroenterology And Hepatology 2026 PMID: 41620192, DOI: 10.1016/j.cgh.2026.01.019.Peer-Reviewed Original ResearchHealthy lifestyle scoreHealthy lifestyleUnhealthy lifestyleLifestyle scoreHealthy behaviorsAbsolute riskBenefits of healthy behavioursRelative riskCoronary Artery Risk DevelopmentMultivariate adjusted relative riskHealthy lifestyle changesAdjusted relative risksEarly adulthoodYoung adultsLiver disease riskSteatotic liver diseasePhysical activityGenetic predispositionNon-contrast abdominal computed tomographyDietary qualityRisk DevelopmentLifestyle changesAlcohol intakeGenetic riskAbdominal computed tomographySocial determinants disadvantage score and liver health in the All of Us Research Program
Zhang X, Zhao L, Zhang K, Vlahov D, Chen Y, Hsing A, Nguyen M, McGlynn K, Taddei T, Hou L, Zhang X. Social determinants disadvantage score and liver health in the All of Us Research Program. European Journal Of Epidemiology 2026, 41: 207-216. PMID: 41579292, PMCID: PMC12975775, DOI: 10.1007/s10654-025-01358-y.Peer-Reviewed Original ResearchConceptsSocial determinants of healthUs Research ProgramOdds ratioSocial determinantsSocial determinants of health domainsDisadvantage scoreDeterminants of healthConfidence intervalsElectronic health recordsCross-sectional analysisHigh riskLogistic regression modelsSDOH domainsHealthcare accessHealth outcomesHealth recordsTargeted interventionsSocial disadvantageCommunity contextHealthLongitudinal studyRegression modelsQuintileLiver conditionsAssociation
2025
The impact of genetic and environmental risk factors on adverse liver outcomes
Zhang X, Zhao L, Campbell P, Chen Y, Fang A, Liu Z, Li X, Yang W, Fan J, Petrick J, McGlynn K, Lai M, Zhang X. The impact of genetic and environmental risk factors on adverse liver outcomes. International Journal Of Cancer 2025, 158: 2317-2328. PMID: 41345374, DOI: 10.1002/ijc.70259.Peer-Reviewed Original ResearchPolygenic risk scoresPopulation attributable riskPolygenic risk score tertileEnvironmental risk scoreRisk scoreUK Biobank participantsLevel of genetic predispositionRisk factorsEnvironmental risk factorsCancer RegistryBiobank participantsAttributable riskIncident outcomesLiver cancerGenetic riskHospital recordsTertileLiver cirrhosisGenetic predispositionFollow-upRiskLiver diseaseParticipantsLiver outcomesAdverse liver outcomesProteomic signatures of sweetened beverages are associated with higher risk of adverse liver outcomes
Zhao L, Zhang X, Zheng J, Chen Y, Haslam D, Zeng H, Bhupathiraju S, Hu F, Tobias D, McGlynn K, Zhang X. Proteomic signatures of sweetened beverages are associated with higher risk of adverse liver outcomes. Nature Food 2025, 6: 1186-1195. PMID: 41326748, DOI: 10.1038/s43016-025-01266-0.Peer-Reviewed Original ResearchConceptsPositively associated with riskArtificially sweetened beveragesAssociated with higher riskUK BiobankChronic liver disease mortalityConsumption of sweetened beveragesSweetened beverage intakeLiver disease mortalityCox proportional hazards regressionAssociation of sugarProportional hazards regressionAdverse liver outcomesBeverage intakeDisease mortalitySevere liver diseaseLiver outcomesLiver diseaseHazards regressionProteomic signatureRisk of adverse liver outcomesSteatotic liver diseaseMedian Follow-UpHealthFollow-upLiver healthCorrection to: Psychosocial symptom networks and high-risk sexual behaviors among men who have sex with men: a network analysis
Lin N, Guo Y, Chen Y, Yang Y, Lin H, Chen X, Wang T, Fu C, Wang S, Wang J. Correction to: Psychosocial symptom networks and high-risk sexual behaviors among men who have sex with men: a network analysis. BMC Psychology 2025, 13: 1314. PMID: 41310788, PMCID: PMC12659322, DOI: 10.1186/s40359-025-03753-2.Peer-Reviewed Original ResearchOverweight Modified the Associations between Long-Term Exposure to Ambient Fine Particulate Matter and Its Constituent and the Risk of Type 2 Diabetes in Rural China
Yang D, Chen Y, Meng X, Dong X, Kan H, Fu C. Overweight Modified the Associations between Long-Term Exposure to Ambient Fine Particulate Matter and Its Constituent and the Risk of Type 2 Diabetes in Rural China. Biomedical And Environmental Sciences 2025, 38: 1359-1368. PMID: 41368960, DOI: 10.3967/bes2025.136.Peer-Reviewed Original ResearchConceptsLong-term exposure to ambient fine particulate matterRisk of T2DMExposure to ambient fine particulate matterOverweight statusAmbient fine particulate matterFine particulate matterIncident type 2 diabetes mellitusRisk of incident type 2 diabetes mellitusHigher risk of T2DMRisk of type 2 diabetesBurden of T2DMRural ChinaParticulate matterHigh riskBlack carbonModification roleType 2 diabetes mellitusType 2 diabetesResidential exposureStratified analysisT2DM casesHazard ratioAmbient PMCox modelT2DMCumulative lipid exposure in young adulthood and risk of midlife MASLD
Chen Y, Zheng Y, Zhao L, Gao T, Qu Y, Carr J, Terry J, Ning H, Kim K, Long M, Zhang X, Wilkins J, Chen A, Zhang K, Allen N, Lloyd-Jones D, Hou L, Zhang X. Cumulative lipid exposure in young adulthood and risk of midlife MASLD. JHEP Reports 2025, 8: 101679. PMID: 41659770, PMCID: PMC12878633, DOI: 10.1016/j.jhepr.2025.101679.Peer-Reviewed Original ResearchLipoprotein cholesterolDNA methylation markersLipid levelsLipid exposureLiver diseaseAbdominal computed tomography scanAssociation of lipid profileCoronary Artery Risk DevelopmentNon-high-density lipoprotein cholesterolSteatotic liver diseaseYoung adulthoodMultivariable-adjusted odds ratioLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolDNA methylationModifiable risk factorsOptimal lipid levelsLongitudinal observational studyBlood DNA methylationExposure to lipidsEpigenomic biomarkersAbnormal triglyceridesLipid assessmentTomography scanRisk stratificationPsychosocial symptom networks and high-risk sexual behaviors among men who have sex with men: a network analysis
Lin N, Guo Y, Chen Y, Yang Y, Lin H, Chen X, Wang T, Fu C, Wang S, Wang J. Psychosocial symptom networks and high-risk sexual behaviors among men who have sex with men: a network analysis. BMC Psychology 2025, 13: 1252. PMID: 41225659, PMCID: PMC12613908, DOI: 10.1186/s40359-025-03550-x.Peer-Reviewed Original ResearchHigh-risk sexual behaviorCentral symptomsSociosexual desireSymptom networksSexual behaviorSelf-esteemMental healthSymptom-level associationsNetwork comparison testDemographic subgroupsSelf-report scalesModerate-to-severe depressionMethodsA cross-sectional surveySexual riskLow self-esteemModerate-to-severe anxietyAssociated with risky sexual behaviorCross-sectional surveyOnline snowball samplingBackgroundPsychosocial problemsRisky sexual behaviorHigh-risk behaviorsVenue-basedYoung MSMInternalized homonegativity
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