Yuka Takeo, PhD, DVM
Associate Research Scientist in GeneticsCards
About
Research
Publications
2025
The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection
Woo T, Takeo Y, Harwood M, Houck E, DiMaio D, Tsai B. The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection. Science Advances 2025, 11: eadz6792. PMID: 41124246, PMCID: PMC12542944, DOI: 10.1126/sciadv.adz6792.Peer-Reviewed Original ResearchConceptsC-terminal nuclear localization sequenceImportin 7Nuclear envelope breakdownNuclear entryCell-penetrating peptide sequenceTrafficking stepsImport machineryImport receptorMitotic nuclear envelope breakdownGolgi apparatusMitotic chromosomesGolgiCellular cargoEnvelope breakdownPeptide sequencesL2 proteinHuman papillomavirus infectionHuman papillomavirusRetrograde transportImportinChromosomeInfectionKnockdownNucleusProteinγ-secretase facilitates retromer-mediated retrograde transport
Takeo Y, Crite M, Mehmood K, DiMaio D. γ-secretase facilitates retromer-mediated retrograde transport. Journal Of Cell Science 2025, 138: jcs263538. PMID: 39865938, PMCID: PMC11883284, DOI: 10.1242/jcs.263538.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkTransport of protein cargoRetrograde protein traffickingCation-independent mannose-6-phosphate receptorCellular transmembrane proteinsMannose-6-phosphate receptorAssociation with cargoHuman epithelial cellsBinds retromerRetromer subunitsRetromer cargoRab7-GTPShiga toxinRetrograde transportCultured human epithelial cellsProtein traffickingRetromerCatalytic subunitTransmembrane domainTransmembrane proteinsProtein cargoCellular cargoTarget proteinsFunctional consequencesCholera toxin
2023
HPV is a cargo for the COPI sorting complex during virus entry
Harwood M, Woo T, Takeo Y, DiMaio D, Tsai B. HPV is a cargo for the COPI sorting complex during virus entry. Science Advances 2023, 9: eadc9830. PMID: 36662862, PMCID: PMC9858521, DOI: 10.1126/sciadv.adc9830.Peer-Reviewed Original ResearchConceptsCoat protein complex ITrans-Golgi networkProtein complex IGene knockdown strategyVirus entryCOPI complexProtein complexesCellular fractionationUnbiased proteomicsRetrograde traffickingCytoplasmic segmentGolgi stacksCellular cargoL2 mutantKnockdown strategyGolgi apparatusComplex IIncoming virusCell surfaceGolgiHost factorsCargoComplexesMutantsEndosomes
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