Yanzhi Feng
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Research
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Featured Publications
CAR-T-drug conjugate against solid tumor
Xin S, Feng Y, Zhang F, Yu J, Dong C, Tao B, Tang K, Wu Q, Chen B, Ren P, Verma N, Liu C, Suzuki K, Ling X, Park D, Kluger H, Crawford JM, Fan R, Zhou J, Chen S. CAR-T-drug conjugate against solid tumor. 2026 DOI: 10.64898/2026.01.02.696502.Peer-Reviewed Original ResearchMoving cellular therapies to the front line for Ph+ B cell acute lymphoblastic leukemia
Feng Y, Leveille E, Park J, Müschen M. Moving cellular therapies to the front line for Ph+ B cell acute lymphoblastic leukemia. Cell Reports Medicine 2025, 6: 102184. PMID: 40669449, PMCID: PMC12281393, DOI: 10.1016/j.xcrm.2025.102184.Commentaries, Editorials and Letters
2026
Rational design of immune gene therapy combinations via in vivo CRISPR activation screen of tumor microenvironment modulators.
Zhang F, Dong C, Chow R, Xin S, He E, Feng Y, Zhu L, Mirza D, Tian X, Yang L, Zhou L, Ling X, Han Q, Fan R, Chen S, Wang G. Rational design of immune gene therapy combinations via in vivo CRISPR activation screen of tumor microenvironment modulators. Cancer Discovery 2026 PMID: 41747251, DOI: 10.1158/2159-8290.cd-25-0545.Peer-Reviewed Original ResearchTherapy combinationsTumor microenvironmentAntigen presentationTCR-T cell therapyAnti-tumor immunityAnti-tumor responsesSolid tumors in vivoHostile tumor microenvironmentT cell proliferationT cell activationTumor microenvironment modulationTumors in vivoCAR-TCancer immunotherapyTumor infiltrationMetastatic tumorsTCR-TTherapeutic combinationsSolid tumorsCell therapyCo-StimulationTumorMicroenvironment modulationTNFSF9Activation of genes
2025
Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response
Zhang H, Hong L, Dong Z, Xin S, Lin B, Cheng J, Tian W, Li B, Wang J, Liu X, Liu C, Jin Y, Feng Y, Su G, Sun X, Liu Q, Dai X, Gao Y, Tong Z, Liu L, Zhu X, Zheng Y, Zhao P, Guo T, Fang W, Bao X. Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response. Cell Discovery 2025, 11: 60. PMID: 40593467, PMCID: PMC12219098, DOI: 10.1038/s41421-025-00811-2.Peer-Reviewed Original ResearchResident tissue macrophagesColorectal cancerImmunotherapy responseTumor microenvironmentNon-respondersCD4+ T cellsResistance to immunotherapyMetastatic colorectal cancerColorectal cancer microenvironmentMicrosatellite stabilityMHC-II expressionMicrosatellite instabilityT cell nicheCancer-associated fibroblastsMetastatic CRCImmunotherapy respondersT cellsImaging Mass CytometryAntigen presentationImmunotherapyCancer microenvironmentSingle-cell RNA sequencingMHC-IITissue macrophagesMass cytometryMultiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
Zhang F, Chow R, He E, Dong C, Xin S, Mirza D, Feng Y, Tian X, Verma N, Majety M, Zhang Y, Wang G, Chen S. Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nature Biotechnology 2025, 43: 2054-2067. PMID: 39820813, DOI: 10.1038/s41587-024-02535-2.Peer-Reviewed Original ResearchAdeno-associated virusTumor microenvironmentImmunosuppressive genesAntitumor efficacyCD8+ T cell infiltrationIn vivo antitumor efficacyCombinatorial cancer immunotherapyImmunosuppressive tumor microenvironmentSyngeneic tumor modelsT cell infiltrationTumor microenvironment remodelingMulti-agent combinationsMultiple tumor typesAntitumor immunityCombinatorial immunotherapyOptimal immunotherapyCancer immunotherapyGene alterationsTumor typesTumor modelReduced neutrophilLiver toxicityShRNA treatmentWhole-transcriptome profilingImmunotherapy
2023
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages
Ren P, Hu Y, Peng L, Yang L, Suzuki K, Fang Z, Bai M, Zhou L, Feng Y, Zou Y, Xiong Y, Chen S. Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages. Signal Transduction And Targeted Therapy 2023, 8: 281. PMID: 37518189, PMCID: PMC10387464, DOI: 10.1038/s41392-023-01509-1.Commentaries, Editorials and LettersPooled screening with next-generation gene editing tools
Zhou L, Yang L, Feng Y, Chen S. Pooled screening with next-generation gene editing tools. Current Opinion In Biomedical Engineering 2023, 28: 100479. PMID: 38222973, PMCID: PMC10786633, DOI: 10.1016/j.cobme.2023.100479.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGene editing toolsEditing toolsFunction of genesShort palindromic repeatsPooled screensPalindromic repeatsGenetic elementsPool of cellsBiological processesPooled screeningGenetic variantsPotential targetRecent advancesGenesRepeatsPlantsSequencingMutationsAgricultural researchTherapeutic interventionsSimultaneous examinationExpressionPotential future directionsCellsPool
2022
Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2
Fang Z, Peng L, Lucas C, Lin Q, Zhou L, Yang L, Feng Y, Ren P, Renauer PA, Monteiro VS, Hahn AM, Park JJ, Zhou X, Grubaugh N, Wilen C, Chen S. Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2. Cell Discovery 2022, 8: 69. PMID: 35853867, PMCID: PMC9295082, DOI: 10.1038/s41421-022-00435-w.Peer-Reviewed Original ResearchFGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis
Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L. FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2202631119. PMID: 35733256, PMCID: PMC9245619, DOI: 10.1073/pnas.2202631119.Peer-Reviewed Original ResearchConceptsFGF receptor 1VEGFA/VEGFR2 signalingSmall ubiquitin-like modifier (SUMO) modificationSUMOylation-defective mutantReceptor complex formationTyrosine kinase activationVEGFA/VEGFR2Endothelial cellsFGF/FGFRRegulatory featuresEmbryonic developmentTissue homeostasisSUMOylationReversible SUMOylationKinase activationFibroblast growth factorBasic fibroblast growth factorFRS2αVascular developmentVEGFR2 signalingContradictory phenotypesEndothelial sproutingAngiogenic signalingFunctional significanceProangiogenic stimuli