Suet Yin Sarah Fung
Associate Research Scientist in Cell BiologyAbout
Research
Publications
2026
STIM1 and endoplasmic reticulum–plasma membrane contact sites oscillate independently of calcium-induced calcium release
Xiong D, Tong C, Fung S, McClellan S, Yang Y, Yong J, Wu M. STIM1 and endoplasmic reticulum–plasma membrane contact sites oscillate independently of calcium-induced calcium release. Open Biology 2026, 16: 250220. PMID: 41844235, DOI: 10.1098/rsob.250220.Peer-Reviewed Original ResearchConceptsStromal interaction molecule 1ER-plasma membraneReceptor activationCalcium-induced calcium releaseER-PM contact sitesPlasma membraneContact sitesProportion of cellsIntracellular storesCalcium releaseOrai1 channelsEndoplasmic reticulum-plasma membrane contact sitesMolecule 1Mast cellsCortical oscillationsMembrane contact sitesTotal internal reflection fluorescence microscopyReceptorsER-plasmaCortical mechanismsPlasmaNon-physiological conditionsSite dynamicsReleaseCells
2024
Nonlinear dynamics in phosphoinositide metabolism
Fung S, Xǔ X, Wu M. Nonlinear dynamics in phosphoinositide metabolism. Current Opinion In Cell Biology 2024, 88: 102373. PMID: 38797149, PMCID: PMC11186694, DOI: 10.1016/j.ceb.2024.102373.Peer-Reviewed Original ResearchMetabolic networksPhosphoinositide metabolismNegative feedback loopCellular physiologyEnzymatic functionSignaling ComplexSignal transductionMembrane dynamicsNetwork motifsMetabolic pathwaysLipid fluxCellular behaviorMolecular circuitsPhosphoinositideFeedforward loopProducts of metabolismMetabolismFeedback loopExperimental challengeNonlinear dynamicsMotifFramework of nonlinear dynamicsTransductionExcited statesComprehensive understanding
2016
Opposing Activities of Aurora B Kinase and B56-PP2A Phosphatase on MKlp2 Determine Abscission Timing
Fung S, Kitagawa M, Liao P, Wong J, Lee S. Opposing Activities of Aurora B Kinase and B56-PP2A Phosphatase on MKlp2 Determine Abscission Timing. Current Biology 2016, 27: 78-86. PMID: 27939310, DOI: 10.1016/j.cub.2016.10.042.Peer-Reviewed Original ResearchConceptsAurora B phosphorylationAurora B kinaseB56-PP2AAurora BIntercellular bridgesPlasma membraneB kinaseOpposing activitiesCleavage furrow ingressionActivity of Aurora B kinaseNascent daughter cellsPP2A phosphatase activityFurrow ingressionESCRT complexesMicrotubule cytoskeletonAbscission timingMammalian cellsMKlp2Association motifDaughter cellsComplete abscissionCell divisionAssembly platformAbscissionMidbody
2015
Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency
Farah B, Landau D, Sinha R, Brooks E, Wu Y, Fung S, Tanaka T, Hirayama M, Bay B, Koeberl D, Yen P. Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. Journal Of Hepatology 2015, 64: 370-379. PMID: 26462884, DOI: 10.1016/j.jhep.2015.10.008.Peer-Reviewed Original ResearchConceptsLipid over-accumulationInduction of autophagyOver-accumulationOxidative phosphorylationGlucose-6-phosphataseHepatic cellsCanine modelCell culturesGlucose-6-phosphateHepatic lipid metabolismDogsUnc51-like kinase 1Hepatic cell linesAMPK pathwayFatty acid b-oxidationGlycogen contentMarkers of liver damageKinase 1Intracellular lipid storesPharmacological induction of autophagyLipid accumulationLipid storesLiver sizePharmacological inductionCell lines
2014
Cdk1 Coordinates Timely Activation of MKlp2 Kinesin with Relocation of the Chromosome Passenger Complex for Cytokinesis
Kitagawa M, Fung S, Hameed U, Goto H, Inagaki M, Lee S. Cdk1 Coordinates Timely Activation of MKlp2 Kinesin with Relocation of the Chromosome Passenger Complex for Cytokinesis. Cell Reports 2014, 7: 166-179. PMID: 24656812, DOI: 10.1016/j.celrep.2014.02.034.Peer-Reviewed Original ResearchConceptsChromosomal passenger complexPassenger complexMitotic progressionAnaphase chromosomesC-terminal tailChromosomal targetsMicrotubule bindingGenome stabilityPhosphorylation sitesAnaphase onsetCdk1/cyclin B1Mitotic transitionMKlp2ChromosomeCell equatorCytokinesisAnaphasePhosphoregulationComplex formationCDK1KinesinPhosphorylation
2013
Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis
Kitagawa M, Fung S, Onishi N, Saya H, Lee S. Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for Cytokinesis. PLOS ONE 2013, 8: e64826. PMID: 23750214, PMCID: PMC3672163, DOI: 10.1371/journal.pone.0064826.Peer-Reviewed Original ResearchConceptsTargeting Aurora BEquatorial cortexAurora BCell cortexMonopolar cytokinesisIngressing furrowMyosin IICleavage furrowFurrow formationAurora B kinase activityCleavage furrow ingressionFurrow ingressionActive RhoACell polarityMKlp2Mammalian cellsCytokinesisKinase activityRecruitment eventsMutantsCleavageCellsFurrowRhoAKinase