Sudheesh A P, PhD
he/him/his
Associate Research Scientist Molecular Cellular and Developmental BiologyDownloadHi-Res Photo
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Associate Research Scientist Molecular Cellular and Developmental Biology
Biography
I am a and ambitious researcher who is trying to apply the knowledge from basic research to understand complex disease-relevant questions. I completed my Ph.D. studying eukaryotic mRNA 3'-end processing and currently trying to understand the role of regulatory RNAs in stem cells and regeneration.
Last Updated on November 16, 2022.
Appointments
Molecular, Cellular, and Developmental Biology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- Rajiv Gandhi Centre for Biotechnology, RNA Biology (2019)
- MSc
- Mahatma Gandhi University, Biotechnology (2012)
- BSc
- Bharathiar University, Biotechnology (2010)
Research
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Overview
I am trying to understand the role of small regulatory RNAs in Planarians.
ORCID
0000-0002-1632-147X- View Lab Website
Van Wolfswinkel
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sudheesh A P's published research.
Publications Timeline
A big-picture view of Sudheesh A P's research output by year.
Josien van Wolfswinkel, PhD, MSc
6Publications
56Citations
Publications
2025
Enhanced RNA quality control maintains long-term regenerative ability in planarians
Zelko M, Li D, Parambil S, Poulet A, Verdesca A, Mazeika K, Dasgupta K, van Wolfswinkel J. Enhanced RNA quality control maintains long-term regenerative ability in planarians. Development 2025, 152: dev204762. PMID: 40955864, PMCID: PMC12579931, DOI: 10.1242/dev.204762.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSignal recognition particleNon-coding RNAsRegulation of non-coding RNAsRNA quality controlAccumulation of RNAIntracellular protein aggregatesAberrant RNAsCellular machineryGerm cellsNon-codingProtein secretionProtein aggregationRNALong-lived cellsPlanariansRibonucleoproteinProgressive lossNeoblastsRegenerative abilityCellsWound repairProteostasisHomologyStem cellsAccumulationOp-Ed: From Research to Reality: The Personal Cost of Academia
Parambil S, Ramu M. Op-Ed: From Research to Reality: The Personal Cost of Academia. Journal Of Life Sciences 2025 DOI: 10.36069/jols/20250503.Peer-Reviewed Original ResearchBiology of Hox Genes: Questions and Technological Challenges
Parambil S, De Kumar B. Biology of Hox Genes: Questions and Technological Challenges. Methods In Molecular Biology 2025, 2889: 1-10. PMID: 39745601, DOI: 10.1007/978-1-0716-4322-8_1.Peer-Reviewed Original Research
2023
piRNA generation is associated with the pioneer round of translation in stem cells
Parambil S, Li D, Zelko M, Poulet A, van Wolfswinkel J. piRNA generation is associated with the pioneer round of translation in stem cells. Nucleic Acids Research 2023, 52: 2590-2608. PMID: 38142432, PMCID: PMC10954484, DOI: 10.1093/nar/gkad1212.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSMEDWI-1Pioneer roundStem cellsPlanarian stem cellsStem cell maintenanceStem cell stateNon-coding transcriptsPiRNA pathwayPIWI proteinsTransposon repressionBiogenesis pathwayPiRNA generationGenomic integritySmall RNAsCell maintenanceSuch transcriptsCell statesCytoplasmic poolTranscriptsCell coloniesCell healthPiRNAsDynamic poolTranscriptomeCells
2019
Star-PAP controlled alternative polyadenylation coupled poly(A) tail length regulates protein expression in hypertrophic heart
Sudheesh A, Mohan N, Francis N, Laishram R, Anderson R. Star-PAP controlled alternative polyadenylation coupled poly(A) tail length regulates protein expression in hypertrophic heart. Nucleic Acids Research 2019, 47: 10771-10787. PMID: 31598705, PMCID: PMC6847588, DOI: 10.1093/nar/gkz875.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStar-PAPMRNA isoformsPoly(A) tail lengthPoly(A) sitePoly(A) tailDistal-mostMolecular eventsProtein expressionLoss of NQO1APA sitesPre-mRNAShorter transcriptTerminal exonNQO1 transcriptionRegulatory sitesNQO1 isoformsEctopic expressionTarget genesTranscriptionIsoformsNQO1 proteinProteinPoly(ATail lengthDistal-most sites
2018
Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion
Sudheesh A, Laishram R. Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion. Molecular And Cellular Biology 2018, 38: e00457-17. PMID: 29203642, PMCID: PMC5809686, DOI: 10.1128/mcb.00457-17.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsBreast NeoplasmsCell Line, TumorCell NucleusFemaleHumansMCF-7 CellsNeoplasm InvasivenessNucleotidyltransferasesPhosphatesPhosphatidylinositol 3-KinasePhosphatidylinositol PhosphatesPhosphorylationPolyadenylationPolynucleotide AdenylyltransferaseProtein BindingRNA PrecursorsRNA Processing, Post-TranscriptionalRNA, MessengerConceptsPoly(A) polymeraseStar-PAPCellular invasionGene expressionInvasive MDA-MB-231 cellsRegulation of cancer cell invasionCell invasionInvasion of breast cancer cellsMDA-MB-231 cellsAnti-invasive mechanismCancer cell invasionBreast cancer cellsPre-mRNANuclear phosphatidylinositolAnti-invasive factorsLevel-dependent mannerS6 phosphorylationMCF7 cellsKinase ACancer cellsMutantsBreast cancerPhosphatidylinositolExpressionInvasion
Academic Achievements & Community Involvement
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Honors
honor The Joan and Tom Steitz Fellowship
03/04/2023Other AwardYale Center for RNA Science and MedicineDetailsUnited States
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Contacts
Mailing Address
Yale University
Sudheesh A P, Ph.D., Van Wolfswinkel Lab, 266 Whitney Ave, Bass receiving, Yale Science Building
New Haven, Connecticut 06511
United States