Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsStephanie Wu
Clinical InstructorAbout
Research
Publications
2025
A benchmarking study of copy number variation inference methods using single-cell RNA-sequencing data
Chen X, Fang L, Chen Z, Chen W, Wu H, Zhu B, Moos M, Farmer A, Zhang X, Xiong W, Gong S, Jones W, Mason C, Wu S, Xiao C, Wang C. A benchmarking study of copy number variation inference methods using single-cell RNA-sequencing data. Precision Clinical Medicine 2025, 8: pbaf011. PMID: 40584741, PMCID: PMC12204187, DOI: 10.1093/pcmedi/pbaf011.Peer-Reviewed Original ResearchScRNA-seq datasetsStudy genetic heterogeneityScRNA-seq dataCopy number variationsSingle-cell RNA sequencingRNA sequencing dataInference methodsRead lengthSequencing depthSingle-cell levelSequencing tissueScRNA-seqTranscriptome dataNumber variationsGenetic heterogeneityRNA sequencingBatch effectsHuman lung adenocarcinoma cell lineLung adenocarcinoma cell linesAdenocarcinoma cell lineCell linesInferCNVCancer researchSCCNVTumor heterogeneityPGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus
Li Y, Ma H, Zhang Y, He T, Li B, Ren H, Feng J, Sheng J, Li K, Qian Y, Wang Y, Zhao H, He J, Li H, Wu H, Yao Y, Shi M. PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus. Journal Of Clinical Investigation 2025, 135: e188083. PMID: 39946201, PMCID: PMC11996887, DOI: 10.1172/jci188083.Peer-Reviewed Original ResearchHepatitis B virusHBV clearanceSpontaneous clearance of hepatitis B virusB virusClear hepatitis B virusClearance of hepatitis B virusHepatitis B virus infectionSpontaneous HBV clearanceAnti-HBV treatmentDNA-binding domainInhibit HBV replicationCovalently closed circular DNAPattern recognition receptorsPotential therapeutic strategyFunctional cureSpontaneous clearanceHost-virus interactionsAge-dependent expressionPathogenic variantsPGRP domainHBV replicationTherapeutic strategiesRecognition receptorsNucleocytoplasmic translocationPGLYRP2
2023
Editorial: Gut-liver-brain axis: a complex network influences human health and diseases
Wu H, Zhang Y, Yu J, Shi M. Editorial: Gut-liver-brain axis: a complex network influences human health and diseases. Frontiers In Neuroscience 2023, 17: 1241069. PMID: 37521705, PMCID: PMC10374336, DOI: 10.3389/fnins.2023.1241069.Peer-Reviewed Original Research
2021
Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells
Li Y, Harunori O, Fu S, Xing F, Wu H, Wang J, Chen A, Ren X, Peng D, Ling X, Shi M, Wu H. Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells. Aging 2021, 13: 20131-20148. PMID: 34461606, PMCID: PMC8436936, DOI: 10.18632/aging.203279.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAgedAntigensCD3 ComplexCD56 AntigenCD8-Positive T-LymphocytesCell Culture TechniquesHealth StatusHumansImmune SystemImmunityImmunotherapyKiller Cells, NaturalLeukocytes, MononuclearLymphomaMiddle AgedNeoplasmsPancreatic NeoplasmsProgrammed Cell Death 1 ReceptorReceptors, IgGT-Lymphocytes, Helper-InducerTreatment OutcomeConceptsPeripheral blood mononuclear cellsPD-1+ T cellsProgrammed cell death protein 1Sub-healthy individualsNKM cellsImmune normalizationT cellsCD8+ PD-1+ T cellsCancer patientsCell death protein 1Proportion of NK cellsProportion of T helper cellsPeripheral immune systemT helper cellsBlood mononuclear cellsPotential clinical applicationsMalignant lymphomaNK cellsAdjuvant treatmentKiller cellsPancreatic cancerMononuclear cellsEfficacious therapyCancer preventionSide effects
2019
Single-Cell Intratumoral Stemness Analysis Reveals the Involvement of Cell Cycle and DNA Damage Repair in Two Different Types of Esophageal Cancers
Wu H, Li Y, Hou Q, Zhou R, Li Z, Wu S, Yu J, Jiang M. Single-Cell Intratumoral Stemness Analysis Reveals the Involvement of Cell Cycle and DNA Damage Repair in Two Different Types of Esophageal Cancers. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s175. DOI: 10.1016/j.ijrobp.2019.06.209.Peer-Reviewed Original Research
2018
Patient Derived Xenografts Demonstrate the Radiosensitizing Effect of Inhibiting MAPK Signaling Pathway in Pancreatic Ductal Adenocarcinoma
Zhang H, Jiang Z, Yue J, Yu J, Wu H, Zhang X, Yang L, Zheng X, Jiang M, Hua Y, Hou Q, Huang M, Li Y, Wu S. Patient Derived Xenografts Demonstrate the Radiosensitizing Effect of Inhibiting MAPK Signaling Pathway in Pancreatic Ductal Adenocarcinoma. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e188-e189. DOI: 10.1016/j.ijrobp.2018.07.685.Peer-Reviewed Original Research
2017
Targeting CAFs-Secreted TGFβ1 Signaling to Radiosensitize Esophageal Squamous Cell Carcinoma In Vitro and In Vivo
Zhang H, Yue J, Jiang Z, Wu H, Zhang X, Yang L, Jiang M, Hua Y, Li Y, Huang M, Hou Q, Li W, Wu S. Targeting CAFs-Secreted TGFβ1 Signaling to Radiosensitize Esophageal Squamous Cell Carcinoma In Vitro and In Vivo. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s149. DOI: 10.1016/j.ijrobp.2017.06.346.Peer-Reviewed Original ResearchSingle-Cell Transcriptome Analyses Reveal Taxol Resistant Subpopulations in Esophageal Squamous Cancer Cells
Wu H, Yu J, Chen S, Zhang X, Yang L, Zhang H, Li Y, Hou Q, Hua Y, Jiang M, Wang C, Wu S. Single-Cell Transcriptome Analyses Reveal Taxol Resistant Subpopulations in Esophageal Squamous Cancer Cells. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e627-e628. DOI: 10.1016/j.ijrobp.2017.06.2115.Peer-Reviewed Original ResearchClonal Evolution of Radioresistance in Esophageal Squamous Cell Carcinoma by Single-Cell Whole Exome Sequencing
Yang L, Zhang X, Wu H, Li Y, Zhang H, Jing Z, Hou Q, Jiang M, Hua Y, Vijay P, Mason C, Wu S. Clonal Evolution of Radioresistance in Esophageal Squamous Cell Carcinoma by Single-Cell Whole Exome Sequencing. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s198-s199. DOI: 10.1016/j.ijrobp.2017.06.493.Peer-Reviewed Original ResearchSingle-Cell Transcriptome Analyses Reveal Signals to Radio-Resistance in Esophageal Squamous Cell Carcinoma
Wu H, Yang L, Zhang X, Zhang H, Li Y, Hou Q, Jiang Z, Hua Y, Jiang M, Brunicardi C, Yu J, Wu S. Single-Cell Transcriptome Analyses Reveal Signals to Radio-Resistance in Esophageal Squamous Cell Carcinoma. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e627. DOI: 10.1016/j.ijrobp.2017.06.2114.Peer-Reviewed Original Research