Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsStephanie Eisenbarth, MD, PhD
Associate Professor AdjunctDownloadHi-Res Photo
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Titles
Associate Professor Adjunct
Biography
Dr. Eisenbarth’s laboratory focuses on how dendritic cells, B cells and T cells interact to induce tailored adaptive immune responses. The work spans how this triad is operational in the spleen to transfused red blood cells (RBCs), in the lung to aeroallergens, and in the gut to food allergens, utilizing both mouse models and human samples.
Last Updated on February 06, 2024.
Appointments
Laboratory Medicine
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Yale University (2010)
- Resident
- Yale New Haven Hospital (2008)
- MD
- Yale School of Medicine (2005)
- PhD
- Yale University (2003)
- BA
- Bryn Mawr College (1996)
Research
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Overview
Medical Research Interests
Allergy and Immunology; Asthma; Blood Group Incompatibility; Food Hypersensitivity; Immune System Diseases
ORCID
0000-0002-1244-208X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie Eisenbarth's published research.
Publications Timeline
A big-picture view of Stephanie Eisenbarth's research output by year.
Research Interests
Research topics Stephanie Eisenbarth is interested in exploring.
Elise Liu, MD, PhD
Laura Rose Hoyt
Joseph Craft, MD
Shuting Chen
Christine Dien
Craig B. Wilen, MD, PhD
24Publications
117Citations
Food Hypersensitivity
Publications
2026
Extrafollicular and other non-germinal center B cell responses.
Eisenbarth S, Ashby K, Ojo O, Williams A. Extrafollicular and other non-germinal center B cell responses. The Journal Of Immunology 2026, 215 PMID: 41764717, DOI: 10.1093/jimmun/vkaf336.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsB cell responsesGerminal centersEF B-cell responseB cell folliclesT cell-dependentB cell activation pathwaysB cell biologyPathogenic antibodiesB cellsImmune stimuliHumoral immunityFunctional outcomesAnatomical locationImmune responseAntibody responseHuman studiesActivation pathwayDevelopmental cuesMolecular mechanismsActivation/differentiationResponseMiceFolliclesDOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells
Siniscalco E, Fisher C, Lu M, Grassmann J, Mack C, Yaakoubi R, Jacobsen D, Chen Q, Lee D, Rajamanimuthu P, Simoneau T, Preece K, Gray P, Okada S, Boisson B, Kayaoglu B, Danielson J, Freeman A, Casanova J, Chatila T, Su H, S. C, Williams A, Eisenbarth S, Gowthaman U. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. Journal Of Experimental Medicine 2026, 223: e20241707. PMID: 41604592, PMCID: PMC12883044, DOI: 10.1084/jem.20241707.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeanut-specific IgEDOCK8 deficiencyT Follicular Helper CellsFood-specific IgEHyper-IgE syndromeCell-specific deletionSymptomatic allergyTreg depletionTreg impairmentOral antigensHelper cellsT cellsPeanut exposureOral sensitizationCell inductionDOCK8TregsFood allergensIgEMicePatientsSTAT3 variantsAllergyDeficiencySTAT3 activation
2025
Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues
Olson E, Williams A, Eisenbarth S. Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues. Immunological Reviews 2025, 337: e70080. PMID: 41319117, PMCID: PMC12665179, DOI: 10.1111/imr.70080.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsT cell responsesDendritic cellsDC migrationImmune surveillanceLymphoid tissueImmune surveillance of tissuesRegional lymph nodesCytoskeletal rearrangementsAdaptive immune responsesChemoattractant moleculesAdaptive immune systemDynamic cytoskeletal rearrangementsDC subsetsReceptor expressionLymph nodesDiverse tissue environmentsAdaptive immunityImmune responseBarrier sitesImmune systemWhite pulpChemotactic receptorsTissueReceptorsTissue environmentSequential class switching generates antigen-specific gut IgA from IgG1 B cells
Siniscalco E, Meng H, Gabernet G, Pacheco G, Saghaei S, Ramirez S, Hills L, Faraji F, Chen S, Yin X, Dien C, Hoyt L, Liu E, Barrett A, Briggs N, Williams A, Shukla V, Crotty S, Wesemann D, Kleinstein S, Craft J, Eisenbarth S. Sequential class switching generates antigen-specific gut IgA from IgG1 B cells. Immunity 2025, 58: 3075-3093.e6. PMID: 41253159, PMCID: PMC12834128, DOI: 10.1016/j.immuni.2025.10.022.Peer-Reviewed Original ResearchThis study investigates how gut-specific IgA antibodies are generated from IgG1 B cells through sequential class switching, highlighting a crucial mechanism for designing effective mucosal vaccines.DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells 3840
Ashby K, Siniscalco E, Fisher C, Williams A, Uthaman G, Eisenbarth S. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells 3840. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.1595.Peer-Reviewed Original ResearchConceptsDedicator of cytokinesis 8T cellsImpairment of regulatory T cellsT Follicular Helper CellsCD4+ T cellsFood-specific IgE.Hyper-IgE responseFood-specific IgET follicular helperRegulatory T cellsPeanut-specific IgEAllergen-specific immunoglobulin ELife-threatening anaphylaxisHelper cellsFood allergyImmediate hypersensitivityIgE inductionIgE productionImmune responseAllergic responsesImmunoglobulin EMast cellsMonogenic diseasesDN mutationsIgELarge language models accurately identify immunosuppression in intensive care unit patients
Guggilla V, Kang M, Bak M, Tran S, Pawlowski A, Nannapaneni P, Rasmussen L, Schneider D, Donnelly H, Agrawal A, Liebovitz D, Misharin A, Budinger G, Wunderink R, Walunas T, Gao C, Hauser A, Peltekian A, Misharin A, Wolfe A, Szabo A, Choudhary A, Ludwig A, Moghadam A, Yeldandi A, Agrawal A, Bharat A, Pawlowski A, Joudi A, Tambe A, Smith-Nunez A, Singer B, Ulrich B, Tran B, Gottardi C, Gao C, Qi C, Pickens C, Schroedl C, Meza D, Schneider D, Garcia D, Ozer E, Gusman E, Shanes E, Leibenguth E, Olson E, Hartmann E, Korth E, Diaz E, Guzman E, Martinez F, Matias G, Budinger G, Donnelly H, Abdala-Valencia H, Sumner J, Sznajder J, Kruser J, Glowala J, Walter J, Rowell J, Arnold J, Coleman J, Lomasney J, Bailey J, Hultquist J, Fiala J, Starren J, Ridge K, Senkow K, Helmin K, Gates K, Simmons L, Pinzon L, Gradone L, Wolfe L, Luo L, Morales-Nebreda L, Rasmussen L, Jain M, Sala M, Schleck M, Ross M, Querrey M, Kang M, Cuttica M, Prickett M, Nadig N, Rhodes N, Chandel N, Markov N, Sporn P, Nannapaneni P, Liu Q, Kadar R, Medernach R, Lorenzo-Redondo R, Kalhan R, Clepp R, Wunderink R, Morimoto R, Grant R, Mylvaganam R, Fenske S, Laurenzo S, Smith S, Han S, Nozick S, Panchamukhi S, Eisenbarth S, Swaminathan S, Russell S, Poor T, Cybulski T, Lombardo T, Walunas T, Bolig T, Stoeger T, Doan T, Rowe T, Guggilla V, Liao W, Luo Y, Sokolenko Y, Yu Z, Lu Z. Large language models accurately identify immunosuppression in intensive care unit patients. Journal Of The American Medical Informatics Association 2025, 32: 1888-1898. PMID: 40977378, PMCID: PMC12490808, DOI: 10.1093/jamia/ocaf141.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNatural language processing approachNatural language processingF1 scoreData algorithmLanguage modelHeterogeneous typesIntensive care unitIntensive care unit patientsLanguage processingImmunosuppressive conditionsMedication ordersPrimary cohortClinical notesPoor generalizabilityCohort identificationAlgorithmDiagnosis codesValidation cohortHospital admission notesType of immunosuppressionCodeBeth Israel Deaconess Medical CenterImmunosuppressive medication useRobust external validationNorthwestern Memorial HospitalA roadmap for defining “extrafollicular” B cell responses
Eisenbarth S, Batista F, Cyster J, Elsner R, Kelsoe G, Lund F, Pillai S, Sanz I, Shlomchik M, Toellner K, Vinuesa C, Baumgarth N. A roadmap for defining “extrafollicular” B cell responses. Immunity 2025, 58: 2627-2645. PMID: 40987283, DOI: 10.1016/j.immuni.2025.08.007.Peer-Reviewed Original ResearchCitationsAltmetricExtrafollicular and Other Non‐Germinal Center B Cell Responses: An Evolutionary Perspective
Flowers E, Siniscalco E, Eisenbarth S. Extrafollicular and Other Non‐Germinal Center B Cell Responses: An Evolutionary Perspective. Immunological Reviews 2025, 334: e70060. PMID: 40938272, PMCID: PMC12801160, DOI: 10.1111/imr.70060.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGerminal centersHumoral immunityMultiple generaImmunological foundationsVertebrate evolutionAdjacent T cellsB cell responsesB cell proliferationB-cell regionsGC-independent pathwayMammalsT cellsHumoral protectionMechanisms of humoral immunityGC responsePathwayProtective antibodiesOrgan sitesAntibody responseAntigen depositionAntibodiesGenusCysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
Hoyt L, Liu E, Olson E, Jacobsen D, Siniscalco E, Krier-Burris R, Greenfield K, McBride C, Alfajaro M, Amat J, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger D, Zhang L, Bunyavanich S, Glass S, Coffey R, Wilen C, Williams A, Eisenbarth S. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. Science 2025, 389: eadp0240. PMID: 40773557, PMCID: PMC12333546, DOI: 10.1126/science.adp0240.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFood-specific immunoglobulin ESensitivity to anaphylaxisFood-specific IgEResistant C57BL/6 miceFood allergensLife-threatening anaphylaxisStrains of miceGut absorptionOral anaphylaxisSusceptible miceResistant miceC57BL/6 miceCysteinyl leukotrienesAllergen consumptionAllergic sensitizationFood allergyImmunoglobulin EAllergen absorptionAnaphylaxisIntestinal epitheliumMiceIntestinal goblet cellsAllergen transportSynthesis inhibitorGoblet cellsTolerance requires diversity (of antigen presenting cells).
Jacobsen D, Eisenbarth S. Tolerance requires diversity (of antigen presenting cells). Science Immunology 2025, 10: eady4136. PMID: 40315295, DOI: 10.1126/sciimmunol.ady4136.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
Academic Achievements & Community Involvement
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activity American Society for Clinical Investigation
04/17/2020 - PresentProfessional OrganizationsMember
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News
- February 26, 2024
Elise Liu Receives 2024 AAAAI Foundation Faculty Development Award
- May 08, 2023
Liu Wins ASCI Emerging-Generation Award
- October 28, 2022
Meet Yale Allergy & Immunology: Jake Kuster, MD, and Elise Liu, MD
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