Siyan Fan
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2025
Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study
Asch R, Fan S, Cool R, Boster S, DellaGioia N, Naganawa M, Nabulsi N, Lacadie C, Pietrzak R, Esterlis I. Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET–MRI Study. Biological Psychiatry 2025 PMID: 41325959, PMCID: PMC12981349, DOI: 10.1016/j.biopsych.2025.11.018.Peer-Reviewed Original ResearchGray matter volumeBipolar disorderMedication effectsNeural signaturesPsychotropic medicationsFronto-limbic brain regionsAssociated with greater impulsivityPositron emission tomographyC]UCB-J positron emission tomographyNeurobiology of bipolar disorderSynaptic densitySynaptic vesicle glycoprotein 2AIllness-related changesMatter volumeSV2A densityBD individualsBrain regionsFunctional MRIBrain structuresGroup differencesSynaptic deficitsNeuroimaging findingsPET-MRI studiesMedical statusIn vivo evidence
2024
Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5
2023
Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake
Fan S, Goldfarb E, Lacadie C, Fogelman N, Seo D, Sinha R. Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake. Neurobiology Of Stress 2023, 25: 100540. PMID: 37323647, PMCID: PMC10265520, DOI: 10.1016/j.ynstr.2023.100540.Peer-Reviewed Original ResearchGray matter volumeDorsal lateral prefrontal cortexAlcohol use disorderSmaller gray matter volumeAlcohol intakePrefrontal gray matter volumeBinge drinkingFuture alcohol intakeMatter volumeBilateral dorsal lateral prefrontal cortexCortisol levelsStructural grey matter volumeHigher cortisolWhole-brain voxel-based morphometryAcute alcohol intakeLower gray matter volumeHigh-resolution structural MRIVoxel-based morphometryRegional gray matter volumePosterior parietal cortexMotor cortexSupplementary motorModerate drinkersUse disordersDrinking days
2020
Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder
Fan S, Nemati S, Akiki TJ, Roscoe J, Averill CL, Fouda S, Averill LA, Abdallah CG. Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder. Chronic Stress 2020, 4: 2470547020984726. PMID: 33458556, PMCID: PMC7783890, DOI: 10.1177/2470547020984726.Peer-Reviewed Original ResearchTreatment modalitiesSymptom improvementConnectome fingerprintPrognostic predictionMajor depressive disorder treatmentMonths of treatmentLower remission rateDepressive disorder treatmentMajor depressive disorderDrug developmentFunctional magnetic resonance imagingMagnetic resonance imagingFunctional connectome fingerprintTreatment-specific improvementsNovel drug developmentDefault mode networkRemission rateAntidepressant responsePretreatment biomarkersDaily treatmentPersonalized medicineUnmedicated patientsDepressive disorderWeek 8Treatment response
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