Siqi Zhang
Associate Research ScientistCards
About
Research
Publications
2026
Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States A Population-Based Cohort Study
Zhang S, Wang Y, Wei J, Benmarhnia T, Liu Y, Krumholz H, Lu Y, Chen K. Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States A Population-Based Cohort Study. Journal Of The American College Of Cardiology 2026 PMID: 41706074, DOI: 10.1016/j.jacc.2025.12.079.Peer-Reviewed Original ResearchThis study investigates how long-term exposure to wildfire smoke particles (PM2.5) increases cardiovascular hospitalizations in older adults, highlighting the need for targeted health strategies.
2025
Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults
Chen H, Zhang S, Pan X, Schneider A, Diaz-Sanchez D, Samet J, Tong H. Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults. Toxics 2025, 13: 1063. PMID: 41441285, PMCID: PMC12737357, DOI: 10.3390/toxics13121063.Peer-Reviewed Original ResearchExposure to PM2.5Short-term air pollution exposureAir pollution exposurePollution exposureAir pollutionAmbient air pollution exposureExposure to air pollutionMixed-effects modelsPollutionN-3 FA groupElevated levelsPlasma concentrationsExposureParticipants' plasma samplesN-3 groupFA groupSpeciesHealthy adultsAssociated with systemic inflammationPro-inflammatory oxylipinsN-3Fatty acid intakeFatty acidsShort-Term Exposure to Low and High Temperatures and Mortality Among Patients With Heart Failure in Sweden
Ni W, Benson L, Ljungman P, Nobile F, Breitner S, Zhang S, de Bont J, Lund L, Savarese G, Schneider A, Agewall S. Short-Term Exposure to Low and High Temperatures and Mortality Among Patients With Heart Failure in Sweden. JAMA Cardiology 2025, 10: 1276-1284. PMID: 41123904, PMCID: PMC12547678, DOI: 10.1001/jamacardio.2025.3932.Peer-Reviewed Original ResearchConceptsCase-crossover studyAll-CauseOdds ratioCardiovascular mortalityCause of Death RegisterRisk of all-causeSwedish National Patient RegisterNational Patient RegisterAll-Cause MortalityStudy periodComorbid atrial fibrillationDeath RegisterAssociated with mortalityPatient RegisterMain OutcomesComorbid diabetesExposure to ambient temperatureDiuretic usersHeart failurePrimary outcomeSwedish patientsMortalityShort-term exposureAssociationRegisterImprovements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change
Huber V, Breitner-Busch S, Feldbusch H, Frieler K, He C, Matthies-Wiesler F, Mengel M, Zhang S, Peters A, Schneider A. Improvements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change. Nature Communications 2025, 16: 11632. PMID: 41298519, PMCID: PMC12748886, DOI: 10.1038/s41467-025-66681-0.Peer-Reviewed Original ResearchExcess mortalityLife expectancyTemperature-mortality associationsAssociated with improvementsHealth outcomesClimate changeDeath burdenAttribution studiesHuman health outcomesTemporal trendsStudy periodNon-climatic driversReanalysis seriesAnthropogenic fingerprintSummer warmingTemperature dataMortalityLifeDoes personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study
Pulczinski J, Zhang S, Breen M, Breen M, Isakov V, Schneider A, Rappold A, Diaz-Sanchez D, Devlin R, Samet J, Tong H. Does personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study. Ecotoxicology And Environmental Safety 2025, 307: 119422. PMID: 41260034, DOI: 10.1016/j.ecoenv.2025.119422.Peer-Reviewed Original ResearchConceptsAir quality monitoringAmbient air pollutionAir pollutionExposure-response relationshipAccurate exposure assessmentLag0Exposure modelExposure assessmentCardiopulmonary biomarkersQuality monitoringPollutionMixed-effects modelsExposureLag4Lag1Cardiopulmonary diseaseNegative associationConcentrationPositive associationAirAssociations of Long-Term Exposure to Temperature Variability with Glucose Metabolism: Results from KORA F4 and FF4
Ni W, Zhang S, Herder C, Breitner-Busch S, Wolf K, Liao M, Nikolaou N, Pickford R, Koenig W, Rathmann W, Schwettmann L, Roden M, Thorand B, Peters A, Schneider A. Associations of Long-Term Exposure to Temperature Variability with Glucose Metabolism: Results from KORA F4 and FF4. Environmental Science And Technology 2025, 59: 24246-24256. PMID: 41200836, PMCID: PMC12631984, DOI: 10.1021/acs.est.5c04956.Peer-Reviewed Original ResearchConceptsKORA F4Homeostasis model assessmentQuantitative insulin sensitivity check indexAssociated with higher fasting insulinPopulation-based cohortExposure to temperature variabilityGlucose metabolismAssessment of B-cell functionGeneralized Estimating EquationsFasting insulinGlucose metabolism biomarkersGlobal diabetes epidemicHigher fasting insulinTemperature variabilityDiabetes prevalenceDiabetes epidemicLongitudinal associationsHealth remainsHOMA-IRFasting GlucoseModel assessment of insulin resistanceAssessment of insulin resistanceHomeostasis model assessment of insulin resistanceMetabolismInsulin sensitivity check indexLong-term exposure to traffic-related air pollution is associated with epigenetic age acceleration
Yao Y, Wolf K, Breitner S, Zhang S, Waldenberger M, Winkelmann J, Schneider A, Peters A. Long-term exposure to traffic-related air pollution is associated with epigenetic age acceleration. Environmental Research 2025, 288: 123284. PMID: 41202959, DOI: 10.1016/j.envres.2025.123284.Peer-Reviewed Original ResearchConceptsAnnual average concentrationsTraffic-related air pollutionExposure to traffic-related air pollutionLong-term exposure to traffic-related air pollutionAir pollutionParticulate matterEpigenetic ageing biomarkersAverage concentrations of ultrafine particlesLong-term exposure to air pollutionLand-use regression modelsExposure to air pollutionConcentrations of ultrafine particlesAir pollution exposureEpigenetic age accelerationAge accelerationPopulation-based Cooperative Health ResearchPollution exposureNegative impactEpigenome-wide association studiesPollutionCooperative Health ResearchRegion of AugsburgLinear mixed-effects regression modelsS4 surveyCoarse particlesShort-term exposure to low and high temperatures and mortality in heart failure patients: a nationwide study in Sweden
Ni W, Benson L, Ljungman P, Nobile F, Breitner S, Zhang S, Bont J, Lund L, Savarese G, Schneider A, Agewall S. Short-term exposure to low and high temperatures and mortality in heart failure patients: a nationwide study in Sweden. European Heart Journal 2025, 46 DOI: 10.1093/eurheartj/ehaf784.1081.Peer-Reviewed Original ResearchAll-CauseCardiovascular mortalityCause of Death RegisterRisk of all-causeHeart failure patientsNationwide studyAssociated with all-cause mortalityMortality risk curvesCase-crossover designConditional logistic regressionAll-Cause MortalityDeath RegisterMinimum mortality temperatureEffect modificationAir pollution levelsFailure patientsMedication useOdds ratioLogistic regressionMortality temperatureStatistical areasU-shaped patternHeart failureRisk curvesShort-term exposureThe Pressure Is Rising Emerging Environmental Determinants of Hypertension
Meng X, Rajagopalan S, Brook R, Zhang S, Chen K. The Pressure Is Rising Emerging Environmental Determinants of Hypertension. Journal Of The American College Of Cardiology 2025, 86: 1501-1503. PMID: 41162011, DOI: 10.1016/j.jacc.2025.08.070.Peer-Reviewed Original ResearchShort-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies
Li Y, Breitner-Busch S, Cascio W, Zhang S, Wolf K, Rückert-Eheberg I, Kääb S, Schmidt G, Strom A, Peters A, Schneider A. Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies. Particle And Fibre Toxicology 2025, 22: 26. PMID: 41107970, PMCID: PMC12534996, DOI: 10.1186/s12989-025-00645-6.Peer-Reviewed Original ResearchConceptsGeneralized Additive Mixed ModelsGeneralized additive modelAir pollutionShort-term effectsShort-term effects of air pollutionEffects of ambient PM2.5Effects of air pollutionBackgroundAmbient air pollutionAir quality standardsExposure to PM2.5Low pollution levelsAmbient air pollutionAir pollution dataAdditive mixed modelsShort-term associationsKORA S4Low ambient concentrationsKORA FF4Heart rate variabilityAmbient PM2.5Pollution levelsIQR increaseAmbient concentrationsPollution dataMonitoring stations
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