Sigrid Nachtergaele
Assistant Professor, Molecular, Cellular & Developmental BiologyCards
About
Research
Publications
2026
Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation
Fang D, Babich J, Stanton R, Vock I, Abdallah K, Zhu M, Letchuman R, Li R, Simon M, Gilbert W, Nachtergaele S. Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation. Nucleic Acids Research 2026, 54: gkag365. PMID: 42059200, PMCID: PMC13129541, DOI: 10.1093/nar/gkag365.Peer-Reviewed Original ResearchConceptsRibosome recruitmentCellular overexpressionSingle-stranded RNA regionsMessenger RNAMessenger RNA modificationHuman mRNA sequencesIn vitro methylationRegulation of messenger RNAsMitochondrial RNAMRNA sitesTranscriptome-wideConsensus motifRNA regionsSequence preferencesTRMT61BMethyltransferase activityMRNA sequencesSynthetic poolsM1A sitesRibosomeLuciferase reporterSequenceTranscriptionRNAEffect of m1A
2024
A user guide to RT-based mapping of RNA modifications
Fang D, Babich J, Dangelmaier E, Wall V, Nachtergaele S. A user guide to RT-based mapping of RNA modifications. Methods In Enzymology 2024, 705: 51-79. PMID: 39389673, DOI: 10.1016/bs.mie.2024.07.006.Peer-Reviewed Original ResearchCombating the myth of “innate genius” in science
Nachtergaele S. Combating the myth of “innate genius” in science. Cell Chemical Biology 2024, 31: 376-379. PMID: 38518742, DOI: 10.1016/j.chembiol.2024.02.005.Peer-Reviewed Original Research
2023
mRNA Regulation by RNA Modifications
Gilbert W, Nachtergaele S. mRNA Regulation by RNA Modifications. Annual Review Of Biochemistry 2023, 92: 175-198. PMID: 37018844, PMCID: PMC11192554, DOI: 10.1146/annurev-biochem-052521-035949.Peer-Reviewed Original Research