Razie Amraei, MD, PhD
Hospital ResidentCards
About
Research
Publications
2026
178 Correlation Between PTEN Protein Expression by Immunohistochemical Staining and PTEN DNA Alterations in Advanced Breast Carcinoma
Matar S, Amraei R, Kahn A, Walther Z, Finberg K, Gibson J, Rozenova K, Kahila M. 178 Correlation Between PTEN Protein Expression by Immunohistochemical Staining and PTEN DNA Alterations in Advanced Breast Carcinoma. Laboratory Investigation 2026, 106: 104457. DOI: 10.1016/j.labinv.2025.104457.Peer-Reviewed Original Research177 Characterization of Frequency and Spectrum of AKT1 and PTEN Alterations in Advanced Breast Cancer
Matar S, Amraei R, Kahn A, Walther Z, Finberg K, Gibson J, Rozenova K, Kahila M. 177 Characterization of Frequency and Spectrum of AKT1 and PTEN Alterations in Advanced Breast Cancer. Laboratory Investigation 2026, 106: 104456. DOI: 10.1016/j.labinv.2025.104456.Peer-Reviewed Original Research1597 Comparative Clinicopathologic and Survival Analysis of Lung Adenocarcinoma, LCNEC, and NSCLC with Neuroendocrine Features
Amraei R, Ragoowansi H, Walther Z, Kahila M, Woodard G, Dacic S. 1597 Comparative Clinicopathologic and Survival Analysis of Lung Adenocarcinoma, LCNEC, and NSCLC with Neuroendocrine Features. Laboratory Investigation 2026, 106: 105899. DOI: 10.1016/j.labinv.2025.105899.Peer-Reviewed Original Research
2025
STR genotyping diagnosis of hydatidiform moles: an assessment of 2871 consecutive products of conceptions
Amraei R, Niu N, Clark M, Ratner E, Buza N, Hui P. STR genotyping diagnosis of hydatidiform moles: an assessment of 2871 consecutive products of conceptions. Virchows Archiv 2025, 487: 1025-1034. PMID: 41076484, DOI: 10.1007/s00428-025-04282-4.Peer-Reviewed Original ResearchConceptsProducts of conceptionHydatidiform MoleTertiary care settingShort tandem repeat genotypingMolar gestationsPartial moleComplete moleClassification of hydatidiform molesDiagnosis of hydatidiform moleIncidence of hydatidiform moleNon-molar gestationsPartial Hydatidiform MoleAncillary diagnostic toolTandem repeat genotypingPatient ageStudy cohortTurnaround timeCare settingsAccurate diagnosisGestationRepeat genotypingSuccess rateDiagnostic toolLaser microdissectionConsultation casesCorrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]
Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror K, Farmer S, Wei W, Costello C, Chitalia V, Rahimi N. Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]. Molecular Metabolism 2025, 97: 102160. PMID: 40345243, PMCID: PMC12136701, DOI: 10.1016/j.molmet.2025.102160.Peer-Reviewed Original Research110 Characterization of Frequency and Spectrum of PIK3CA Somatic Mutations in Advanced Breast Cancer
Amraei R, Kahn A, Walther Z, Finberg K, Gibson J, Kahila M. 110 Characterization of Frequency and Spectrum of PIK3CA Somatic Mutations in Advanced Breast Cancer. Laboratory Investigation 2025, 105: 102334. DOI: 10.1016/j.labinv.2024.102334.Peer-Reviewed Original Research340 Cytomorphologic Challenges in Cervical Pap Tests of Transgender Men on Androgen Therapy: A Cyto-Histological Correlation Study
Haque M, Amraei R, Iyer K, Krishnamurti U, Adeniran A, Sun T. 340 Cytomorphologic Challenges in Cervical Pap Tests of Transgender Men on Androgen Therapy: A Cyto-Histological Correlation Study. Laboratory Investigation 2025, 105: 102567. DOI: 10.1016/j.labinv.2024.102567.Peer-Reviewed Original Research
2024
Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats
Amraei R, Lampl N, Nist K, Zhang Y, Wainford R. Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats. Physiological Genomics 2024, 57: 16-27. PMID: 39548828, DOI: 10.1152/physiolgenomics.00052.2024.Peer-Reviewed Original ResearchIncreased risk of HFRisk of HFMendelian randomizationMR analysisCardiovascular diseaseTwo-sample bidirectional Mendelian randomizationBidirectional MR analysisBidirectional Mendelian randomizationInstrumental variablesIncreased riskUnited Kingdom BiobankCoronary artery diseaseCausal effectsHorizontal pleiotropyPleiotropy testConfounding factorsHeart failureObservational studyGenetic variantsAtrial fibrillationPotential associationManagement of patientsEuropean populationsClinical management of patientsReverse causal effect
2023
Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity
Rahimi N, White M, Amraei R, Lotfollahzadeh S, Xia C, Michalak M, Costello C, Mühlberger E. Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity. Cells 2023, 12: 2694. PMID: 38067122, PMCID: PMC10705507, DOI: 10.3390/cells12232694.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectivityCardiovascular complicationsS-RBDSARS-CoV-2 infectionEndothelial cellsMajor clinical hallmarksSpike proteinCOVID-19 patientsCoronavirus disease 2019SARS-CoV-2 spike proteinSARS-CoV-2S proteinProteasomal inhibitor bortezomibHuman endothelial cellsShRNA-mediated knockdownCalcium hemostasisClinical hallmarkDisease 2019Inhibitor bortezomibCalcium homeostasisAcidification of lysosomesRole of calreticulinTreatment of cellsProtein levelsComplicationsInactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity
Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror K, Farmer S, Wei W, Costello C, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Molecular Metabolism 2023, 73: 101744. PMID: 37245847, PMCID: PMC10267597, DOI: 10.1016/j.molmet.2023.101744.Peer-Reviewed Original ResearchConceptsMTOR activationHigh-fat dietObesity-associated diseasesGlucose toleranceKO miceChronic diseasesPathophysiological roleBody fatMetabolic disordersHypertrophic adipocytesKnockout miceObesityAdipose tissuePhysiological negative regulatorType 2HEK-293 cellsImpaired expressionComplex disorderCell culture studiesAdipocytesDiseaseMiceDisordersMTORUnknown role