Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRobert Aaron Levine, MD
Clinical ProfessorAbout
Research
Publications
2025
Left Atrial Plication for Left Ventricular Posterior Wall Bending With Atrial Functional Mitral Regurgitation
Iwataki M, Oishi Y, Miki H, Onoue T, Nagata Y, Levine R, Otsuji Y, Nishimura Y, Kataoka M. Left Atrial Plication for Left Ventricular Posterior Wall Bending With Atrial Functional Mitral Regurgitation. JACC Case Reports 2025, 31: 106394. PMID: 41342815, PMCID: PMC12905679, DOI: 10.1016/j.jaccas.2025.106394.Peer-Reviewed Original ResearchAtrial functional mitral regurgitationFunctional mitral regurgitationGiant LAMitral regurgitationMV repairMitral valve (MV) surgeryLeft atriumLeft atrial plicationRheumatic mitral regurgitationLow cardiac outputGiant left atriumMV replacementChordal preservationPatient 2Patient 1Basal posterior wallPosterior wallCardiac outputPatientsPlicationRegurgitationRepairSurgeryO119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY.
Depauw N, Bijari F, Garonna A, Kang J, Chemli Y, Deng H, Dhaynaut M, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian M, Fakhri G, Levine R, Lehmann H, Chen Y, Jee K. O119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY. International Journal Of Particle Therapy 2025, 17: 100875. DOI: 10.1016/j.ijpt.2025.100875.Peer-Reviewed Original ResearchThe value of a novel three-dimensional mitral valve index in the assessment of the haemodynamic severity of rheumatic mitral stenosis
Giffoni R, Hung J, Neto J, de Sousa Pinto A, Gomes N, Pantaleão A, de Magalhães Esteves W, Dal-Bianco J, Tan T, Levine R, Nunes M. The value of a novel three-dimensional mitral valve index in the assessment of the haemodynamic severity of rheumatic mitral stenosis. Echo Research & Practice 2025, 12: 33. PMID: 41219791, PMCID: PMC12606853, DOI: 10.1186/s44156-025-00094-z.Peer-Reviewed Original ResearchMitral stenosisHaemodynamic severityRheumatic MSHaemodynamic burdenClinical presentationSeverity of rheumatic mitral stenosisPulmonary artery systolic pressureNet atrioventricular complianceArtery systolic pressureLeft atrial volumeRheumatic mitral stenosisClinical presentation of MSPresentation of MSTransmitral pressure gradientMitral valve geometryMean pressure gradientTenting heightTenting volumeAtrial volumeEchocardiographic assessmentValve anatomyAtrioventricular complianceMitral annulusMitral valveHaemodynamic consequencesGlobal prevalence and sex differences in rheumatic heart disease: a systematic review and updated meta-analysis
Mutarelli A, Pantaleao A, Melo P, Nogueira W, Nogueira A, Felix N, Generoso G, Cardoso R, Lupieri A, Aikawa E, Levine R, Nunes M. Global prevalence and sex differences in rheumatic heart disease: a systematic review and updated meta-analysis. Frontiers In Cardiovascular Medicine 2025, 12: 1615158. PMID: 41282342, PMCID: PMC12631635, DOI: 10.3389/fcvm.2025.1615158.Peer-Reviewed Original ResearchRheumatic heart diseaseRheumatic heart disease prevalenceAcute rheumatic feverGlobal prevalenceMeta-analysisPrevalence of rheumatic heart diseaseSequelae of acute rheumatic feverHeart diseaseLow-to-middle-income countriesAcquired cardiac diseaseCross-sectional studyWHF criteriaValve lesionsWHO criteriaFemale predominanceIndividuals aged 5Health systemSubgroup analysisRheumatic feverLow-income familiesCardiac diseaseRisk factorsSex disparitiesSystematic reviewEndemic regionsTCT-536 Percutaneous Transluminal Caval-flow Regulation PTCR®: An Emerging Innovation to Reduce Total Cardiac Burden in Heart Failure Patients, A Change of Paradigm in the Horizon
Herrera J, Herrera J, Finizola-Celli B, García E, Levine R, Palacios I. TCT-536 Percutaneous Transluminal Caval-flow Regulation PTCR®: An Emerging Innovation to Reduce Total Cardiac Burden in Heart Failure Patients, A Change of Paradigm in the Horizon. Journal Of The American College Of Cardiology 2025, 86: b235. DOI: 10.1016/j.jacc.2025.09.673.Peer-Reviewed Original ResearchAtrial Functional Mitral Regurgitation Small Volumes, Big Consequences
Levine R, Dal-Bianco J, Otsuji Y. Atrial Functional Mitral Regurgitation Small Volumes, Big Consequences. JACC Cardiovascular Imaging 2025, 18: 1297-1299. PMID: 41026077, DOI: 10.1016/j.jcmg.2025.08.018.Peer-Reviewed Original ResearchCollagen Fiber Maturity and Architecture in MVP-Associated Fibrosis Quantified by Digital Pathology
Phookan R, Morningstar J, Loizzi B, Van Kampen A, Gensemer C, Dieterlen M, Spampinato R, Petitjean L, Petitjean M, Petrucci T, Fenner R, Griner J, Byerly K, Levine R, Borger M, Norris R. Collagen Fiber Maturity and Architecture in MVP-Associated Fibrosis Quantified by Digital Pathology. Cells 2025, 14: 1536. PMID: 41090764, PMCID: PMC12523760, DOI: 10.3390/cells14191536.Peer-Reviewed Original ResearchConceptsMitral valve prolapseRegional myocardial fibrosisMyocardial fibrosisArrhythmogenic mitral valve prolapseHistopathological analysisAnalysis of endomyocardial biopsiesLife-threatening ventricular arrhythmiasPersistent fibrotic phenotypeMitral valve repairTime of surgeryRisk of arrhythmiaQuantitative image analysisLeaflet involvementEndomyocardial biopsyValve repairValve prolapseVentricular functionSurgical guidelinesVentricular arrhythmiasSubvalvular apparatusSurgical interventionMyocardial scarCollagen fiber maturationFibrotic phenotypeFibrosisA Large Animal Study of a Novel Cardiac-Ultrasound Image Guidance for Cardio-Respiratory-Gated Radiation Ablation to Ventricular Tachycardia Targets Using Proton Therapy
Chen Y, Bijari F, Deng H, Depauw N, Garonna A, Kang J, Kim H, Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G, Jee K, Chemli Y. A Large Animal Study of a Novel Cardiac-Ultrasound Image Guidance for Cardio-Respiratory-Gated Radiation Ablation to Ventricular Tachycardia Targets Using Proton Therapy. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: e632. DOI: 10.1016/j.ijrobp.2025.06.2930.Peer-Reviewed Original ResearchMembrane potential imagingRespiratory motionProton therapyDose drop-offDual gateExpert radiation oncologistsLayered repaintingScatter doseSafety of proton therapyAnimal studiesPotential imagesImaging biomarkersRadiation ablationMembrane potentialEffect of protonationSingle-gateImage guidance systemIACUC-approved protocolEarly effectsFunctional imaging biomarkersEarly radiation effectsNon-invasive optionOARsPTVGTVDeformable Image Registration for Assessing Time-Course Effect of Proton Beam in the Heart in the Presence of Large Anatomical Variations
Kim H, Bijari F, Kang J, Chemli Y, Depauw N, Garonna A, Moon S, Chen Y, Levine R, Lehmann H, Normandin M, Fakhri G, Bortfeld T, Jee K. Deformable Image Registration for Assessing Time-Course Effect of Proton Beam in the Heart in the Presence of Large Anatomical Variations. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: e57-e58. DOI: 10.1016/j.ijrobp.2025.06.3404.Peer-Reviewed Original ResearchDeformable image registrationDeformation vector fieldsDeformable image registration methodProton beam irradiationContour propagationDeformable image registration frameworkContrast-enhanced CT imagesPET-CT scanEffects of proton beamsEffective propagationBeam irradiationCardiac motion vector fieldImage registrationTime course effectsProton beamDIR methodsTime pointsLeft ventricleVector fieldsCT imagesResponse to therapyWeeks post-irradiationImage similarity metricsImaging time pointsInverse consistencyShort- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture
Clift C, Goudot G, Bogut G, Kasai T, van Kampen A, Negrao Pantaleao A, Messas E, Aikawa M, Singh S, Levine R, Pernot M, Aikawa E. Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture. Ultrasound In Medicine & Biology 2025, 51: 1936-1944. PMID: 40796501, DOI: 10.1016/j.ultrasmedbio.2025.06.026.Peer-Reviewed Original ResearchConceptsHuman valvular interstitial cellsAortic stenosisUltrasound therapyInterstitial cellsFirst-in-human studyAcute effectsTranscatheter aortic valve replacementLong-term effectsAortic valve replacementSevere aortic stenosisLeft ventricular hypertrophyValvular interstitial cellsCalcified aortic stenosisAortic valve diseaseEffects of ultrasound therapyProteomic profilingCalcific aortic valve diseaseOutflow tractSurgical repairValve replacementCardiac failureCalcification in vitroInvasive alternativeVentricular hypertrophySurgical intervention
Get In Touch
Contacts
Email