Felix Huo
Visiting Research ScientistDownloadHi-Res Photo
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2026
Elaidic acid suppresses hepatocellular carcinoma growth through modulating the production of intestinal Ligilactobacillus murinus-derived spermidine
Li Y, Tian T, Yu Q, Jiang H, Liu T, Wang H, Huo R, Gu C, Liu Y, Zhao Y, Zhang C, Zhou Y, Wang J, Ding L, Wang C, He X, Guo W, Yang W, Wang B. Elaidic acid suppresses hepatocellular carcinoma growth through modulating the production of intestinal Ligilactobacillus murinus-derived spermidine. International Journal Of Biological Sciences 2026, 22: 1542-1559. PMID: 41608620, PMCID: PMC12839069, DOI: 10.7150/ijbs.122392.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAnti-tumor effectsHepatocellular carcinomaHepatocellular carcinoma growthGut microbiotaFatty acid metabolomeAnalysis of 16S ribosomal RNA sequencesHCC growth inHepatocellular carcinoma patientsBcl-2-associated X proteinTumor protein 53Xenograft mouse modelRibosomal RNA sequencesPhosphorylation of p38 MAPKHepatocellular carcinoma treatmentCocktail of antibioticsHepatocellular carcinoma tumor growthTumor growthCarcinoma growthDietary interventionFatty acidsMouse modelCancer therapySequence analysisProtein 53RNA sequencingProcyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma
Huo R, Gu C, Liu Y, Wei Z, Liu T, Zhu J, Ding L, Liu Y, Wang C, Li Y, He X, Yang W, Wang B, Wei Y, Guo W. Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma. International Journal Of Biological Sciences 2026, 22: 161-177. PMID: 41362739, PMCID: PMC12681853, DOI: 10.7150/ijbs.113217.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD8+ T cellsMesenteric lymph nodesTumor microenvironmentB cellsHepatocellular carcinomaT cellsTumor volumeIFN-gTumor growthGut microbiotaMAPK pathwayB cell-T cell interactionsOrthotopic HCC mouse modelTherapeutic effectMortality of hepatocellular carcinomaHCC mouse modelAnti-tumor propertiesGut-liver axisHCC miceLymph nodesMulti-omics analysisHepatocellular carcinoma progressionSingle-cell RNA sequencingMouse modelGut-liver
2025
Selection and validation of a cell-internalizing DNA aptamer targeting esophageal squamous cell carcinoma.
Yang K, Xiao Z, Huo R, Cui Z, Huang S, Yu J, Wang J, Hong X, Dong M, Lan X, Liu K. Selection and validation of a cell-internalizing DNA aptamer targeting esophageal squamous cell carcinoma. Eur J Pharmacol 2025, 1008: 178372. PMID: 41241338, DOI: 10.1016/j.ejphar.2025.178372.Peer-Reviewed Original ResearchPlumbagin Triggers Cuproptosis in Hepatocellular Carcinoma (HCC) via the DNA‐Methyltransferase 1 (DNMT1)/microRNA‐302a‐3p (miR‐302a‐3p)/ATPase Copper Transporting Beta (ATP7B) Axis
Wang C, Wang H, Wang C, Tian T, Jin A, Liu Y, Huo R, Liu T, Pan B, Guo W, Yang W, Wang B. Plumbagin Triggers Cuproptosis in Hepatocellular Carcinoma (HCC) via the DNA‐Methyltransferase 1 (DNMT1)/microRNA‐302a‐3p (miR‐302a‐3p)/ATPase Copper Transporting Beta (ATP7B) Axis. MedComm 2025, 6: e70312. PMID: 40761482, PMCID: PMC12318818, DOI: 10.1002/mco2.70312.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMiR-302a-3pExpression of miR-302a-3pLuciferase reporter assayHepatocellular carcinomaDNA methyltransferase 1Natural biological moleculesReporter assayBiological moleculesTherapeutic strategiesAssociated with better prognosisCopper-dependent mechanismAnticancer activityMolecular phenotypesAccumulation of intracellular copperATPase copper transporting betaCancer drug developmentExpression levelsDNA methyltransferasesBetter prognosisHCC cellsTumor cellsProtein expression levelsPromoter hypomethylationCuproptosisClinical analysisBifidobacterium boosts anti-PD-1 effectiveness through JAK pathway in hepatocellular carcinoma.
Huo R, Xu QG, You YQ, Chen YL, Su GJ, Yang KR, Xiao YP, Xue Z, Li YJ, Sun P, Cui ZL, Lin YY, Guo JY, Xu HY, Chen ZS, Xie WT, Xu SH, Chen MY, Wu J, He SJ, Xiao ZZ, Chen Y. Bifidobacterium boosts anti-PD-1 effectiveness through JAK pathway in hepatocellular carcinoma. NPJ Precis Oncol 2025, 9: 251. PMID: 40702094, DOI: 10.1038/s41698-025-00960-3.Peer-Reviewed Original ResearchJuglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
Wang C, Zhao Y, Peng Y, Chen W, Zhu J, Gu C, Huo R, Ding L, Liu Y, Liu T, Zhang C, Yang W, Wang H, Guo W, Wang B. Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis. Phytomedicine 2025, 139: 156417. PMID: 39923427, DOI: 10.1016/j.phymed.2025.156417.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntineoplastic Agents, PhytogenicCarcinoma, HepatocellularCell Line, TumorCell MovementCell ProliferationFerroptosisHeme Oxygenase-1HumansLiver NeoplasmsMiceMice, Inbred BALB CMice, NudeNaphthoquinonesProto-Oncogene Proteins c-fosReactive Oxygen SpeciesXenograft Model Antitumor AssaysConceptsHepatocellular carcinomaIn vivo effectsPan-CancerEffects of jugloneManagement of hepatocellular carcinomaAnticancer effectsHepatocellular carcinoma xenograft mouse modelPotential inhibitory effectReactive oxygen speciesXenograft mouse modelCell deathHepatocellular carcinoma growthFerroptosis in vitroCell cycle distributionMode of programmed cell deathTCGA database analysisTumor cellsTumor growthDrug therapyLipid peroxidationBinding sitesMouse modelLevels of glutathioneFlow cytometryFerroptotic effects
2024
Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT
Sun Y, Li T, Ding L, Wang J, Chen C, Liu T, Liu Y, Li Q, Wang C, Huo R, Wang H, Tian T, Zhang C, Pan B, Zhou J, Fan J, Yang X, Yang W, Wang B, Guo W. Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT. Hepatology 2024, 81: 791-807. PMID: 38779918, DOI: 10.1097/hep.0000000000000934.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCirculating Tumor CellsNK cellsMultiplex immunofluorescenceAssociated with significantly shorter progression-free survivalCell killingShorter progression-free survivalTumor cell evasionProgression-free survivalNK cell cytotoxicityNK cell immunosurveillanceNK cell killingContact-dependent mannerMultiple cancer typesInnate immunosurveillanceImmunotherapeutic strategiesOverall survivalCell evasionDistant metastasisHematogenous disseminationTumor cellsSingle-cell RNA sequencingTumor metastasisCD155ImmunosurveillanceCancer cells
2023
Stigmasterol: Remodeling gut microbiota and suppressing tumor growth through Treg and CD8+ T cells in hepatocellular carcinoma
Huo R, Yang W, Liu Y, Liu T, Li T, Wang C, Pan B, Wang B, Guo W. Stigmasterol: Remodeling gut microbiota and suppressing tumor growth through Treg and CD8+ T cells in hepatocellular carcinoma. Phytomedicine 2023, 129: 155225. PMID: 38678948, DOI: 10.1016/j.phymed.2023.155225.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD8+ T cellsT cellsHepatocellular carcinomaTumor volumeTumor microenvironmentTumor cellsTumor tissuesRatio of regulatory T cellsIntratumoral immune cellsTreatment of hepatocellular carcinomaRegulatory T cellsCD8+ cellsDeath of tumor cellsOrally administered to BALB/c miceMalignant liver tumorsClinical applicationTumor growth in vivoCyclin D1 expressionAnti-tumor propertiesGut microbiotaGrowth in vivoTreg cellsRemodeling Gut MicrobiotaSorafenib treatmentIntestinal microbiotaAltered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma.
Huo R, Chen Y, Li J, Xu Q, Guo J, Xu H, You Y, Zheng C, Chen Y. Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma. Curr Oncol 2023, 30: 1818-1830. PMID: 36826102, DOI: 10.3390/curroncol30020141.Peer-Reviewed Original Research
2018
Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus.
Luo Y, Zeng B, Zeng L, Du X, Li B, Huo R, Liu L, Wang H, Dong M, Pan J, Zheng P, Zhou C, Wei H, Xie P. Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus. Transl Psychiatry 2018, 8: 187. PMID: 30194287, DOI: 10.1038/s41398-018-0240-5.Peer-Reviewed Original Research