Oluwabunmi Olaloye, MD, FAAP
Assistant ProfessorCards
About
Research
Publications
2026
The role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review
Devaris A, Blaise A, Konnikova L, Olaloye O. The role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review. Frontiers In Pediatrics 2026, 14: 1750294. PMID: 41837199, PMCID: PMC12982386, DOI: 10.3389/fped.2026.1750294.Peer-Reviewed Original ResearchNecrotizing enterocolitisMyeloid cellsPathogenesis of necrotizing enterocolitisPreterm infantsSevere gastrointestinal disordersImmune dysregulationIntestinal injuryAnimal studiesGastrointestinal disordersEnterocolitisMicrobiota imbalancePretermCellsNecrotizingMorbidityInfantsReviewPathogenesisMortalityInjuryScoping ReviewDysregulationImpact of the single cell revolution on neonatology research
St Denis K, Rice T, Olaloye O, Konnikova L. Impact of the single cell revolution on neonatology research. Current Opinion In Pediatrics 2026, 38: 177-183. PMID: 41700570, DOI: 10.1097/mop.0000000000001556.Peer-Reviewed Original ResearchConceptsSingle cell technologiesMulti-omics approachSingle-cell technologiesSingle cellsMulti-omics technologiesDisease activityNeonatal healthNeonatal developmentNeonatal researchImmune developmentAdult counterpartsDynamic regulationCellular heterogeneityMRNA transcriptsDiseaseTranslational discoveriesEarly-lifeCellsWealth of information
2025
Early-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape
Brodsky N, Chakder M, Kumar D, Barmada A, Wang J, Gu W, Olaloye O, Ramaswamy A, Wats A, Konnikova L, Lucas C. Early-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421106122. PMID: 40720649, PMCID: PMC12337316, DOI: 10.1073/pnas.2421106122.Peer-Reviewed Original ResearchConceptsCD8+ T cellsHuman CD8+ T cellsKiller cell lectin-like receptor G1Neonatal CD8+ T cellsT cellsTranscription factor landscapeIL-2Human CD8+ T cellsCD8+ T cellsDNAX accessory molecule-1Tumor necrosis factor-alphaT cell receptor activationInnate-like characteristicsNecrosis factor-alphaResponse to viral infectionTissue immunopathologyNeonatal humansEffector programIL-7Interleukin-2Factor-alphaThymocyte selectionViral illnessEffector responsesMolecule-1Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates
Balamurugan M, Ramatchandirin B, Desiraju S, Subrramanya A, Raj J, Ferris M, Lawal Z, Olaloye O, Konnikova L, MohanKumar K. Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates. Frontiers In Pediatrics 2025, 13: 1560242. PMID: 40746354, PMCID: PMC12310614, DOI: 10.3389/fped.2025.1560242.Peer-Reviewed Original ResearchNEC-like injuryPlatelet-monocyte aggregatesPlatelet-specific deletionMonocyte-platelet aggregatesMurine neonatesNecrotizing enterocolitisPlatelet-specific knockoutPlasma levelsSeverity of necrotizing enterocolitisPlatelet activation markersGastrointestinal diseasesIntestinal inflammatory responseTrinitrobenzene sulfonic acidPremature neonatesPlatelet-monocytePreclinical evidenceActivation markersIntegrin beta 3Injury markersMouse pupsIntestinal injuryInflammatory cytokinesIntestinal injury markersNeonatesPlatelet activationSpatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation
Velagala S, Phan L, Eke C, Fernandes A, Rice T, Olaloye O, Konnikova L. Spatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation. Mucosal Immunology 2025, 18: 848-860. PMID: 40288579, PMCID: PMC12560956, DOI: 10.1016/j.mucimm.2025.04.005.Peer-Reviewed Original ResearchVascular smooth muscle cellsPlacental villiSmooth muscle cellsMid-gestationMyeloid-derived suppressor cellsMuscle cellsMechanisms of preterm birthMaternal immune systemInnate lymphoid cellsRare T cellsFull-term samplesTolerogenic statePreterm birthSuppressor cellsImmune remodelingPregnancy complicationsDendritic cellsActivation markersT cellsImaging Mass CytometryLymphoid cellsImmune populationsMacrophage subtypesSyncytial trophoblastImmune systemA single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants
Olaloye O, Gu W, Gehlhaar A, Sabuwala B, Eke C, Li Y, Kehoe T, Farmer R, Gabernet G, Lucas C, Tsang J, Lakhani S, Taylor S, Tseng G, Kleinstein S, Konnikova L. A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants. Science Translational Medicine 2025, 17: eadr0942. PMID: 40043141, DOI: 10.1126/scitranslmed.adr0942.Peer-Reviewed Original ResearchConceptsExtremely premature infantsFull-term infantsT cellsMonths of lifePremature infantsImmune cellsMemory CD4+ T cellsCD4+ T cellsMemory-like T cellsAnalysis of immune cellsNaive CD4+Peripheral T cell developmentWeeks of gestationCord blood samplesNatural killer cellsT helper 1B cell receptor sequencesT cell developmentCycling T cellsMonths of ageSingle-cell suspensionsAmount of bloodSusceptibility to infectionCD4+Killer cells
2024
Comprehensive evaluation and practical guideline of gating methods for high-dimensional cytometry data: manual gating, unsupervised clustering, and auto-gating
Liu P, Pan Y, Chang H, Wang W, Fang Y, Xue X, Zou J, Toothaker J, Olaloye O, Santiago E, McCourt B, Mitsialis V, Presicce P, Kallapur S, Snapper S, Liu J, Tseng G, Konnikova L, Liu S. Comprehensive evaluation and practical guideline of gating methods for high-dimensional cytometry data: manual gating, unsupervised clustering, and auto-gating. Briefings In Bioinformatics 2024, 26: bbae633. PMID: 39656848, PMCID: PMC11630031, DOI: 10.1093/bib/bbae633.Peer-Reviewed Original ResearchPlacenta and Intestinal Injury in Preterm Infants
Garg P, Weitkamp J, McDonald A, Cilvik S, Mir I, Shenberger J, Olaloye O, Konnikova L, Kallapur S, Garg P. Placenta and Intestinal Injury in Preterm Infants. American Journal Of Perinatology 2024, 42: 415-419. PMID: 38889889, PMCID: PMC11724007, DOI: 10.1055/a-2347-4135.Peer-Reviewed Original ResearchNecrotizing enterocolitisIntestinal injuryRisk factors associated with necrotizing enterocolitisDevelopment of necrotizing enterocolitisLow birth weight infantsAssociated with intestinal injuryExposure to inflammationProspective multi-center studyAt-risk infantsHuman clinical studiesMulti-center studyPreterm infantsPlacental pathologyPreterm birthImmunomodulatory treatmentIntrauterine environmentLaboratory predictorsCause of deathClinical outcomesClinical impactClinical studiesPostnatal lifeVulnerable infantsPost pregnancyTriggering inflammationSingle-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells
Gu W, Eke C, Santiago E, Olaloye O, Konnikova L. Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells. Mucosal Immunology 2024, 17: 599-617. PMID: 38555026, PMCID: PMC11384551, DOI: 10.1016/j.mucimm.2024.03.011.Peer-Reviewed Original ResearchImmune cellsDevelopment of mucosal immunityComplex immune landscapeFetal immune cellsSevere intestinal complicationsComplications of prematurityMemory T cellsAdaptive immune cellsMucosal immune cellsSmall intestineT cell statesMemory T cell statesStem-like propertiesNecrotizing enterocolitisNeonatal samplesMyeloid populationsImmune landscapeFetal samplesT cellsExpression of activationPostnatal samplesMucosal diseaseMucosal immunitySingle-cell RNA sequencingSingle-cell atlas
2023
Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis
Egozi A, Olaloye O, Werner L, Silva T, McCourt B, Pierce R, An X, Wang F, Chen K, Pober J, Shouval D, Itzkovitz S, Konnikova L. Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis. PLOS Biology 2023, 21: e3002124. PMID: 37205711, PMCID: PMC10234541, DOI: 10.1371/journal.pbio.3002124.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingSingle-cell atlasEpithelial cellsCell identityRNA sequencingBulk transcriptomicsCellular dysregulationAberrant interactionsNeonatal small intestinePotential targetCellular changesBiomarker discoveryGastrointestinal complicationsPremature infantsProinflammatory macrophagesProinflammatory genesClonal expansionT cellsEndothelial cellsImmune interactionsIntestinal tissueCellsSmall intestineComprehensive viewNEC
News
News
- March 25, 2026
Find Panelists, Workshops, and Presenters from Yale Pediatrics at the 2026 Pediatric Academic Societies (PAS) Meeting
- February 19, 2026Source: The Incubator Podcast
Navigating the Neonatal Immune Landscape: Insights from Dr. Bunmi Olaloye
- February 28, 2025
Yale Pediatrics Poster Presenters at PAS 2025
- November 21, 2024
Prematurity Awareness Month: Researching the Pre-term Immune System
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New Haven, CT 06519
Events
May 202629Friday
Everyone Maria Carmen Collado, PhD - Omry Koren, PhD - Oluwabunmi Olaloye, MD, FAAP - Mandy Brown Belfort, MD, MPH