Lingfeng Qin
Senior Research ScientistCards
About
Research
Publications
2026
Clinical Characteristics of Hospitalized Patients with Abdominal Aortic Aneurysm: A Large Retrospective Study in China
Xin S, Jiang B, Li X, Wang L, Wang D, Li T, Qin L, Zhang W. Clinical Characteristics of Hospitalized Patients with Abdominal Aortic Aneurysm: A Large Retrospective Study in China. Annals Of Vascular Surgery 2026, 128: 37-44. PMID: 41692163, DOI: 10.1016/j.avsg.2026.01.041.Peer-Reviewed Original ResearchAAA patientsFemale patientsClinical characteristicsAccurate disease burden estimatesClinical characteristics of hospitalized patientsLife-threatening cardiovascular disordersProportion of female patientsAge of male patientsAbdominal aortic aneurysm (AAAYoung female patientCharacteristics of hospitalized patientsAbdominal aortic aneurysmMale patientsRetrospective studyYounger patientsAortic aneurysmDietary patternsAge distributionDisease burden estimatesSex distributionHospitalized patientsPatientsCardiovascular disordersMetabolic disordersExposure to cold environmentsA fibroblast-like endothelial cell state promotes atherosclerosis via C/EBPβ-activated TGF-β signaling
Fan L, Zhu Y, Li Y, Ji Z, Ma K, Zhang Y, Wei L, Chen J, Jiang Y, Lai D, Qin L, Fu G, Simons M, Xu L, Yu L, Qiu C. A fibroblast-like endothelial cell state promotes atherosclerosis via C/EBPβ-activated TGF-β signaling. The EMBO Journal 2026, 45: 1077-1108. PMID: 41495247, PMCID: PMC12910015, DOI: 10.1038/s44318-025-00684-x.Peer-Reviewed Original ResearchConceptsTGF-b signalingMolecular detailsRegulation of downstream genesExtracellular matrixMolecular signaturesPhenotypic plasticityTranscriptional landscapeTranscription factorsDownstream genesRNA sequencingCell statesPseudotime trajectory analysisEndothelial cell stateEndothelial cellsPhenotypic transitionC/EBPBAtherosclerotic blood vesselsPhenotypeIn vivoIn vitroReceptor type IRegulationEC populationsSignalTranscription
2025
Author Correction: Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
Zhou H, Qin L, Jiang Q, Murray K, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, Min W. Author Correction: Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nature Communications 2025, 16: 6352. PMID: 40640167, PMCID: PMC12246070, DOI: 10.1038/s41467-025-61617-0.Peer-Reviewed Original ResearchAuthor Correction: SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression
Shao L, Zhou H, Zhang H, Qin L, Hwa J, Yun Z, Ji W, Min W. Author Correction: SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nature Communications 2025, 16: 5366. PMID: 40550826, PMCID: PMC12185721, DOI: 10.1038/s41467-025-60998-6.Peer-Reviewed Original ResearchCorrection to: mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis
Min W, Qin L, Zhang H, López-Giráldez F, Jiang N, Kim Y, Mohan V, Su M, Murray K, Grutzendler J, Zhou J. Correction to: mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis. Circulation Research 2025, 137: e16-e17. PMID: 40536942, DOI: 10.1161/res.0000000000000718.Peer-Reviewed Original ResearchCEBPB drives a novel endothelial pathological phenotype and promotes atherosclerosis by directly upregulating TGFBR1 expression
Qiu C, Fan L, Zhu Y, Ma K, Wei L, Chen J, Jiang Y, Lai D, Qin L, Fu G, Simons M, Yu L. CEBPB drives a novel endothelial pathological phenotype and promotes atherosclerosis by directly upregulating TGFBR1 expression. Physiology 2025, 40: 1003. DOI: 10.1152/physiol.2025.40.s1.1003.Peer-Reviewed Original ResearchSingle-cell RNA sequencingPathological phenotypesTranscription factorsRNA sequencingTranscriptional profilesPromotor regionAortic endothelial cellsRegulation of downstream genesNational Key Research and Development ProgramVascular inflammationHuman aortic endothelial cellsEndothelial cellsMolecular signaturesEndothelial markersTGF-b signalingRegulation in vitroNational Natural Science FoundationRegulatory networksNovel regulatorsTranscriptional landscapeFibroblast markersDownstream genesAdeno-associated virusCultured human aortic endothelial cellsGene expressionShort-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection
Jiang B, Ren P, He C, Wang M, Murtada S, Ruiz-Rodríguez M, Chen Y, Ramachandra A, Li G, Qin L, Assi R, Schwartz M, Humphrey J, Tellides G. Short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection. JCI Insight 2025, 10 PMID: 39932797, PMCID: PMC11949005, DOI: 10.1172/jci.insight.182629.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsBlood pressureAortic dissectionAdult miceInherited connective tissue disorderConnective tissue disordersTGF-b signalingAccumulation of bloodHigh blood pressureAortic phenotypeTissue disordersMolecule expressionTGFB signalingMuscle cellsRisk factorsSynthesis of extracellular matrixSustained increaseTransient increaseBlood extravasationDissectionMedial injuryExtracellular matrix productionVascular degenerationExperimental modelMice
2024
Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering
Batty L, Park J, Qin L, Riaz M, Lin Y, Xu Z, Gao X, Li X, Lopez C, Zhang W, Hoareau M, Fallon M, Huang Y, Luo H, Luo J, Ménoret S, Li P, Jiang Z, Smith P, Sachs D, Tellides G, Anegon I, Pober J, Liu P, Qyang Y. Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering. Acta Biomaterialia 2024, 193: 171-184. PMID: 39681154, PMCID: PMC12212065, DOI: 10.1016/j.actbio.2024.12.033.Peer-Reviewed Original ResearchInduced pluripotent stem cellsVascular tissue engineeringPig induced pluripotent stem cellsPluripotent stem cellsEndothelial cellsLarge animal modelStem cellsAnimal modelsTissue engineeringInferior vena cava graftHuman induced pluripotent stem cellsEffective differentiation protocolsPreclinical large animal modelExpression of endothelial markersCell-based therapiesExtensive preclinical testingPig endothelial cellsFunctional endothelial cellsIn vivo functional studiesTreatment of cardiovascular diseasesVascular endothelial cellsTissue engineering therapiesTransplant therapeuticsEfficacy of tissueImmunodeficient ratsmTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis
Min W, Qin L, Zhang H, López-Giráldez F, Jiang N, Kim Y, Mohan V, Su M, Murray K, Grutzendler J, Zhou J. mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis. Circulation Research 2024, 135: e94-e113. PMID: 38957991, PMCID: PMC11293987, DOI: 10.1161/circresaha.123.324015.Peer-Reviewed Original ResearchCerebral vascular malformationsEndothelial progenitor cellsBlood-brain barrier integritySingle-cell RNA sequencing analysisDisruption of blood-brain barrier integrityBarrier integrityResident endothelial progenitor cellsRNA sequencing analysisTissue immunofluorescence analysisEndothelial cellsEPC clustersStem cell markersFocal neurological deficitsBrain's neurovascular unitMTOR signalingHuman CCM lesionsMTORC1 signalingBlood-brain barrierCapillary endothelial cellsCCM pathogenesisVascular malformationsLesion signaturesNeurological deficitsCell markersClonal expansionSUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis
Ren R, Ding S, Ma K, Jiang Y, Wang Y, Chen J, Wang Y, Kou Y, Fan X, Zhu X, Qin L, Qiu C, Simons M, Wei X, Yu L. SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis. Circulation Research 2024, 134: 203-222. PMID: 38166414, PMCID: PMC10872267, DOI: 10.1161/circresaha.123.323398.Peer-Reviewed Original ResearchDNA-binding capabilityElectrophoretic mobility shift assaysEndothelial cell-specific expressionMobility shift assaysHairy/EnhancerCell-specific expressionPrimary human endothelial cellsNotch pathway componentsE-box promoter elementsEndothelial cellsRegulation of angiogenesisHelix familyPostnatal vascular growthHey1 functionsTranscriptional complexChromatin immunoprecipitationE3 ligaseRTK signalingEmbryonic developmentMatrigel plug assayPromoter elementsBioinformatics analysisShift assaysSUMOylationDNA binding