Kevin B. Givechian, PhD
About
Research
Publications
2025
ImmunoStruct enables multimodal deep learning for immunogenicity prediction
Givechian KB, Rocha JF, Liu C, Yang E, Tyagi S, Greene K, Ying R, Caron E, Iwasaki A, Krishnaswamy S. ImmunoStruct enables multimodal deep learning for immunogenicity prediction. Nature Machine Intelligence 2025, 8 DOI: 10.1038/s42256-025-01163-y.Peer-Reviewed Original ResearchImmunoStruct enables multimodal deep learning for immunogenicity prediction
Givechian K, Rocha J, Liu C, Yang E, Tyagi S, Greene K, Ying R, Caron E, Iwasaki A, Krishnaswamy S. ImmunoStruct enables multimodal deep learning for immunogenicity prediction. Nature Machine Intelligence 2025, 8: 70-83. DOI: 10.1038/s42256-025-01163-y.Peer-Reviewed Original ResearchTranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis
Fijany A, Holan C, Troia T, Montorfano L, Mubang R, Givechian K, Karagoz H, Martinez-Jorge J, Perdikis G, Connor L, Slater E. Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis. Aesthetic Surgery Journal 2025, 45: 1026-1034. PMID: 40509914, PMCID: PMC12550359, DOI: 10.1093/asj/sjaf112.Peer-Reviewed Original ResearchBody Contouring ProceduresWound healing complicationsTranexamic acidTXA administrationContouring proceduresTopical TXA administrationHealing complicationsMeta-analysisImpact of tranexamic acidOdds ratioTranexamic acid cohortRisk of hematomaWound healing issuesDecreased risk of infectionBody contouring surgeryConfidence intervalsRandom-effects modelRisk of infectionBreast reconstructionAntifibrinolytic drugsSeroma formationContouring surgerySubgroup analysisHealing issuesDecreased risk
2024
Success of Bone Ossification After Posterior Vault Distraction Osteogenesis in Patients With Craniosynostosis
Sayadi J, Lujan-Hernandez J, Givechian K, Mackay D, Lorenz H, Grant G, Mahaney K, Hong D, Khosla R. Success of Bone Ossification After Posterior Vault Distraction Osteogenesis in Patients With Craniosynostosis. Journal Of Craniofacial Surgery 2024, 36: 870-875. PMID: 39819807, DOI: 10.1097/scs.0000000000010844.Peer-Reviewed Original ResearchPosterior vault distraction osteogenesisDistraction osteogenesisTitanium mesh cranioplastyTime of surgeryComputed tomography scanAssociated with ageMesh cranioplastySyndromic craniosynostosisTomography scanDefinitive reconstructionOlder patientsEffective treatmentPatientsStudy populationOperative detailsLatency periodIncreasing ageDistraction areaComplete ossificationDistraction siteCranial defectsDegree of ossificationCraniosynostosisOssificationBone ossification
2023
Complication Profiles of Smooth vs Textured Tissue Expanders in Breast Reconstruction: A Systematic Review and Meta-Analysis
Fijany A, Chaker S, Hung Y, Zago I, Friedlich N, Olsson S, Holan C, Montorfano L, Mubang R, Givechian K, Boctor M, Pekarev M, Martinez-Jorge J, Slater E. Complication Profiles of Smooth vs Textured Tissue Expanders in Breast Reconstruction: A Systematic Review and Meta-Analysis. Aesthetic Surgery Journal 2023, 44: 383-393. PMID: 37757895, DOI: 10.1093/asj/sjad319.Peer-Reviewed Original ResearchBIA-ALCLTissue expanderComplication profileSurgical outcomesBreast implantsSystematic reviewTissue expansionAnaplastic large cell lymphomaSimilar complication profileLarge cell lymphomaTimes higher oddsRandom-effects modelEarly complicationsHodgkin's lymphomaMean durationBreast reconstructionInclusion criteriaCell lymphomaHigher oddsMeta-analysisMean timeExplantationTTEComplicationsFurther studiesTranexamic acid in burn surgery: A systematic review and meta-analysis
Fijany A, Givechian K, Zago I, Olsson S, Boctor M, Gandhi R, Pekarev M. Tranexamic acid in burn surgery: A systematic review and meta-analysis. Burns 2023, 49: 1249-1259. PMID: 37268542, DOI: 10.1016/j.burns.2023.05.009.Peer-Reviewed Original ResearchConceptsTotal body surface areaBlood lossTranexamic acidBurn surgerySystematic reviewVenous thromboembolism eventsSurgical blood lossNumber of patientsBody surface areaRandom-effects modelBlood cell concentrationAggressive resuscitationThromboembolism eventsVTE eventsSignificant bleedingPharmacologic interventionsSurgery outcomesEarly excisionSevere burnsControl groupSignificant fluid lossSurgeryTransfusionInjuryMortality
2022
Transformer-based protein generation with regularized latent space optimization
Castro E, Godavarthi A, Rubinfien J, Givechian K, Bhaskar D, Krishnaswamy S. Transformer-based protein generation with regularized latent space optimization. Nature Machine Intelligence 2022, 4: 840-851. DOI: 10.1038/s42256-022-00532-1.Peer-Reviewed Original ResearchMultimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma
Leitner BP, Givechian KB, Ospanova S, Beisenbayeva A, Politi K, Perry RJ. Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma. Npj Precision Oncology 2022, 6: 8. PMID: 35087143, PMCID: PMC8795406, DOI: 10.1038/s41698-021-00248-2.Peer-Reviewed Original ResearchNon-small cell lung cancerLung squamous cell carcinomaBody mass indexSquamous cell carcinomaLung adenocarcinomaHigher glucose uptakeVisceral adiposityVisceral fatCell carcinomaLung cancerGlucose uptakeTreatment of NSCLCHigher Body Mass IndexTumor-infiltrating T cellsImmune checkpoint inhibitionCell lung cancerHigh visceral fatPET/CT imagingTumors of patientsPrecision therapy approachesTumor glucose uptakePrecision medicine approachLUSC tumorsPrognostic gene expressionAdjunct therapy
2020
Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression
Givechian K, Garner C, Benz S, Rabizadeh S, Soon-Shiong P. Glycolytic expression in lower-grade glioma reveals an epigenetic association between IDH mutation status and PDL1/2 expression. Neuro-Oncology Advances 2020, 3: vdaa162. PMID: 33532725, PMCID: PMC7837356, DOI: 10.1093/noajnl/vdaa162.Peer-Reviewed Original ResearchChIP-seq dataEpigenetic linkR132H/Promoter methylationPromoter methylation patternsPromoter H3K4me3Cancer Genome AtlasGenomic analysisDNA methylationRNA-seqImmortalized human astrocytesMethylation patternsMethylation dataEpigenetic associationsCheckpoint genesCell line dataMethylation levelsMethylationWild-type IDHHuman low-grade gliomasGenome AtlasExpression levelsExpression ratioGlycolysisGenes
2019
Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity
Wnuk K, Sudol J, Givechian K, Soon-Shiong P, Rabizadeh S, Szeto C, Vaske C. Deep Learning Implicitly Handles Tissue Specific Phenomena to Predict Tumor DNA Accessibility and Immune Activity. IScience 2019, 20: 119-136. PMID: 31563852, PMCID: PMC6823659, DOI: 10.1016/j.isci.2019.09.018.Peer-Reviewed Original ResearchDNA accessibilityChromatin stateOpen chromatin stateChromatin regulationSpecific tissue typesPromoter-flanking regionAccessibility landscapeCancer Genome AtlasTranscriptional eventsTissue-specific phenomenonDNA sequencesGenome AtlasTissue typesImmune pathwaysPromoterTumor progressionAccessibility patternsLung adenocarcinomaNew toolKey dynamic featuresTumor typesPathwayRegulationImmune activitySequence