Karen Le, PhD
Assistant Professor of NeurologyCards
About
Research
Publications
2026
Melodic intonation therapy paired with video feedback: A potential method for bolstering production?
Lindsey A, Fleck C, Atienza D, Sabella L, Kletzel S, Lê K. Melodic intonation therapy paired with video feedback: A potential method for bolstering production? Clinical Linguistics & Phonetics 2026, ahead-of-print: 1-21. PMID: 41961111, DOI: 10.1080/02699206.2026.2651140.Peer-Reviewed Original ResearchMelodic Intonation TherapyNon-fluent aphasiaVideo feedbackLanguage productionChronic non-fluent aphasiaApraxia of speechSpeech-language interventionWord retrievalPrefrontal cortexSpeech fluencyInsular cortexTreatment componentsBehavioral interventionsTreatment outcomesAphasiaParticipants' useTreatment sessionsAssessment periodCortexSessionsSpeechTraining elementsParticipantsClinical utilityLanguage
2025
Differences in narrative discourse ability in traumatic brain injury and a neurotypical comparison group: Influence of age, education, and sex
Lê K, Lindsey A, Coelho C, Fiszdon J, Feinn R. Differences in narrative discourse ability in traumatic brain injury and a neurotypical comparison group: Influence of age, education, and sex. Archives Of Physical Medicine And Rehabilitation 2025 PMID: 41038423, PMCID: PMC12723613, DOI: 10.1016/j.apmr.2025.09.015.Peer-Reviewed Original ResearchNon-brain-injuredTraumatic brain injuryTraumatic brain injury groupDiscourse measuresDiscourse comprehensionDiscourse outcomesAnalysis of covarianceNon-brain-injured groupDiscourse Comprehension TestNarrative discourse abilitiesNeurotypical comparison groupInfluence of traumatic brain injuryBrain injuryMild-moderate cognitive impairmentUnivariate analysis of covarianceDiscourse abilitiesDiscourse performanceNarrative comprehensionStory comprehensionStory grammarStory completionCognitive impairmentEffect sizeComparison groupInfluence of sociodemographic factors
2024
Narrative Discourse Performance in Traumatic Brain Injury: Does Story Comprehension Predict Story Retelling?
Lê K, Coelho C, Feinn R. Narrative Discourse Performance in Traumatic Brain Injury: Does Story Comprehension Predict Story Retelling? Journal Of Speech Language And Hearing Research 2024, 67: 2685-2697. PMID: 39052432, PMCID: PMC11305611, DOI: 10.1044/2024_jslhr-23-00681.Peer-Reviewed Original ResearchConceptsStructure Building FrameworkTraumatic brain injuryDiscourse comprehensionDiscourse Comprehension TestStory comprehension taskStory retelling taskComprehensive measureBrain injuryModerate-to-large correlationsDiscourse measuresDiscourse performanceRetelling taskStory comprehensionStory retellingComprehension taskDiscourse productionPreliminary supportDiscourse interventionCognitive processesStory grammarStory completionGrammar performanceSpoken languageMultiple regression analysisDiscourse model
2023
Contribution of Working Memory and Inferencing to Narrative Discourse Comprehension and Production in Traumatic Brain Injury.
Lê K, Coelho C, Feinn R. Contribution of Working Memory and Inferencing to Narrative Discourse Comprehension and Production in Traumatic Brain Injury. Journal Of Speech Language And Hearing Research 2023, 66: 2346-2361. PMID: 37257416, PMCID: PMC10468118, DOI: 10.1044/2023_jslhr-22-00632.Peer-Reviewed Original ResearchConceptsDiscourse Comprehension TestStructure Building FrameworkContribution of working memoryTraumatic brain injuryDiscourse comprehensionWM measuresDiscourse abilitiesNarrative discourse abilitiesBrain injuryWM updatingPredictive inferencingCognitive substratesWorking memoryStory comprehensionStory retellingDiscourse outcomesCognitive processesStory completionComprehensive processNarrative performanceDiscourse modelDCT performanceWMComprehensionComprehension testDiscourse Characteristics in Traumatic Brain Injury
Lê K, Coelho C. Discourse Characteristics in Traumatic Brain Injury. 2023, 65-80. DOI: 10.1007/978-3-031-45190-4_5.Peer-Reviewed Original ResearchPost-traumatic stress disorderTraumatic brain injuryMental healthBrain injuryDiscourse deficitsMajor life domainsDiscourse impairmentDiscourse comprehensionStress disorderCognitive underpinningsMH symptomsLife domainsDiscourse modelDiscourse characteristicsDiscourse functionsFunctional impactWritten discourseDeficitsTraumatizationVeteransDisordersImpairmentComprehensionUnderpinningsSymptoms
2022
Systematic Review of Discourse and Social Communication Interventions in Traumatic Brain Injury.
Lê K, Coelho C, Fiszdon J. Systematic Review of Discourse and Social Communication Interventions in Traumatic Brain Injury. American Journal Of Speech-Language Pathology 2022, 31: 991-1022. PMID: 35226552, PMCID: PMC11307254, DOI: 10.1044/2021_ajslp-21-00088.Peer-Reviewed Original Research
2021
Traumatic Brain Injury
Lê K, Mozeiko J. Traumatic Brain Injury. 2021, 590-612. DOI: 10.1002/9781119606987.ch25.Peer-Reviewed Original ResearchCognitive-communication disordersTraumatic brain injuryMonologic discourseManagement of cognitive-communication disordersConversational discourseAnalysis of conversational discourseBrain injuryAreas of attentionSuper structural levelPragmatic deficitsExecutive functionCommunication deficitsLanguage functionNonverbal behaviorLinguistic unitsCognitive interpretationResponse appropriatenessCommunication abilityDiscourseInformation processingTopical managementDeficitsSocial reintegrationDisordersPervasive nature
2014
Does Brain Volume Loss Predict Cognitive and Narrative Discourse Performance Following Traumatic Brain Injury?
Lê K, Coelho C, Mozeiko J, Krueger F, Grafman J. Does Brain Volume Loss Predict Cognitive and Narrative Discourse Performance Following Traumatic Brain Injury? American Journal Of Speech-Language Pathology 2014, 23: s271-s284. PMID: 24686463, DOI: 10.1044/2014_ajslp-13-0095.Peer-Reviewed Original ResearchConceptsNarrative discourse measuresDiscourse measuresCognitive measuresBrain volume lossDiscourse outcomesSmall-to-moderate correlationsDiscourse production taskNarrative discourse abilitiesMeasures of brain damageGeneral cognitive statusHemispheric volume lossTraumatic brain injuryWorking memoryDiscourse abilitiesExecutive functionDiscourse performanceImmediate memoryVolume lossBrain regionsProduction taskLesion metricsCognitive statusBrain damageBrain injuryAtrophy measures
2013
Characterizing Discourse Deficits Following Penetrating Head Injury: A Preliminary Model
Coelho C, Lê K, Mozeiko J, Hamilton M, Tyler E, Krueger F, Grafman J. Characterizing Discourse Deficits Following Penetrating Head Injury: A Preliminary Model. American Journal Of Speech-Language Pathology 2013, 22: s438-s448. PMID: 23695915, PMCID: PMC7684633, DOI: 10.1044/1058-0360(2013/12-0076).Peer-Reviewed Original ResearchConceptsNon-brain-injuredClosed head injuryDiscourse productionDiscourse performanceNon-brain-injured groupAdequate-to-good fitMeasures of memoryPenetrating Head InjuryStructural equation modeling proceduresGroups of participantsTraumatic brain injuryDiscourse deficitsDiscourse measuresExecutive functionNarrative lengthCommunication deficitsMacrostructural componentsHead injuryStory grammarBrain-injuredStory narrativesBrain injuryGroup of individualsDeficitsDiscourse data
2012
Discourse production following injury to the dorsolateral prefrontal cortex
Coelho C, Lê K, Mozeiko J, Krueger F, Grafman J. Discourse production following injury to the dorsolateral prefrontal cortex. Neuropsychologia 2012, 50: 3564-3572. PMID: 22982512, DOI: 10.1016/j.neuropsychologia.2012.09.005.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexPrefrontal cortexDorsolateral prefrontal cortex lesionsMeasures of working memoryComparison groupYears post-onsetDLPFC groupNon-injured comparison groupLanguage of individualsDiscourse analysis procedurePFC lesionsLanguage impairmentDiscourse impairmentDiscourse abilitiesDiscourse performanceDiscourse productionNarrative coherenceRight (RComplex languageCortexImpairmentDiscourse analysisDiscourseIndividualsAphasia