David Frankfurter, MD
he/him/his
Professor of Obstetrics, Gynecology and Reproductive SciencesCards
About
Research
Publications
2023
Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42
Seifer D, Wang S, Frankfurter D. Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42. Reproductive Biology And Endocrinology 2023, 21: 94. PMID: 37872609, PMCID: PMC10591412, DOI: 10.1186/s12958-023-01144-z.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateART cyclesBirth rateDesignRetrospective cohort studyPrior ART cyclesUse of ICSIEtiology of infertilityNumber of oocytesAge categoriesSART CORS databaseYears of ageTreatment cycle numberRace/ethnicityAutologous cyclesResultsBetween 2014Ovarian reserveCohort studyBlastocyst transferWomen 46Women 42Age 45Live birthsMAIN OUTCOMEPhysician expectationsProgress on the Endometrium
Frankfurter D, Kliman H. Progress on the Endometrium. Obstetrics And Gynecology Clinics Of North America 2023, 50: 677-694. PMID: 37914487, DOI: 10.1016/j.ogc.2023.09.002.Peer-Reviewed Original ResearchConceptsAbsence of pregnancyEvidence-based approachEndometrial assessmentStromal maturationEndometrial proliferationEndometrial pathologyInflammatory mediatorsOvarian steroidsImplantation failureBlastocyst implantationEndometrial sloughingDiagnostic measuresEndometriumOffer hopeDynamic tissueDevelopmental markersSingle testTissueInternal reproductionMaturationEndometriosisPregnancyDecidualizationInfertilityUterus
2021
The road to validating preimplantation genetic testing for aneuploidy; are we there yet?
Humm K, Frankfurter D. The road to validating preimplantation genetic testing for aneuploidy; are we there yet? Fertility And Sterility 2021, 115: 585-586. PMID: 33558020, DOI: 10.1016/j.fertnstert.2020.12.029.Peer-Reviewed Original ResearchWell-being in trainee and faculty physicians
Frishman G, Raker C, Frankfurter D. Well-being in trainee and faculty physicians. Medical Education Online 2021, 26: 1950107. PMID: 34252014, PMCID: PMC8276666, DOI: 10.1080/10872981.2021.1950107.Peer-Reviewed Original ResearchConceptsObstetrics and GynecologySubspecialty fellowsCross-sectional studyOB/GYN residentsGynecology traineesProgression of trainingDuty hoursPost-graduate traineesOB/GYNU.S. traineesNo differenceGynecologyObstetricsCore facultySubspecialty facultyFaculty physiciansPhysician traineesAssessed differencesSubspecialtyImpacted traineesPhysiciansPhysician well-beingHoursProgressionIntervention
2020
Association of Urinary THC Concentrations and Sperm Abnormalities in US Urban Men
McLeland-Wieser H, Young H, Neumann L, Crites J, Moody D, Irwig M, Frankfurter D, Perry M. Association of Urinary THC Concentrations and Sperm Abnormalities in US Urban Men. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1117.Peer-Reviewed Original ResearchThe Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC
McCray N, Young H, Irwig M, Frankfurter D, Schwartz A, Witmyer J, Hynes M, Jayanthi V, Marcus M, Patel M, Perry M. The Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC. American Journal Of Men's Health 2020, 14: 1557988320925985. PMID: 32602769, PMCID: PMC7328221, DOI: 10.1177/1557988320925985.Peer-Reviewed Original ResearchConceptsBody mass indexSperm healthPhysician practicesAssociated with low sperm motilitySperm countWorld Health OrganizationLow sperm motilitySample of U.S. menMen of colorLow sperm countNon-Hispanic menStudy sample sizeSperm motilitySperm concentrationSperm qualitySemen samplesSperm parametersSemen qualityObesity ratesSpermEpidemiological literatureU.S. menHispanic menMass indexAndrological health
2019
Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium
Kliman HJ, Frankfurter D. Clinical approach to recurrent implantation failure: evidence-based evaluation of the endometrium. Fertility And Sterility 2019, 111: 618-628. PMID: 30929719, DOI: 10.1016/j.fertnstert.2019.02.011.Peer-Reviewed Original ResearchConceptsRecurrent implantation failureImplantation failureHigh-quality embryosEvidence-based evaluationInflammatory markersRetained productsInflammatory lesionsHistologic evaluationQuality embryosClinical approachGrowth disordersActionable findingsEndometriumFunctional testsPatientsMolecular eraComplete assessmentTissueCycling tissueEndometrialFailureBest optionLesionsEvaluation
2018
Are too many eggs truly too many?
Comstock I, Frankfurter D. Are too many eggs truly too many? Fertility And Sterility 2018, 110: 632-633. PMID: 30196952, DOI: 10.1016/j.fertnstert.2018.05.030.Peer-Reviewed Original ResearchPerformance of retrieved oocytes that mature from metaphase I (MI) to metaphase II (MII) after a GnRH agonist trigger
Godiwala P, Humm K, Comstock I, Witmyer J, Peak D, Sparks A, Lalwani S, Frankfurter D. Performance of retrieved oocytes that mature from metaphase I (MI) to metaphase II (MII) after a GnRH agonist trigger. Fertility And Sterility 2018, 110: e312. DOI: 10.1016/j.fertnstert.2018.07.881.Peer-Reviewed Original ResearchTrophectodermal euploidy rates as a function of time to blastocoele expansion
Grant K, Comstock I, Humm K, Lalwani S, Peak D, Witmyer J, Frankfurter D. Trophectodermal euploidy rates as a function of time to blastocoele expansion. Fertility And Sterility 2018, 110: e351. DOI: 10.1016/j.fertnstert.2018.07.981.Peer-Reviewed Original Research
Clinical Care
Overview
David Frankfurter, MD, is a specialist in obstetrics, gynecology, and reproductive endocrinology and infertility (REI). He focuses on helping individuals address challenges related to reproduction and fertility, offering treatments such as hormone therapy and assisted reproductive technologies. He also supports patients to achieve family-planning goals.
As a professor of obstetrics, gynecology, and reproductive sciences at Yale School of Medicine, Dr. Frankfurter conducts research on hormonal influences on fertility and innovative reproductive techniques.
Dr. Frankfurter received his medical degree from Yale School of Medicine and completed his residency in obstetrics and gynecology at Yale New Haven Hospital, followed by a fellowship in reproductive endocrinology and infertility at Beth Israel Deaconess/Harvard University. After completing his training, he joined the Division of Reproductive Endocrinology at Brown University, where he became the director of the donor egg program. In 2003, he transitioned to George Washington University as the medical director of in vitro fertilization (IVF) and division director of REI. He returned to Yale in 2023.
Clinical Specialties
Reproductive Endocrinology & Infertility; Obstetrics, Gynecology & Reproductive Sciences
Fact Sheets
Polycystic Ovary Syndrome (PCOS)
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Board Certifications
Reproductive Endocrinology & Infertility
- Certification Organization
- AB of Obstetrics & Gynecology
- Original Certification Date
- 2002
Obstetrics & Gynecology
- Certification Organization
- AB of Obstetrics & Gynecology
- Original Certification Date
- 2000
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