Betty R. Lawton, PhD
Research Associate 2, MSDownloadHi-Res Photo
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Research Associate in Laboratory Medicine
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Titles
Research Associate 2, MS
Research Associate in Laboratory Medicine
Departments & Organizations
Education & Training
- Postdoctoral Fellow
- University of Connecticut (2010)
- PhD
- University of Connecticut, Genetics (2006)
Research
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Overview
Medical Research Interests
Erythrocytes; Parathyroid Glands; Pluripotent Stem Cells
ORCID
0000-0002-3164-4605
Research at a Glance
Yale Co-Authors
Frequent collaborators of Betty R. Lawton's published research.
Publications Timeline
A big-picture view of Betty R. Lawton's research output by year.
Research Interests
Research topics Betty R. Lawton is interested in exploring.
Diane Krause, MD, PhD
Courtney Elizabeth Gibson, MD, MS, FACS
Caroline Zeiss, DACVP, DACLAM
Madeline Mayday
Manju Prasad, MBBS, MD
Smita Krishnaswamy, PhD
8Publications
154Citations
Pluripotent Stem Cells
Parathyroid Glands
Publications
2024
Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue
Venkat A, Carlino M, Lawton B, Prasad M, Amodio M, Gibson C, Zeiss C, Youlten S, Krishnaswamy S, Krause D. Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue. Genome Research 2024, 34: 837-850. PMID: 38977309, PMCID: PMC11293540, DOI: 10.1101/gr.278215.123.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell statesMitochondrial transcript abundanceParathyroid glandsHuman parathyroidCell-cell communication analysisRNA expression analysisSingle-cell analysisTranscriptional dynamicsTranscript abundanceExpression dynamicsRNA transcriptomeEpithelial cell statesCell abundanceExpression analysisPseudotime analysis
2022
Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation
Scanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation. Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMegakaryocytic-erythroid progenitorsFate specificationLineage commitmentUnderstanding of hematopoiesisProgenitor cell biologyPrimary human hematopoietic progenitorsSingle-cell trackingSingle-cell assaysSingle-cell levelHuman hematopoietic progenitorsProgenitor cell dynamicsLineage specificationCell fateColony-forming unit assaysTimelapse imagingSitu fluorescence stainingCell biologyLineage tracingDivision rateCytokine thrombopoietinHematopoietic progenitorsProgenitorsFluorescence stainingCell dynamicsUnit assays
2020
Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells
Lawton BR, Martineau C, Sosa JA, Roman S, Gibson CE, Levine MA, Krause DS. Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells. Endocrinology 2020, 161: bqaa141. PMID: 32810225, PMCID: PMC7505176, DOI: 10.1210/endocr/bqaa141.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2013
Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells
Lawton BR, Sosa JA, Roman S, Krause DS. Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells. Stem Cell Reviews And Reports 2013, 9: 578-585. PMID: 23719997, DOI: 10.1007/s12015-013-9447-2.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsCell Culture TechniquesCell DifferentiationCell LineCell LineageCell MovementCell SurvivalCollagenDrug CombinationsEmbryonic Stem CellsEndodermFluorescent Antibody TechniqueGene Expression Regulation, DevelopmentalGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Hepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHumansLamininProteoglycansReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSOXF Transcription FactorsTime FactorsConceptsHuman embryonic stem cellsEmbryonic stem cellsDefinitive endodermEndodermal differentiationGene expression patternsStem cellsPrecardiac mesodermExpression patternsLow-serum mediumCell deathMesenchymal transitionMigratory characteristicsKey eventsEndodermDifferentiationCell viabilityActivin ASerum mediumCellsGastrulationImproved protocolMesodermInductionGenesNutrients
2008
Genomic imprinting of IGF2 in marsupials is methylation dependent
Lawton BR, Carone BR, Obergfell CJ, Ferreri GC, Gondolphi CM, VandeBerg JL, Imumorin I, O'Neill RJ, O'Neill MJ. Genomic imprinting of IGF2 in marsupials is methylation dependent. BMC Genomics 2008, 9: 205. PMID: 18454865, PMCID: PMC2386826, DOI: 10.1186/1471-2164-9-205.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMatrix attachment regionsGenomic imprintingSpecific CpG residuesParent-specific methylationSouth American opossum Monodelphis domesticaAllele-specific patternsMarsupial genomesTranscriptional silencingEvolutionary originImprinted lociImprinted genesSelective forcesCpG residuesEutherian mammalsBiallelic expressionDNA methylationRegulatory featuresCpG methylationKilobase regionOpossum Monodelphis domesticaKey regulatorPaternal Igf2 alleleIgf2 alleleMaternal alleleImprinting mechanism
2007
Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes
O'Neill MJ, Lawton BR, Mateos M, Carone DM, Ferreri GC, Hrbek T, Meredith RW, Reznick DN, O'Neill RJ. Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 12404-12409. PMID: 17636118, PMCID: PMC1941482, DOI: 10.1073/pnas.0705048104.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDarwinian selectionGenetic conflictPositive selectionComparative evolutionary analysisPositive Darwinian selectionNeutral mutation rateInsulin-like growth factor II geneLevel of phenotypeEvolution of placentationGrowth factor II geneRed Queen raceLevel of genesParent-offspring conflictFactor II genePlacental fishGene evolutionLivebearing fishOrder CyprinodontiformesAncient lineageGenomic imprintingStrong selectionEvolutionary analysisPlacental speciesAncient originNatural selectionPhysical mapping of the IGF2 locus in the South American opossum Monodelphis domestica
Lawton BR, Obergfell C, O’Neill R, O’Neill M. Physical mapping of the IGF2 locus in the South American opossum Monodelphis domestica. Cytogenetic And Genome Research 2007, 116: 130-131. PMID: 17268191, DOI: 10.1159/000097431.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSouth American opossum Monodelphis domesticaGenomic imprintingLarge-scale genome sequencing effortsOpossum Monodelphis domesticaGenome sequencing effortsInsulin-like growth factor II geneMonodelphis domesticaGrowth factor II geneFactor II geneGene functionModel organismsGene regulationSequencing effortsPhysical mappingIGF2 locusRegulatory mechanismsM. domesticaMarsupialsDomesticaImprintingRegulationGenesLociOrganismsMechanism
2005
Allelic expression of IGF2 in live-bearing, matrotrophic fishes
Lawton BR, Sevigny L, Obergfell C, Reznick D, O’Neill R, O’Neill M. Allelic expression of IGF2 in live-bearing, matrotrophic fishes. Discover Developmental Biology 2005, 215: 207-212. PMID: 15654625, DOI: 10.1007/s00427-004-0463-8.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsInsulin-like growth factor 2Parent-specific gene expressionGenomic imprinting predictsGrowth regulatory genesMatrotrophic fishPoeciliopsis prolificaTranscriptional silencingHeterandria formosaRegulatory genesFish speciesAllelic expressionEmbryonic developmentIGF2 activityGene expressionPlacental animalsDevelopmental expressionGrowth factor 2GenesParental investmentEmbryonic growthSpeciesFactor 2ExpressionVertebratesEutherians
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- Primary parathyroid cells in culture.
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