Begona Lainez-Mas
Associate Research ScientistCards
About
Research
Publications
2024
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease
Srivastava S, Zhou H, Shenoi R, Morris M, Lainez-Mas B, Goedeke L, Rajendran B, Setia O, Aryal B, Kanasaki K, Koya D, Inoki K, Dardik A, Bell T, Fernández-Hernando C, Shulman G, Goodwin J. Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease. Science Advances 2024, 10: eadn6068. PMID: 39630889, PMCID: PMC11616692, DOI: 10.1126/sciadv.adn6068.Peer-Reviewed Original ResearchConceptsAngiopoietin-like 4Diabetic kidney diseaseIntegrin B1Fibrogenic moleculesMutant miceSTING pathway activationIncreased fatty acid oxidationProgressive diabetic kidney diseaseDiabetic kidneyKidney diseaseReduced epithelial-to-mesenchymal transitionEpithelial-to-mesenchymal transitionFatty acid oxidationExpression of pro-inflammatory cytokinesTargeted pharmacological therapiesGene expressionMitochondrial damageEndothelial-to-mesenchymal transitionPro-inflammatory cytokinesPathway activationPharmacological therapyControl miceIntegrinAcid oxidationFibrogenic phenotype
2023
SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication
Meseguer S, Rubio M, Lainez B, Pérez-Benavente B, Pérez-Moraga R, Romera-Giner S, García-García F, Martinez-Macias O, Cremades A, Iborra F, Candelas-Rivera O, Almazan F, Esplugues E. SARS-CoV-2-encoded small RNAs are able to repress the host expression of SERINC5 to facilitate viral replication. Frontiers In Microbiology 2023, 14: 1066493. PMID: 36876111, PMCID: PMC9978209, DOI: 10.3389/fmicb.2023.1066493.Peer-Reviewed Original ResearchViral infectionSARS-CoV-2 viral infectionSARS-CoV-2 infectionCOVID-19 patientsMitochondrial antiviral signaling proteinInnate immunity factorsInnate immune responseVero E6 cellsSARS-CoV-2Viral proteinsImmune responseE6 cellsTherapeutic potentialViral replicationInfectionVero E6Immunity factorsSmall viral RNAsCertain virusesProtein 5SERINC5 expressionViral RNAHost expressionDifferent virusesVirus
2021
Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity
Tomayko MM, Karaaslan S, Lainez B, Conter LJ, Song E, Venkatesan S, Mishina Y, Shlomchik MJ. Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity. ImmunoHorizons 2021, 5: 284-297. PMID: 33975878, PMCID: PMC12221147, DOI: 10.4049/immunohorizons.2100019.Peer-Reviewed Original ResearchConceptsBone marrow-resident plasma cellsBone morphogenetic protein receptor 1AMemory B cellsMultiple stem cell populationsGene deletionStrong selective pressureGC B cellsStem cell populationGerminal centersB cellsReceptor 1aSelective pressureExpression studiesResultant establishmentNovel roleClass-switched memory B cellsEGFP reporter mice
2018
Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs.
Kim ST, Choi JY, Lainez B, Schulz VP, Karas DE, Baum ED, Setlur J, Gallagher PG, Craft J. Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs. The Journal Of Immunology 2018, 201: 1359-1372. PMID: 30030323, PMCID: PMC6112860, DOI: 10.4049/jimmunol.1701217.Peer-Reviewed Original ResearchConceptsMemory B cellsHumoral recall responsesB cell folliclesT cell subsetsB cellsTfh cellsCell subsetsRecall responsesT cellsInhibitory receptor PD-1Follicular helper T cellsGerminal center B-cell maturationIL-21 secretionChemokine receptor expressionReceptor PD-1Helper T cellsT cell zonesPrimary immune responseChemokine receptor CXCR5Transcription factor Bcl6B cell maturationTonsillar CD4IL-10IL-21PD-1
2016
TFH cells progressively differentiate to regulate the germinal center response
Weinstein JS, Herman EI, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. TFH cells progressively differentiate to regulate the germinal center response. Nature Immunology 2016, 17: 1197-1205. PMID: 27573866, PMCID: PMC5030190, DOI: 10.1038/ni.3554.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody AffinityB-LymphocytesCD4 AntigensCell CommunicationCell DifferentiationCells, CulturedGene Expression RegulationGerminal CenterHumansInterleukin-4InterleukinsMiceMice, Inbred C57BLMice, Mutant StrainsMutationNippostrongylusPositive Regulatory Domain I-Binding Factor 1Strongylida InfectionsT-Lymphocytes, Helper-InducerTranscription Factors
2015
A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W. A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. Cell Reports 2015, 13: 1118-1124. PMID: 26527008, PMCID: PMC4859432, DOI: 10.1016/j.celrep.2015.09.069.Peer-Reviewed Original ResearchConceptsCD8 T cellsChronic viral infectionsBATF expressionT cellsIL-21Chronic infectionEffector functionsViral infectionCD8 T cell effector functionsAnti-viral effector functionsCD8 T cell responsesCD8 T cell immunityT cell effector functionT cell immunityCD4 T cellsT cell responsesCell effector functionsT cell persistenceT cell maintenanceBlimp-1 expressionCD8 responsesCD4 helpCell immunityViral controlTranscription factor expressionProgressive differentiation of follicular B helper T cells regulates the germinal center response (IRC11P.430)
Herman E, Weinstein J, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. Progressive differentiation of follicular B helper T cells regulates the germinal center response (IRC11P.430). The Journal Of Immunology 2015, 194: 197.12-197.12. DOI: 10.4049/jimmunol.194.supp.197.12.Peer-Reviewed Original ResearchFollicular B helper T cellsHelper T cellsTfh cellsGerminal centersT cellsIL-21IL-4Thymus-dependent humoral immune responsesIL-21 mRNAB cell folliclesTfh cell differentiationCD4 T cellsHumoral immune responseSecondary lymphoid organsEffective antibody responseGerminal center responseAntibody-secreting cellsActivated B cellsTranscription factor Bcl6B cell maturationAntibody responseLymphoid organsImmune responseB cellsCenter response
2014
Dynamic signaling by T follicular helper cells during germinal center B cell selection
Shulman Z, Gitlin AD, Weinstein JS, Lainez B, Esplugues E, Flavell RA, Craft JE, Nussenzweig MC. Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science 2014, 345: 1058-1062. PMID: 25170154, PMCID: PMC4519234, DOI: 10.1126/science.1257861.Peer-Reviewed Original ResearchConceptsFollicular helper cellsB cellsGC B cellsHelper cellsGerminal centersAntibody-producing B cellsCytokine interleukin-4B cell selectionGerminal center B cell selectionInterleukin-4Transient elevationMajor histocompatibilitySustained increaseFree calciumClonal expansionCognate peptideIntravital imagingCell migrationCellsIntracellularCell selectionHigh levelsHistocompatibility
2011
Characterization of different subsets of human follicular helper T (TFH) cells (152.9)
Choi J, Kim S, Lainez B, Craft J. Characterization of different subsets of human follicular helper T (TFH) cells (152.9). The Journal Of Immunology 2011, 186: 152.9-152.9. DOI: 10.4049/jimmunol.186.supp.152.9.Peer-Reviewed Original ResearchFollicular helper T cellsB cell folliclesHelper T cellsTfh cellsT cellsIL-21P-selectin glycoprotein ligand-1IL-4Germinal centersB cellsTonsillar Tfh cellsIL-17 secretionExpression of CD127B cell helpAntigen-specific antibodiesGC B cellsTh17 cellsTfh subsetsPD-1Effector subsetsCell helpTherapeutic targetBCL-6RORC expressionHuman tonsils
2010
Clinical significance of high levels of soluble tumour necrosis factor-α receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study
Cañete J, Albaladejo C, Hernández M, Laínez B, Pinto J, Ramírez J, López-Armada M, Rodríguez-Cros J, Engel P, Blanco F, Sanmartí R. Clinical significance of high levels of soluble tumour necrosis factor-α receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study. Rheumatology 2010, 50: 721-728. PMID: 21134963, DOI: 10.1093/rheumatology/keq381.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAntibodies, MonoclonalAntirheumatic AgentsArthritis, RheumatoidBiomarkersCohort StudiesDisease ProgressionDose-Response Relationship, DrugFemaleHumansInfliximabLongitudinal StudiesMaleMatrix Metalloproteinase 1MethotrexateMiddle AgedProspective StudiesRadiographyReceptors, Tumor Necrosis Factor, Type IITreatment OutcomeTumor Necrosis Factor-alphaConceptsEuropean League Against RheumatismAnti-TNF-a therapySerum levelsACPA levelsRadiological evidenceRadiographic progressionRA patientsEULAR responseCohort 1Evidence of disease progressionRadiological evidence of disease progressionResponse to DMARDsDMARD-naive early RA patientsEarly RA patientsResponse to therapyLevels of MMP-1Longitudinal prospective cohort studyProspective cohort studyInfliximab therapyNL patientsMTX therapyRadiological progressionReceptor 2Clinical significanceCohort 2