Allysia Matthews, PhD
Associate Research ScientistCards
About
Research
Publications
2026
High-Grade Immune-Related Adverse Events Resulting from Immune Checkpoint Inhibitor Treatment: Evaluation of Diagnostics and Outcomes in Admitted Patients
Legakis L, Naagendran M, Matthews A, Morris J, Davies M, Prsic E, Price C. High-Grade Immune-Related Adverse Events Resulting from Immune Checkpoint Inhibitor Treatment: Evaluation of Diagnostics and Outcomes in Admitted Patients. Supportive Care In Cancer 2026, 34: 222. PMID: 41711961, DOI: 10.1007/s00520-026-10448-w.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsSevere immune-related adverse eventsLength of stayToxicity gradeCytokine signatureAdverse eventsAssociated with immune-related adverse eventsHigh-grade immune-related adverse eventsDiagnostic evaluationImmune checkpoint inhibitor treatmentMedian time to toxicityIL-6Checkpoint inhibitor treatmentHigh-grade toxicityPurposeImmune checkpoint inhibitorsRetrospective case reviewInterleukin (IL)-10ICI rechallengeCheckpoint inhibitorsICI initiationCorticosteroid treatmentPrimary cancerElevated CRPElevated biomarkersClinical outcomes
2025
Genetic polymorphisms associated with the development of immunotoxicity following immune checkpoint blockade
Legakis L, Raghavendra B, Xie Y, Matthews A, Zhao H, Price C. Genetic polymorphisms associated with the development of immunotoxicity following immune checkpoint blockade. The Journal Of Allergy And Clinical Immunology 2025, 155: ab7. DOI: 10.1016/j.jaci.2024.12.025.Peer-Reviewed Original Research
2018
AID phosphorylation regulates MMR during class switch recombination
Vuong B, Choi J, Matthews A, Michel G. AID phosphorylation regulates MMR during class switch recombination. The Journal Of Immunology 2018, 200: 48.10-48.10. DOI: 10.4049/jimmunol.200.supp.48.10.Peer-Reviewed Original ResearchBase excision repairWild-type levelsClass switch recombinationMismatch repairSwitch recombinationDNA break formationB cellsSpectrum of mutationsGenetic deletionKnock-in mutationPhosphorylation sitesTransition mutationsDNA breaksExcision repairMutationsWild-typePhosphorylationIntronIntermediate levelsUNGJH4DG mismatchesMSH2Recombination
2017
AID phosphorylation is required for base excision repair during class switch recombination
Matthews A, Choi J, Vuong B. AID phosphorylation is required for base excision repair during class switch recombination. The Journal Of Immunology 2017, 198: 195.19-195.19. DOI: 10.4049/jimmunol.198.supp.195.19.Peer-Reviewed Original Research
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May 202619Tuesday
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May 202626Tuesday
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