Alexander Joseph Rossi, MD
Assistant Professor of Surgery ( Colon & Rectal)Cards
About
Research
Publications
2025
Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth.
Sinha S, Panda A, Xavier das Neves R, Nwosu Z, Xu K, van Beek E, Desai P, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi A, Ayabe R, Wach M, McDonald J, Ruff S, Verbus E, Saif A, Eade A, Larrain C, Friedman L, Gupta S, Ranjan A, Teke M, Khan T, Pu T, Sarvestani A, Ryan C, Lambdin J, Luberice K, Gregory S, Lux S, Hong H, Luna A, Alexander I, Akmal S, Rehman S, Rainey A, Prickett T, Koparde V, Sevilla S, Kuhn S, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam M, Wu X, Jenkins L, Blakely A, Davis J, Trinchieri G, Singh P, Yang J, Pasca di Magliano M, Lyssiotis C, Yaffe M, Shevach E, Hernandez J. Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth. Cancer Discovery 2025, of1-of30. PMID: 41025961, DOI: 10.1158/2159-8290.cd-24-1055.Peer-Reviewed Original ResearchEndogenous competitive inhibitorTumor immunogenicityIntegrated stress responseImmune checkpoint blockadeExpression of MHC-I moleculesNK cell killingCell-mediated destructionAggressive epithelial tumorMetastatic tumor cellsMHC-I moleculesCheckpoint blockadeHepatic metastasesNK ligandsEpithelial tumorsNK cellsMetabolic plasticityMetastatic growthTumor cellsAmino acid transportDistant organsCell killingMetabolic controlTumorPancreatic cellsAcid transportExpression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Sinha S, Panda A, Xavier das Neves R, Nwosu Z, Xu K, van Beek E, Desai P, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi A, Ayabe R, Wach M, McDonald J, Ruff S, Verbus E, Saif A, Eade A, Larrain C, Friedman L, Gupta S, Ranjan A, Teke M, Khan T, Pu T, Sarvestani A, Ryan C, Lambdin J, Luberice K, Gregory S, Lux S, Hong H, Luna A, Alexander I, Akmal S, Rehman S, Rainey A, Prickett T, Koparde V, Sevilla S, Kuhn S, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam M, Wu X, Jenkins L, Blakely A, Davis J, Trinchieri G, Singh P, Yang J, Pasca di Magliano M, Lyssiotis C, Yaffe M, Shevach E, Hernandez J. Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth. Cancer Discovery 2025, 15: 2344-2373. PMID: 40736016, PMCID: PMC12580790, DOI: 10.1158/2159-8290.cd-24-1055.Peer-Reviewed Original ResearchImmune checkpoint blockadeEndogenous competitive inhibitorNatural killerExpression of MHC-I moleculesNK cell killingAggressive epithelial tumorMHC-I moleculesCheckpoint blockadeTumor immunogenicityHepatic metastasesNK cellsEpithelial tumorsMetastatic growthAmino acid transportCell killingMetabolic controlPancreatic cellsAcid transportTumorMouse liverMetabolic plasticityCDNA screeningCellsExpressionMetastasisAn Open-Source Normothermic Perfusion System Designed for Research Scientists.
Friedman L, Stepp H, Lambdin J, Luna A, Rossi A, Lux S, Wach M, Luberice K, Ruff S, McDonald J, Ayabe R, Rehman S, Ryan C, Gregory S, Eade A, Larrain C, Victory J, Pursley R, Noel T, Freidlin M, Gupta S, Pu T, Rainey A, Verbus E, Teke M, Saif A, Khan T, Alexander I, Sinha S, Akmal S, Maram R, Sarvestani L, Hewitt S, Doroshow J, Remmert K, Smith E, Desai P, Miao N, Driscoll K, West K, Heller T, Levy E, Davis J, Blakely A, Kleiner D, Kakareka J, Pohida T, Hernandez J. An Open-Source Normothermic Perfusion System Designed for Research Scientists. Journal Of Visualized Experiments 2025 PMID: 40758600, DOI: 10.3791/68722.Peer-Reviewed Original Research
2024
Acute esophageal necrosis in the post-operative period: a narrative review of presentation, management, and outcomes
Seitter S, Rossi A, Hernandez J, Nilubol N, Schrump D. Acute esophageal necrosis in the post-operative period: a narrative review of presentation, management, and outcomes. Journal Of Thoracic Disease 2024, 16: 7123-7131. PMID: 39552878, PMCID: PMC11565324, DOI: 10.21037/jtd-22-1763.Peer-Reviewed Original ResearchAcute esophageal necrosisPost-operative periodEsophageal necrosisMultiple comorbiditiesCase of acute esophageal necrosisRisk factorsMultisystem organ failureHistory of diabetesPost-operative patientsChronic kidney diseaseNarrative reviewLife-threatening conditionReview of presentationsGastric ulcer diseaseRoutine cholecystectomyUpper endoscopyOncological operationsCase reportHealthy patientsSevere morbidityOrgan failureDistal esophagusMucosal discolorationClinical conditionsKidney diseaseLocal Excision for Early-Stage Rectal Adenocarcinomas
Donohue K, Rossi A, Deek M, Feingold D, Patel N, Jabbour S. Local Excision for Early-Stage Rectal Adenocarcinomas. The Cancer Journal 2024, 30: 245-250. PMID: 39042775, DOI: 10.1097/ppo.0000000000000734.Peer-Reviewed Original ResearchConceptsTotal mesorectal excisionLocal excisionRectal adenocarcinomaTransanal minimally invasive surgeryLocal excision approachPreoperative chemoradiation therapyTransanal local excisionEarly-stage rectal adenocarcinomaEarly-stage tumorsTransanal endoscopic microsurgeryGroup of patientsStandard of careMinimally invasive surgeryDownstage tumorsChemoradiation therapyDeclined surgeryMesorectal excisionSurgical candidatesRectal cancerRectal circumferenceMultidisciplinary managementDentate lineEndoscopic microsurgeryExcision approachSurvival rate
2023
Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era
Gupta S, McDonald J, Rossi A, Hernandez J, Davis J, Blakely A. Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era. Foregut The Journal Of The American Foregut Society 2023, 4: 113-122. DOI: 10.1177/26345161231188677.Peer-Reviewed Original ResearchGastric mixed adenoneuroendocrine carcinomaGastric neuroendocrine carcinomaLymph node involvementMixed adenoneuroendocrine carcinomaOverall survivalGastric adenocarcinomaNode involvementAdenoneuroendocrine carcinomaMedian overall survival of patientsFactors associated with overall survivalPredictors of worse survivalAssociated with worse OSMultivariate Cox proportional hazards analysisOverall survival of patientsMedian overall survivalPathologic nodal metastasisCox proportional hazards analysisNational Cancer DatabaseProportional hazards analysisLymphovascular invasionNeuroendocrine carcinomaNodal metastasisPrognostic factorsDismal prognosisTumor sizeAppendiceal neoplasms—A practical guide
Rossi A, Patel N. Appendiceal neoplasms—A practical guide. Journal Of Surgical Oncology 2023, 127: 1300-1305. PMID: 37222692, DOI: 10.1002/jso.27304.Peer-Reviewed Original ResearchCreation of a perfusion machine for prolonged exvivo animation of resected tumor-bearing organs
Lambdin J, Luna A, Lux S, Luberice K, Ryan C, Stepp H, Rossi A, Sarvestani L, Gregory S, Akmal S, Davis J, Yaffe M, Kleiner D, Blakely A, Hernandez J. Creation of a perfusion machine for prolonged exvivo animation of resected tumor-bearing organs. Hepato Pancreato Biliary 2023, 25: s15-s16. DOI: 10.1016/j.hpb.2023.05.035.Peer-Reviewed Original Research
2022
Prevention of Implant Malposition in Latissimus Dorsi Myocutaneous Flap Breast Reconstruction Using an Acellular Dermal Matrix With Pectoralis Muscle Following Mastectomy for Breast Cancer: A Clinical Review.
Kachare M, Barrow B, Corey S, Elfanagely O, Rossi A, Simpson A, Kachare S, Choo J, Wilhelmi B. Prevention of Implant Malposition in Latissimus Dorsi Myocutaneous Flap Breast Reconstruction Using an Acellular Dermal Matrix With Pectoralis Muscle Following Mastectomy for Breast Cancer: A Clinical Review. Eplasty 2022, 22: e39. PMID: 36160664, PMCID: PMC9490880.Peer-Reviewed Original ResearchAcellular dermal matrixLatissimus dorsi myocutaneousLatissimus dorsi myocutaneous flapBody mass indexBreast reconstructionImplant malpositionRetrospective reviewBreast cancerEffect of breast reconstructionImplant-based breast reconstructionDermal matrixMean body mass indexImmediate implant placementMean follow-upFlap breast reconstructionInadequate soft tissue coverageCurrent smokingSoft tissue coverageImplant placementParticipant ageFlap necrosisBreast volumeSubpectoral implantsMass indexAesthetic resultsThe agony of acute anastomotic leak. Managing the emotional impact
Donohue K, Rossi A, Patel N. The agony of acute anastomotic leak. Managing the emotional impact. Seminars In Colon And Rectal Surgery 2022, 33: 100883. DOI: 10.1016/j.scrs.2022.100883.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Alexander Joseph Rossi, MD, is a colorectal surgeon who specializes in gastrointestinal surgery. He diagnoses and treats conditions related to the colon, rectum, and anus, such as colorectal cancer, diverticulitis, and inflammatory bowel disease. He takes a comprehensive approach to treating both cancerous and non-cancerous diseases of these areas and is skilled in minimally invasive surgical approaches.
As an assistant professor of surgery at Yale School of Medicine, Dr. Rossi is involved in research that aims to improve patient care and treatment. He chose this field, he says, because he is able to make meaningful and direct impacts on patients.
“I get to spend my days doing what I love, and the smiles and gratitude I get from the patients that I have the privilege to care for,” he says. “We will take care of them to the best of our ability at every step of the way.”
Dr. Rossi received his medical degree from Pennsylvania State University College of Medicine, followed by a general surgery internship and residency at Rutgers-Robert Wood Johnson Medical School. He also completed fellowships as a clinical staff fellow in surgical oncology at the National Institutes of Health | National Cancer Institute, and as a colon and rectal surgery fellow at the Ochsner Clinic.
Clinical Specialties
Colorectal Surgery; Gastrointestinal Surgery
Get In Touch
Contacts
Appointment Number
Mailing Address
Colorectal Surgery
Section of Gastrointestinal Surgery, Yale University School of Medicine P.O. Box 208062
New Haven, Connecticut 06511
United States
Administrative Support
Locations
Colorectal Surgery
Academic Office
350 George Street, Fl 3rd, Ste B393
New Haven, CT 06511
Patient Care Locations
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