Yale School of Medicine - For Humanity: Inflammation Pillar

Transcript

• 00:00As creative leaders in medicine and science,
• 00:04we constantly push boundaries to advance
• 00:06medicine for the benefit of humanity.
• 00:09We are at the leading edge of a
• 00:11new understanding of inflammation's
• 00:13role in human health, aging,
• 00:15and diseases such as Alzheimer's,
• 00:17multiple sclerosis, cancer, and more.
• 00:19I can't think of a single
• 00:22disease that doesn't involve
• 00:23inflammation in some way,
• 00:25for example. Currently,
• 00:26we're working on understanding sepsis,
• 00:28which is one of the.
• 00:30Clinically, extremely difficult
• 00:32conditions with high rate of mortality.
• 00:35We're discovering some simple ways
• 00:37to manipulate the inflammatory
• 00:39response under these conditions that
• 00:41result in improvement and survival.
• 00:43I think our work collectively
• 00:45on inflammation is impacting people's
• 00:47lives in a very tangible manner.
• 00:49We have started a PAC Slovak trial
• 00:52for treating patients with bone COVID
• 00:55with Doctor Hall from Health Group
• 00:57to look for biomarkers of people who
• 01:00respond positively so we can learn
• 01:02about the biology of this disease.
• 01:05As well as who benefits from Pak
• 01:08Sloven treatment or other antivirals.
• 01:10So we're studying specifically how
• 01:12the host age determines how we
• 01:15respond to different inflammatory
• 01:17signals such as viral infection,
• 01:19a process called inflammation,
• 01:21which means as we get older and older,
• 01:25our immune system is more prone
• 01:27to the inflammatory activation.
• 01:29Now that we understand these issues,
• 01:32we can try to better target therapeutics.
• 01:35Research at Yale Medical School has
• 01:37really been at the forefront of this
• 01:39movement and making new discoveries.
• 01:41That inform this new perspective on
• 01:44information and its role in aging
• 01:46and in diseases in general,
• 01:48neurodegenerative diseases like
• 01:50the Alzheimer's disease, as well as
• 01:52cancers, because in the case of cancers,
• 01:55inflammation plays a really dominant
• 01:57role in driving the development.
• 01:59Here at the old medical school,
• 02:02we are learning of the ways to either
• 02:05promote information when it's helpful or
• 02:07to suppress it when it's unhelpful. I've
• 02:10been very fortunate to have many
• 02:13collaborators across different
• 02:14discipline where we can ask very
• 02:17important questions that will hopefully
• 02:19directly help the patients. A
• 02:22gift to study inflammation will
• 02:23go a long way in fostering even
• 02:26more collaboration across the
• 02:27school and internationally,
• 02:29and that is potentially going
• 02:31to give us a leap that we need.
• 02:34To revolutionize this whole science
• 02:36on inflammation, Learn how your
• 02:38gift can help advance our understanding
• 02:40of inflammation with the goal of
• 02:42developing breakthrough treatments.
• 02:44Connect with a Development Officer today.