Gabriel Barsotti, MD, MHA
Associate Research ScientistCards
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Featured Publications
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran, A., Kumar, A., Lin, Q. et al. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nat Commun (2025). https://doi.org/10.1038/s41467-025-67854-7Peer-Reviewed Original ResearchA T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection
A T-cell intrinsic Role for APOL1 Risk Alleles in Allograft Rejection John Pell, EM Tanvir, Zeguo Sun, Irene Chernova, Anand Reghuvaran, Soichiro Nagata, Mateus Guerra, John Choi, Soltan Al Chaar, Hiroki Mizuno, Ke Dong, Xin Tian, Reika Ishibe, Barbara Franchin, Paolo Cravedi, Ashwani Kumar, Gabriel Barsotti, Hongmei Shi, Bony De Kumar, Wenzhi Song, Cijiang He, Jordan S Pober, Stefan Somlo, Ian W Gibson, Waldemar Popik, Zhongyang Zhang, Joseph Craft, Jamil Azzi, Naoka Murakami, Shuta Ishibe, Peter Heeger, Madhav C Menon bioRxiv 2025.07.14.664793; doi: https://doi.org/10.1101/2025.07.14.664793Peer-Reviewed Original Research
2026
APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection.
Pell J, Tanvir EM, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra MT, Choi J, Al Chaar S, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, De Kumar B, Smithson S, Song W, He JC, Chong AS, Pober JS, Somlo S, Gibson IW, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger PS, Menon MC. APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection. J Clin Invest 2026 PMID: 42262888, DOI: 10.1172/JCI193173.Peer-Reviewed Original ResearchQuantifying donor-recipient mismatches using recipient-derived sources of donor DNA
Quantifying donor-recipient mismatches using recipient-derived sources of donor DNA Nallakkandi Rajeevan, Gabriel Caldato Barsotti, Ashwani Kumar, Zeguo Sun, Anand Reghuvaran, Irina Tikhonova, E M Tanvir, Niketa Sareen, Ashley Swan, Richard Formica, Caleigh Mandel-Brehm, Arundati Rao, Whitney Besse, Maureen Miller, Laurine Bow, Bony De Kumar, Madhav C Menon medRxiv 2026.06.01.26354606; doi: https://doi.org/10.64898/2026.06.01.26354606Peer-Reviewed Original Research
2025
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.Peer-Reviewed Original ResearchConceptsROCK activitySmall molecule inhibitorsSHROOM3Wild typeAssociated with renal fibrosisCo-expressionRisk allelesTransgenic toolsPleiotropic effectsROCK inhibitionRho-kinaseOverexpressionCell linesPrecision therapeuticsFibroblast linesProfibrotic functionProfibrotic signalingMotifKidney diseaseEnhanced variantRenal fibrosisTubular cellsAlbuminuriaIn vivoMiceMechanisms of Podocyte Injury in Kidney Allografts
Barsotti, Gabriel C.1; Menon, Madhav C.1; Naik, Abhijit2; Rao, Arundati1,a. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 ():10.34067/KID.0000001091, December 05, 2025. | DOI: 10.34067/KID.0000001091Peer-Reviewed Original ResearchMechanisms of Podocyte Injury in Kidney Allografts.
Barsotti G, Menon M, Naik A, Rao A. Mechanisms of Podocyte Injury in Kidney Allografts. Kidney360 2025 PMID: 41348483, DOI: 10.34067/kid.0000001091.Peer-Reviewed Original ResearchMechanisms of podocyte injuryGraft lossNonimmune mechanismsAssociated with long-term graft lossLong-term kidney allograft survivalLong-term graft lossPodocyte injuryImmunosuppressive drug exposureChronic allograft failureChronic graft failureImmune mediated injuryAntibody mediated rejectionKidney allograft survivalAllograft survivalKidney allograftsAllograft failureTransplant settingGlomerular filtration barrierDrug exposureGraft failureImmune injuryClinical challengeInjuryFiltration barrierBiomechanical changesDesign and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx
Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney disease: Nephro-Dx Ashwani Kumar, Gabriel Caldato Barsotti, Zhengzi Yi, Zeguo Sun, Anand Reghuvaran, EM Tanvir, John Pell, Hongmei Shi, Sudhir Perincheri, Melissa Shaw, Candice Kent, Daris Javed, Petra Leite, Deepa Jayaram, Jeffrey Turner, Kristin Meliambro, Randy Luciano, John He, Dennis Moledina, Francis P Wilson, Weijia Zhang, Madhav C Menon medRxiv 2025.10.31.25338655; doi: https://doi.org/10.1101/2025.10.31.25338655Peer-Reviewed Original ResearchAPOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection
Pell J, Tanvir E, Sun Z, Azzi J, Murakami N, Reghuvaran A, Kumar A, Barsotti G, Ishibe S, Heeger P, Menon M. APOL1 Variants Promote T Cell Excitation by Modulating Calcium (Ca2+) Signaling Downstream of T Cell Receptors (TCRs) in Graft Rejection. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025kn5bktfx. DOI: 10.1681/asn.2025kn5bktfx.Peer-Reviewed Original ResearchUrine mRNA Assay to Measure Compartment-Specific Kidney Injury
Barsotti G, Kumar A, Yi Z, Pell J, Tanvir E, Moledina D, Luciano R, Reghuvaran A, Meliambro K, Perincheri S, Zhang W, He J, Menon M. Urine mRNA Assay to Measure Compartment-Specific Kidney Injury. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025c7mvzqgd. DOI: 10.1681/asn.2025c7mvzqgd.Peer-Reviewed Original Research
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