A Phase III Randomized Trial of Dose Escalated Radiation in Locally Advanced Pancreas Cancer (LAPC) Patients (LAP100)
Volunteers
Health Professionals
What is the purpose of this trial?
This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-6 months of chemotherapy. Usual care options include additional chemotherapy, observation, or standard lower-dose radiation therapy. These treatments may delay tumor growth but have not been shown to improve survival. Radiation therapy uses high energy X-rays to kill cancer cells and shrink tumors. Dose-escalated radiation therapy involves the precise delivery of higher doses to the tumor, often over a shorter period of time. This trial assesses whether using dose-escalated radiation therapy can prolong survival.
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.
Principal Investigator
Sub-Investigators
- Agatha Hecht
- Alessia Donadio, MD
- Allison Campbell, MD, PhD
- Andrea Brennan, PA
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS, MD
- Bruce A. McGibbon, MD
- Caitlin Gallagher, APRN
- Christina Carretta, APRN
- Claire Aurilio
- Clarice Grens, APRN
- D. Barry Boyd, MD, MS
- Daniel Hicks, MD
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Gabriela Spilberg, MD
- Jacquelyne Gaddy, MD, MSc, MSCR
- Jadwiga Kretowicz, APRN
- James Laird, MD
- Jeremy Kortmansky, MD
- Jill Lacy, MD
- Johanna LaSala, MD
- Jose Morales-Marin
- Justin Persico, MD
- Karen Ann Hammond, DNP, APRN, ACNP (BC)
- Katherine Harvey, MD, MPH
- Kayla Martello
- Kert Sabbath, MD, FACP
- Kimberly L. Johung, MD, PhD
- Kira Grogg, PhD
- Kristen Hoxie, PA
- Larisa Fleysher, APRN
- Laura Sabourin
- Lawrence Saperstein, MD
- M. Sung Lee, MD
- Madeline Santiago
- Megan Shulman, APRN
- Michael Burke
- Michael Cecchini, MD
- Michael Grant, MD
- Neal Fischbach, MD
- Nicholas Moore, MD
- Pamela L. Kunz, MD
- Pawan Karanam, MD
- Raghav Sundar, MD, PhD
- Rebecca Vanasse-Passas, MD
- Robert Matera, MD
- Sara Anastasio, APRN, RN
- Sarah Carlson, PA
- Sarah Thomen, APRN
- Sharynn Hall, MD, PhD
- Stacey LaRosa, APRN
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Teresa White, APRN
- Thejal Srikumar, MD, MPH
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy, APRN
- Wajih Kidwai, MD, FACP
- Yifei Zhang, MD
- Zia Rahman, MD
- Last Updated03/08/2026
- Study IRB#2000041320