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    <title>Latest news from Yale Depression Research Program</title>
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    <description>A selection of the latest research, academic, and other newsworthy developments at Yale Depression Research Program</description>
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    <copyright>Copyright 2026 Yale School of Medicine</copyright>
    <lastBuildDate>Fri, 15 May 2026 08:24:12 Z</lastBuildDate>
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      <title>CBT After Esketamine Can Prevent Relapses in Patients with Major Depression, Suicidal Ideation</title>
      <description>A new Yale-led study found that administration of cognitive behavioral therapy after a course of esketamine treatment can be effective in preventing relapse in patients with major depression and suicidal ideation. Samuel Wilkinson, MD, is lead author of the study, published in The Journal of Clinical Psychiatry.</description>
      <pubDate>Wed, 06 May 2026 04:00:00 Z</pubDate>
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      <title>Ketamine Infusions and Rapid Reduction of Suicidal and Depressive Symptoms in Major Depressive Episode</title>
      <description>A systematic review and meta-analysis of 26 randomized clinical trials with 1,166 patients with a major depressive episode found that ketamine was efficacious in reducing suicidal and depressive symptoms rapidly, within hours. Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of the paper, published in JAMA Psychiatry.</description>
      <pubDate>Wed, 06 May 2026 04:00:00 Z</pubDate>
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      <title>Adjunctive Antipsychotics in Major Depressive Disorder</title>
      <description>Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of a paper in JAMA Psychiatry that evaluates how FDA–approved atypical antipsychotics in major depressive disorder compare with respect to overall efficacy and acceptability.

</description>
      <pubDate>Wed, 06 May 2026 04:00:00 Z</pubDate>
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      <title>Trajectories of Late-Life Depression: Insights From Molecular Imaging</title>
      <description>Sophie Holmes, PhD, assistant professor of psychiatry, is first author of a paper in Neuropsychopharmacology that explores the use of molecular imaging to guide the development of treatments that could reduce the burden of late-life depression.</description>
      <pubDate>Tue, 21 Apr 2026 04:00:00 Z</pubDate>
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      <title>Yale Child, Adolescent, and Adult Psychiatry Program Announces Matched Residents</title>
      <description>Ben Coleman, MD, PhD, and Ann Johnson, PhD, will join the Albert J. Solnit Integrated Child, Adolescent, and Adult Psychiatry Program at Yale Child Study Center as new residents this summer. Coleman and Johnson were announced as part of the Department of Psychiatry’s 2026 Match Class, after the annual match process concluded in March. </description>
      <pubDate>Tue, 07 Apr 2026 14:00:00 Z</pubDate>
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      <link>https://www.nbcconnecticut.com/news/local/feeling-sad-how-to-beat-the-winter-blues/3711128/</link>
      <title>Feeling SAD? How To Beat the Winter Blues</title>
      <description>“During the winter months, we’re robbed of exposure to sunlight. In order to have vitamin D metabolized, you need sunlight. So people have low vitamin D levels, which is linked to depression,” said Robert Ostroff, MD, co-medical director of Interventional Psychiatry Service at Yale New Haven Psychiatric Hospital and clinical professor of Psychiatry at Yale School of Medicine.</description>
      <pubDate>Mon, 09 Mar 2026 04:00:00 Z</pubDate>
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      <link>https://jamanetwork.com/journals/jama/article-abstract/2845759</link>
      <title>Insufficient Sleep Among US Adolescents Across Behavioral Risk Groups</title>
      <description>Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of a paper in JAMA that found adolescents are suffering from insufficient sleep and that the problem is particularly pronounced among those with depressive symptoms or suicidal thoughts.</description>
      <pubDate>Wed, 04 Mar 2026 05:00:00 Z</pubDate>
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      <link>https://www.wfsb.com/2026/01/07/health-experts-say-dry-january-can-bring-measurable-benefits-just-31-days/</link>
      <title>Health Experts Say Dry January Can Bring Measurable Benefits in Just 31 Days</title>
      <description>One week into the new year, thousands of people across the country are participating in “Dry January,” a challenge to cut out alcohol for the entire month. “It’s a way of resetting after holiday spirits get a little bit out of hand and people tend to overdrink and overeat,” said Robert Ostroff, MD, co-medical director of interventional psychiatry at Yale New Haven Psychiatric Hospital.</description>
      <pubDate>Thu, 08 Jan 2026 05:00:00 Z</pubDate>
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      <title>Longitudinal Associations of Electroconvulsive Therapy with All-Cause Mortality and Suicide Deaths in Severe Unipolar or Bipolar Depression: A Systematic Review and Meta-Analysis</title>
      <description>Greg Rhee, PhD, associate professor adjunct in psychiatry, is first author of a paper in BMJ Mental Health that reviews the effects of electroconvulsive therapy on all-cause mortality and suicide deaths in severe unipolar or bipolar depression using longitudinal studies.</description>
      <pubDate>Thu, 18 Dec 2025 05:00:00 Z</pubDate>
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      <title>Analysis: Efficacy of Intranasal Esketamine Versus rTMS for Treatment-Resistant Depression</title>
      <description>Greg Rhee, PhD, associate professor adjunct in psychiatry, is senior author of a paper in eClinical Medicine that compares the effectiveness of repetitive transcranial magnetic stimulation, intranasal esketamine, and pharmacotherapy for treatment-resistant depression using data from two clinical trials.</description>
      <pubDate>Thu, 30 Oct 2025 04:00:00 Z</pubDate>
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      <link>https://www.wtnh.com/news/health/its-world-mental-health-day/</link>
      <title>It's World Mental Health Day</title>
      <description>On World Mental Health Day on October 10, Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, spoke to WTNH-TV News 8 about mental health as the seasons change, and his work with ketamine for treatment-resistant depression.</description>
      <pubDate>Fri, 10 Oct 2025 04:00:00 Z</pubDate>
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      <title>Beyond Symptom Improvement: Transdiagnostic and Disorder-Specific Ways to Assess Functional and Quality of Life Outcomes Across Mental Disorders in Adults</title>
      <description>Greg Rhee, PhD, associate professor adjunct in psychiatry, is co-author of a paper in World Psychiatry that provides an overview of the main tools to assess functioning, quality of life, and personal recovery outcomes across mental disorders in adults.</description>
      <pubDate>Tue, 16 Sep 2025 04:00:00 Z</pubDate>
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      <title>America's 'Alarming' Depression Problem</title>
      <description>"The increase (in adults suffering from or being treated for depression) is alarming, and it is important that we keep an open mind and explore all possible causes," Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, told Newsweek in a recent interview.</description>
      <pubDate>Tue, 16 Sep 2025 04:00:00 Z</pubDate>
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      <link>https://websites4-live-prod.ysmdevs.com/psychiatry/depression/news-article/yale-ohio-state-study-mobile-phone-app-reduced-suicidal-behavior-among-high-risk-patients/</link>
      <title>Yale Study: Mobile Phone App Reduced Suicidal Behavior Among High-Risk Patients</title>
      <description>A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among high-risk psychiatric inpatients, according to a new study by scientists at Yale School of Medicine and The Ohio State University Wexner Medical Center and College of Medicine.
</description>
      <pubDate>Fri, 08 Aug 2025 04:00:00 Z</pubDate>
      <content url="https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/83d00e14-d68d-4163-b94c-dc364909272f" alt="Photo of Patricia Simon, PhD; Samuel Wilkinson, MD; Alecia Dager, PhD; Seth Feuerstein, MD, JD" width="1200" height="630" xmlns="http://search.yahoo.com/mrss/" />
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      <link>https://websites4-live-prod.ysmdevs.com/psychiatry/depression/news-article/department-of-psychiatry-honors-residents-fellows-faculty-staff-at-2025-annual-commencement-ceremonies/</link>
      <title>Department of Psychiatry Honors Residents, Fellows, Faculty, Staff at 2025 Annual Commencement Ceremonies</title>
      <description>The Yale Department of Psychiatry honored 21 residents at the annual Yale Psychiatry Residency Program commencement ceremony June 17 at the New Haven Lawn Club.</description>
      <pubDate>Mon, 14 Jul 2025 04:00:00 Z</pubDate>
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      <link>https://www.washingtonpost.com/wellness/2025/07/02/ssri-heat-intolerance/</link>
      <title>What to do if Your SSRI is Making Hot Days Even Worse</title>
      <description>Psychiatrists John Krystal, MD, and Gerard Sanacora, MD, PhD spoke to The Washington Post about how SSRIs -- serotonin reuptake inhibitors -- can cause heat intolerance and how to stay safe on hot days.</description>
      <pubDate>Mon, 07 Jul 2025 04:00:00 Z</pubDate>
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      <link>https://www.nytimes.com/2025/06/06/health/ketamine-effects-anesthetic-elon-musk.html</link>
      <title>What to Know About the Effects of Ketamine</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, spoke to The New York Times about the benefits and possible dangers associated with the use of ketamine to treat depression, suicidal ideation and chronic pain.</description>
      <pubDate>Thu, 19 Jun 2025 04:00:00 Z</pubDate>
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      <link>https://pubmed.ncbi.nlm.nih.gov/40432341/</link>
      <title>National Trends in Suicidal Thoughts and Suicide Attempts Among High School Students in the United States</title>
      <description>Greg Rhee, PhD, FACE, associate professor adjunct in psychiatry, is senior author of a paper in American Journal of Psychiatry that observed increasing trends of suicidal thoughts and suicide attempts among U.S. high school students from 2007 to 2021. </description>
      <pubDate>Thu, 29 May 2025 04:00:00 Z</pubDate>
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      <link>https://www.nature.com/articles/s41588-025-02189-z#Sec34</link>
      <title>Genome-Wide Analyses Identify 30 Loci Associated with Obsessive–Compulsive Disorder</title>
      <description>A genome-wide analyses in Nature Genetics identified 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology. Marco Galimberti, PhD, associate research scientist, is co-first author.</description>
      <pubDate>Tue, 13 May 2025 04:00:00 Z</pubDate>
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      <link>https://websites4-live-prod.ysmdevs.com/psychiatry/depression/news-article/new-clinical-trial-aims-to-treat-depression-in-people-with-parkinsons-disease/</link>
      <title>New Clinical Trial Aims to Treat Depression in People with Parkinson’s Disease</title>
      <description>A new clinical trial launched by scientists at Yale School of Medicine and University of California San Francisco may offer hope to people with Parkinson’s disease who suffer from depression.

</description>
      <pubDate>Thu, 24 Apr 2025 04:00:00 Z</pubDate>
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      <link>https://image.message.yale.edu/lib/fe3815707564047e721779/m/1/9670cb74-9756-42ac-8b39-b99272bf5517.pdf</link>
      <title>Leading a Movement Away from Psychiatric Medication</title>
      <description>In a “taper,” patients encounter difficulties of two kinds: withdrawal, and the relapse of underlying conditions, explained Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, and director of the Yale Depression Research Program, in a story in The New York Times.</description>
      <pubDate>Tue, 18 Mar 2025 04:00:00 Z</pubDate>
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      <link>https://pubmed.ncbi.nlm.nih.gov/39937491/</link>
      <title>Making Progress in Clinical Trials for Suicide Prevention: A Review</title>
      <description>Researchers, including first author Samuel Wilkinson, MD, associate professor of psychiatry, and senior author Greg Rhee, PhD, associate professor adjunct in psychiatry, wrote in JAMA Psychiatry about the need to conduct clinical trials to prevent suicide.</description>
      <pubDate>Fri, 21 Feb 2025 05:00:00 Z</pubDate>
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      <title>New Device at Yale Interventional Psychiatry Service Shortens TMS Delivery Time for Most Patients</title>
      <description>A new device acquired by Yale Interventional Psychiatry Service has dramatically reduced the amount of time patients have to sit while undergoing transcranial magnetic stimulation for major depressive disorder.</description>
      <pubDate>Mon, 10 Feb 2025 05:00:00 Z</pubDate>
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      <link>https://websites4-live-prod.ysmdevs.com/psychiatry/depression/news-article/yale-led-study-will-compare-effectiveness-of-iv-ketamine-and-esketamine-nasal-spray/</link>
      <title>Yale-Led Study Will Compare Effectiveness of IV Ketamine and Esketamine Nasal Spray</title>
      <description>Patients are now being recruited for a study to compare the effectiveness of IV ketamine and esketamine nasal spray (otherwise known as Spravato) for people who suffer from treatment-resistant depression.</description>
      <pubDate>Wed, 15 Jan 2025 05:00:00 Z</pubDate>
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      <title>Common Questions About Antidepressants, Answered</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, spoke to The New York Times about some common questions and misconceptions about antidepressants. Sanacora is director of the Yale Depression Research Program.</description>
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      <title>Electroconvulsive Therapy (ECT) Has Changed: What You Should Know</title>
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      <pubDate>Wed, 23 Oct 2024 04:00:00 Z</pubDate>
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      <title>Bipolar Disorder Patients Respond to Ketamine, Esketamine Treatment</title>
      <description>A small sample of patients with bipolar disorder displayed noteworthy improvement in their depressive symptoms after being treated with the rapid-acting antidepressant intravenous ketamine and the nasal spray esketamine, according to a new Yale led-study. Mia Santucci, BA, postgraduate associate, and Samuel Wilkinson, MD, associate professor of psychiatry, are lead and senior authors, respectively.</description>
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      <title>People Are Injecting Ketamine at Home</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, spoke to The Wall Street Journal about ketamine's effect on the brain and why it can work as an antidepressant.</description>
      <pubDate>Tue, 20 Aug 2024 04:00:00 Z</pubDate>
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      <title>Psychedelics: Subjectivity in the Therapeutic Response</title>
      <description>Benjamin Kelmendi, MD, assistant professor of psychiatry, writes in Psychology Today about the new dimension psychedelic-assisted therapies bring to questions about subjectivity in psychiatry.</description>
      <pubDate>Thu, 23 May 2024 04:00:00 Z</pubDate>
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      <title>Depression — Understanding, Identifying, and Diagnosing</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry; and Sina Nikayin, MD, assistant professor of psychiatry, are featured in the first episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine.</description>
      <pubDate>Thu, 02 May 2024 04:00:00 Z</pubDate>
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      <title>What I Want My Patients to Know: Ketamine for Depression</title>
      <description>Samuel Wilkinson, MD, associate professor of psychiatry and associate director of the Yale Depression Research Program, writes in Psychology Today about the history of ketamine, its use to treat depression, and how it compares to esketamine.</description>
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      <title>Ketamine Therapy on the Rise for Treating Depression, Anxiety</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry and director of the Yale Depression Research Program, spoke to CNN about the use of ketamine to treat anxiety and depression.</description>
      <pubDate>Mon, 25 Mar 2024 04:00:00 Z</pubDate>
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      <title>Searching Science for Life's Purpose</title>
      <description>Samuel T. Wilkinson, MD, associate professor of psychiatry, is author of the new book "Purpose: What Evolution And Human Nature Imply About the Meaning of Our Existence?"</description>
      <pubDate>Tue, 05 Mar 2024 05:00:00 Z</pubDate>
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      <title>The Problem With Our Need to Achieve</title>
      <description>Samuel Wilkinson, MD, associate professor of psychiatry, writes about achievement and maintaining relationships in Time.</description>
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      <link>https://websites4-live-prod.ysmdevs.com/psychiatry/depression/news-article/harpaz-rotem-paper-named-2023-leading-research-achievement-by-bbrf/</link>
      <title>Duek, Harpaz-Rotem Paper Named '2023 Leading Research Achievement' by BBRF</title>
      <description>The paper "In PTSD, Evidence That a Single Ketamine Infusion May Enhance Extinction of Recalled Traumatic Memories" by Or Duek, PhD, assistant professor adjunct in psychiatry, and Ilan Harpaz-Rotem, PhD, professor of psychiatry and of psychology, has been named a 2023 Leading Research Achievement by the Brain &amp; Behavior Research Foundation.</description>
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      <title>Holmes Named Recipient of CINP's Rafaelsen Young Investigators Award</title>
      <description>Sophie E. Holmes, PhD, assistant professor of psychiatry and neurology, has been named a recipient of the Rafaelsen Young Investigators Award from the International College of Neuropsychopharmacology (CINP).</description>
      <pubDate>Thu, 21 Dec 2023 05:00:00 Z</pubDate>
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      <title>Ketamine and the Neurobiology of Depression: Toward Next-generation Rapid-acting Antidepressant Treatments</title>
      <description>John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology; and Irina Esterlis, PhD, associate professor of psychiatry, are first and senior authors, respectively, of a review published in Proceedings of the National Academy of Sciences Perspective that considers what scientists have learned from studies of ketamine and to suggest future directions for the optimization of rapid-acting antidepressant treatment.</description>
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      <link>https://websites4-live-prod.ysmdevs.com/psychiatry/depression/news-article/sanacora-wilkinson-receive-dollar126m-award-for-ketamine-study/</link>
      <title>Sanacora, Wilkinson Receive $12.6M in Funding for Ketamine Study</title>
      <description>Gerard Sanacora, MD, PhD (left), George D. and Esther S. Gross Professor of Psychiatry, and Samuel Wilkinson, MD, associate professor of psychiatry, have received $12.6 million in funding from the Patient-Centered Outcomes Research Institute (PCORI) for the study, “Comparative Effectiveness of Racemic Ketamine versus S-Ketamine (Spravato) for Depression.”</description>
      <pubDate>Tue, 28 Nov 2023 05:00:00 Z</pubDate>
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      <title>Ketamine Effectively Treats Depression. Do the Benefits Outweigh the Risks?</title>
      <description>Sophie Holmes, PhD, assistant professor of psychiatry, told National Geographic that continued research is needed to determine who might benefit from being treated by ketamine, the drug often prescribed in cases of severe depression and anxiety.</description>
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      <title>Wilkinson, Rhee Awarded NIH Research Project Grants</title>
      <description>Samuel Wilkinson, MD, associate professor of psychiatry, and Greg Rhee, PhD, assistant professor adjunct of psychiatry, have been awarded two grants through the National Institutes of Health Research Project Grants Program.</description>
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      <title>Nothing worked for her teenage son's depression, until his doctor suggested ketamine</title>
      <description>In this CNN Health story, a mother talks about her fears of losing her son to treatment-resistant depression, and a doctor's suggestion to try a medication off-label changed everything. YCSC Associate Professor Michael Bloch addresses some factors around ketamine treatment and research. </description>
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      <title>The Intricate Interaction Between Expectations and Therapeutic Outcomes of Psychedelic Agents</title>
      <description>Sina Nikayin, MD, assistant professor of psychiatry, and Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, are co-authors of a viewpoint in JAMA Psychiatry that explores how expectations influence outcomes of psychedelic drug therapy.</description>
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      <title>Long term Structural and Functional Neural Changes Following a Single Infusion of Ketamine in PTSD</title>
      <description>Or Duek, PhD, assistant professor adjunct of psychiatry, and Ilan Harpaz-Rotem, PhD, professor of psychiatry and of psychology, are first and senior authors, respectively of a study published in Neuropsychopharmacology that tests the potential of a single infusion of ketamine, followed by brief exposure therapy, to enhance post-retrieval extinction of post-traumatic stress disorder trauma memories.</description>
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      <title>Ketamine: Handle With Care</title>
      <description>Off-label, unsupervised use of ketamine has skyrocketed since regulatory changes were put in place at the height of the COVID pandemic. Yale psychiatrist Gerard Sanacora, a worldleader in ketamine research and clinical use, discusses some of the risks patients may be taking.</description>
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      <title>Sanacora, Holmes Discuss Ketamine's Impact on Depression on Podcast</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, and Sophie Holmes, PhD, assistant professor of psychiatry, Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, and Sophie Holmes, PhD, assistant professor of psychiatry, spoke about depression and mental health in Parkinson’s disease, as well as how ketamine can treat depression, on the Trembling EMT Podcast.</description>
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      <title>Time for a National Ketamine Registry, Experts Say</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry, spoke to Medscape about the effort to create a ketamine registry to collect data on dosage, treatment frequency, adverse events, and long-term outcomes in patients receiving the therapy for depression and other mental health conditions.</description>
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      <title>Beauty Supplements Are Everywhere. But Do They Actually Work?</title>
      <description>Gerard Sanacora, MD, PhD, George D. and Esther S. Gross Professor of Psychiatry; Director, Yale Depression Research Program, spoke to Harper's Bazaar for a story about the effectiveness of beauty supplements.</description>
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