Jeremiah Tsyporin
Postdoctoral AssociateAbout
Research
Publications
2026
Pyramidal neurons proportionately alter cortical interneuron subtypes
Wu S, Dai M, Yang S, McCann C, Qiu Y, Kumar V, Marrero G, Tsyporin J, Huang S, Shin D, Stogsdill J, Di Bella D, Xu Q, Chen B, Farhi S, Macosko E, Chen F, Fishell G. Pyramidal neurons proportionately alter cortical interneuron subtypes. Nature 2026, 651: 421-428. PMID: 41565808, DOI: 10.1038/s41586-025-09996-8.Peer-Reviewed Original Research
2024
A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex
Liang X, Hoang K, Meyerink B, Kc P, Paraiso K, Wang L, Jones I, Zhang Y, Katzman S, Finn T, Tsyporin J, Qu F, Chen Z, Visel A, Kriegstein A, Shen Y, Pilaz L, Chen B. A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2321711121. PMID: 38713624, PMCID: PMC11098099, DOI: 10.1073/pnas.2321711121.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineageCerebral CortexErbB ReceptorsEye ProteinsGene Expression Regulation, DevelopmentalHedgehog ProteinsHomeodomain ProteinsHumansMiceNerve Tissue ProteinsNeural Stem CellsNeurogenesisNeurogliaOlfactory BulbOligodendrocyte Transcription Factor 2Paired Box Transcription FactorsPAX6 Transcription FactorRepressor ProteinsSignal TransductionZinc Finger Protein Gli3ConceptsLineage switchRadial glial cellsNeural stem cellsOlfactory bulbProgenitor cellsCortical oligodendrocytesCortical progenitorsStem cellsCerebral cortexCortical neural stem cellsCortical progenitor cellsCortical radial glial cellsIntermediate progenitor cellsOB interneuronsInterneuron neurogenesisInhibitory neuronsExcitatory neuronsGlial cell typesSpinal cordGlial cellsNeurogenesis to gliogenesisShh signalingTranscriptional regulationCell typesPrecocious expression
2023
Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells
Horton C, Liu Y, Wang J, Green J, Tsyporin J, Chen B, Wang Z. Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells. Stem Cell Reports 2023, 18: 1355-1370. PMID: 37172587, PMCID: PMC10277819, DOI: 10.1016/j.stemcr.2023.04.003.Peer-Reviewed Original Research
2021
Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons
Tsyporin J, Tastad D, Ma X, Nehme A, Finn T, Huebner L, Liu G, Gallardo D, Makhamreh A, Roberts JM, Katzman S, Sestan N, McConnell SK, Yang Z, Qiu S, Chen B. Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons. Cell Reports 2021, 35: 109269. PMID: 34161768, PMCID: PMC8327856, DOI: 10.1016/j.celrep.2021.109269.Peer-Reviewed Original ResearchConceptsLayer 6 corticothalamic neuronsNeuron subtype identityCortical projection neuronsSubtype-specific characteristicsGlutamatergic identitySubcerebral neuronsCorticothalamic neuronsCerebral cortexProjection neuronsAxonal projectionsNeuron phenotypeNeuronal subtypesNeuronsProgenitor cellsSubtype identityMultiple parallel pathwaysExpression of genesTerminal differentiation programNeuronal genesFezf2Differentiation programPrevious studiesGlutamatergicGenesCortex
2020
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
Zhang Y, Liu G, Guo T, Liang X, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein A, Rubenstein J, Yang Z, Chen B. Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. Cell Reports 2020, 30: 4490-4504.e4. PMID: 32234482, PMCID: PMC7197103, DOI: 10.1016/j.celrep.2020.03.027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBiomarkersCell LineageEmbryo, MammalianHedgehog ProteinsHomeodomain ProteinsInterneuronsMice, Inbred C57BLNeocortexNerve Tissue ProteinsNeural Stem CellsNeurogenesisNeurogliaOlfactory BulbOligodendrogliaPyramidal CellsReproducibility of ResultsSignal TransductionZinc Finger Protein Gli3ConceptsNeocortical neural stem cellsIntermediate progenitor cellsNeural stem cellsOlfactory bulbLineage switchCortical oligodendrocytesCortical neural stem cellsGlutamatergic projection neuronsSonic hedgehog signalingLineage-tracing studiesOB interneuronsG-aminobutyric acidSignaling molecule Sonic hedgehogStem cell lineage progressionTranscriptional profilesProjection neuronsProgenitor cellsSingle-cell RNA sequencingStem cellsSonic hedgehogCell lineage progressionProtein levelsHedgehog signalingLineage progressionPrenatal neocortex
2019
Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
Kim G, Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Akhtar A, Linesch P, Kobritz N, Chandra S, Grausam K, Ayala-Sarmiento A, Molina J, Sedivakova K, Hoang K, Tsyporin J, Gareau D, Filbin M, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva M, Chen B, Danielpour M, Breunig J. Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell 2019, 179: 251-267.e24. PMID: 31539496, PMCID: PMC6934691, DOI: 10.1016/j.cell.2019.08.013.Peer-Reviewed Original ResearchConceptsLocus-specificRecombinase-mediated cassette exchangeChromosomal lociMutant cellsRapid generationMosaic analysisCassette exchangeCopy numberMosaic miceTransgenesis methodHuman cellsTransgenic manipulationGlioma modelPediatric gliomasDriver mutationsLociTransgenic miceMouse linesRecombinase expressionStable labelingMiceTransgenic elementsCombination labelingGliomaMADRS
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100 College Street, Rm 1020
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