Li Yan McCurdy, PhD
Assistant ProfessorAbout
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Assistant Professor
Biography
Dr. McCurdy is an Assistant Professor in the Department of Psychiatry at Yale School of Medicine. Her program of research is centered on facilitating addiction recovery through empowerment and social connection. She has been involved in the development and evaluation of scalable digital interventions for addiction, including her social support intervention designed to support individuals in early addiction recovery by increasing engagement with recovery community resources.
Dr. McCurdy earned her Ph.D. in neuroscience at Yale University in 2020, where she identified the neural mechanisms for unlearning memories in the fruit fly. She then completed two National Institute on Drug Abuse (NIDA) T32 postdoctoral research fellowships at Yale School of Medicine: the Division of Prevention and Community Research’s training program in substance use prevention and the Neuroimaging Sciences Training Program. She joined the Department of Psychiatry at Yale School of Medicine as an Assistant Professor in January 2025.
Appointments
Psychiatry
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Yale University, Neuroscience (2020)
- BA
- Columbia University, Biochemistry (2012)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-8862-6715- View Lab Website
The Nurturing Addiction Recovery & Wellness Lab (NARWL)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Brian D. Kiluk, PhD
Marc Potenza, PhD, MD
Charla Nich
Grace Kong, PhD
Suchitra Krishnan-Sarin, PhD
Elise DeVito, PhD
Social Support
Publications
Featured Publications
Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila
McCurdy LY, Sareen P, Davoudian PA, Nitabach MN. Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila. Nature Communications 2021, 12: 1115. PMID: 33602917, PMCID: PMC7893153, DOI: 10.1038/s41467-021-21388-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDopaminergic neuronsCholinergic neuronsNeural circuit mechanismsCholinergic relayDopaminergic mechanismsSynaptic excitationSynaptic reconstructionSynaptic inputsVivo functional imagingCircuit mechanismsNeuronsAversive memoryFunctional imagingOdor responsesAversive outcomesReduced activationSuch activationCircuit motifsActivationOutcomesElectric shock punishmentSensory cuesUnexpected omissionShock punishmentBehavioral analysisStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCitationsConceptsCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellumDevelopment and Pilot Test of a Novel Digital Social Support Intervention for Reducing Hazardous Alcohol Use
McCurdy L, Chung T, Stryjewski A, Spitzen T, Nich C, Krishnan‐Sarin S, Kong G, Kiluk B, Potenza M. Development and Pilot Test of a Novel Digital Social Support Intervention for Reducing Hazardous Alcohol Use. Alcohol Clinical And Experimental Research 2026, 50: e70301. PMID: 42026745, PMCID: PMC13106737, DOI: 10.1111/acer.70301.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHazardous alcohol usePost-interventionAlcohol useSocial support interventionsSources of social supportSurvey post interventionAddiction recoveryPost-treatment assessmentSupport interventionsPre-interventionDigital interventionsSocial supportDescriptive statisticsGoal settingAlcohol consumptionQuit drinkingOrganization engagementPilot testRecruitment ratesRecovery organizationsParticipantsInterventionEngagement ratesVideo messagesPreliminary efficacy results
2023
A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use
McCurdy L, Kong G, Krishnan-Sarin S, Kiluk B, Potenza M. A non-randomized pilot study protocol of a novel social support intervention for individuals in early recovery from hazardous alcohol use. PLOS ONE 2023, 18: e0292293. PMID: 37796784, PMCID: PMC10553253, DOI: 10.1371/journal.pone.0292293.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRecovery support servicesHazardous alcohol useSocial support interventionsAlcohol usePilot studyEarly recoverySupport interventionsPilot study protocolMixed methods pilot studyOnline social support interventionQuality of lifeSupport servicesSelf-reported changesPrimary outcomeSecondary outcomesStudy protocolHazardous alcohol
2013
Anatomical Coupling between Distinct Metacognitive Systems for Memory and Visual Perception
McCurdy L, Maniscalco B, Metcalfe J, Liu K, de Lange F, Lau H. Anatomical Coupling between Distinct Metacognitive Systems for Memory and Visual Perception. Journal Of Neuroscience 2013, 33: 1897-1906. PMID: 23365229, PMCID: PMC4696871, DOI: 10.1523/jneurosci.1890-12.2013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMetacognitive efficiencyFrontal polar regionsGray matter volumeMetacognitive systemKinds of metacognitionMatter volumeDistinct brain structuresVoxel-based morphometry analysisMemory taskBehavioral correlationsMetacognitive mechanismsMetacognitive tasksModel comparison analysisMemory processingPrecuneus volumeVisual perceptionAnatomical couplingStructural covariationPsychophysical measuresPrecuneus regionsMetacognitionHuman brainBrain structuresMorphometry analysisTask
Clinical Trials
Current Trials
A digital intervention for reducing stimulant drug use
IRB ID2000040872RolePrincipal InvestigatorPrimary Completion Date11/15/2026Recruiting ParticipantsGenderBothAge18+ years
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