I-Uen "Yvonne" Hsu, PhD
Postdoctoral Associate in NeuroscienceAbout
Research
Publications
Featured Publications
Lineage and organ signals sequentially build organ intrinsic nervous systems.
Hsu IY, Zhao J, Lin Y, Guo Y, Xu QJ, Shao Y, Wang RL, Yin D, Ghoshal K, Mourad R, Pozzi A, Halabi CM, Young LH, Zhao H, Zhang L, Chang RB. Lineage and organ signals sequentially build organ intrinsic nervous systems. Nature 2026 PMID: 42129551, DOI: 10.1038/s41586-026-10490-y.Peer-Reviewed Original ResearchStac protein regulates release of neuropeptides
Hsu IU, Linsley JW, Zhang X, Varineau JE, Berkhoudt DA, Reid LE, Lum MC, Orzel AM, Leflein A, Xu H, Collins CA, Hume RI, Levitan ES, Kuwada JY. Stac protein regulates release of neuropeptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29914-29924. PMID: 33168737, PMCID: PMC7703553, DOI: 10.1073/pnas.2009224117.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBehavior Observation TechniquesBehavior, AnimalCalcium ChannelsDrosophila melanogasterDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsIntravital MicroscopyLarvaMaleModels, AnimalMotor NeuronsMuscle, SkeletalNeuromuscular JunctionNeuropeptidesOptical ImagingPatch-Clamp TechniquesPresynaptic TerminalsConceptsSTAC proteinsRelease of neuropeptidesVertebrate skeletal muscleSubset of neuronsMolecular regulationGenetic manipulationKey regulatorMotor neuronsCytosolic CaNumerous neural functionsSmall familyCentral nervous systemExcitation-contraction couplingGenesSkeletal muscleL-type CaProteinNeuropeptide releaseNervous systemNeural functionDrosophilaNeuropeptidesVertebratesNeuronsRegulator
2025
Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience.
Xu QJ, Applegate MC, Hsu IU, Kogan RP, Hafez OA, Wang RL, Rios Coronado PE, Young LH, Zeng X, Zhang L, Chang RB. Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience. BioRxiv 2025 PMID: 40661461, DOI: 10.1101/2025.06.13.659555.Peer-Reviewed Original Research
2024
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997-eabo1997. PMID: 39475571, PMCID: PMC12372474, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerability
2023
Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer’s disease
Sanotra M, Kao S, Lee C, Hsu C, Huang W, Chang T, Tu F, Hsu I, Lin Y. Acrolein adducts and responding autoantibodies correlate with metabolic disturbance in Alzheimer’s disease. Alzheimer's Research & Therapy 2023, 15: 115. PMID: 37349844, PMCID: PMC10286356, DOI: 10.1186/s13195-023-01261-2.Peer-Reviewed Original ResearchConceptsMetabolic disturbancesHealthy controlsPotential biomarkersAcrolein adductAPP C-terminal fragmentsAD model cellsAD cell modelAmyloid precursor proteinHuman samplesInvolvement of MetMetS groupNeuro-2a cellsSpecific autoantibodiesMetabolic syndromeBackgroundAlzheimer’s diseaseClinical dataMetabolic aberrationsAutoantibodiesMouse modelAlzheimer's diseaseMouse serumAß peptideMetS conditionsSerum samplesDisease
2020
Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles
Hsu IU, Linsley JW, Reid LE, Hume RI, Leflein A, Kuwada JY. Dstac Regulates Excitation-Contraction Coupling in Drosophila Body Wall Muscles. Frontiers In Physiology 2020, 11: 573723. PMID: 33123029, PMCID: PMC7573238, DOI: 10.3389/fphys.2020.573723.Peer-Reviewed Original ResearchExcitation-contraction couplingL-type voltage-gated calcium channelsVoltage-gated calcium channelsSubset of neuronsBody wall musclesL-type CaCalcium channelsNormal expression levelsEC couplingMuscle contractionSkeletal muscleSpecific antibodiesMuscleLarval body wall musclesDmca1DExpression levelsWall musclesNormal locomotionDrosophila body wall musclesNeuronsVertebrate skeletal muscleAntibodiesDeficient larvae
2019
Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease
Sheu JJ, Yang LY, Sanotra MR, Wang ST, Lu HT, Kam RSY, Hsu IU, Kao SH, Lee CK, Shieh JC, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease. Clinical Biochemistry 2019, 76: 24-30. PMID: 31786207, DOI: 10.1016/j.clinbiochem.2019.11.011.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD seraAD patientsEarly diagnosisAD model mouse brainsC-terminal APP fragmentsMini-Mental State Examination scoreSerum samplesHealthy control subjectsState Examination scoreBlood-based biomarkersModel mouse brainProbable Alzheimer's diseaseAge-dependent mannerGood diagnostic performanceHC seraControl subjectsAPP fragmentsAD biomarkersMouse brainYounger ageAD diagnosisNeuronal cellsWestern blottingDisease
2018
Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease
Lin CY, Sheu JJ, Tsai IS, Wang ST, Yang LY, Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141–147 in Taiwanese with Alzheimer's disease. Clinical Biochemistry 2018, 56: 75-82. PMID: 29680706, DOI: 10.1016/j.clinbiochem.2018.04.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAntibody SpecificityApolipoprotein A-IAutoantibodiesAutoimmunityBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGlycation End Products, AdvancedHumansImmunoglobulin MLysineMalePeptide FragmentsProtein Processing, Post-TranslationalPsychiatric Status Rating ScalesROC CurveTaiwanUp-RegulationConceptsAdvanced glycation end productsSpecific advanced glycation end productsAlzheimer's diseaseMini-Mental State Examination scoreMental State Examination scoreEarly AD markersEarly AD pathologyState Examination scoreEarly disease statesGlycation end productsRelated autoantibodiesAD markersIgM levelsAD pathologyElevated IgMAD seraAD patientsDisease progressionAD biomarkersApolipoprotein A1IgMAutoantibodiesApoA1Serum samplesWestern blottingDstac is required for normal circadian activity rhythms in Drosophila
Hsu IU, Linsley JW, Varineau JE, Shafer OT, Kuwada JY. Dstac is required for normal circadian activity rhythms in Drosophila. Chronobiology International 2018, 35: 1016-1026. PMID: 29621409, PMCID: PMC6103890, DOI: 10.1080/07420528.2018.1454937.Peer-Reviewed Original ResearchConceptsPigment Dispersing FactorS-LNSmall ventrolateral neuronsBrain of DrosophilaL-type voltage-gated CaCircadian activityNovel genesAdaptor proteinCircadian locomotionVoltage-gated CaActivity rhythmsDrosophilaDmca1DGenesVentrolateral neuronsCircadian activity rhythmsVertebratesSTAC3ProteinBindsCACHActivity
2017
Transport of the alpha subunit of the voltage gated L‐type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles
Linsley JW, Hsu I, Wang W, Kuwada JY. Transport of the alpha subunit of the voltage gated L‐type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles. Traffic 2017, 18: 622-632. PMID: 28697281, PMCID: PMC5569907, DOI: 10.1111/tra.12502.Peer-Reviewed Original ResearchConceptsEC couplingL-type calcium channelsSkeletal muscleL-type voltageExcitation-contraction couplingCongenital myopathyCalcium channelsLongitudinal SRSarcoplasmic reticulumDHPRMembrane depolarizationMuscle fibersTubule membranesMuscleSR membranesAlpha subunitSarcoplasmic reticulum membranesDynamic imagingBeta subunitMembrane voltageTriadPrecise localizationTherapyMyopathy
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