Gehlhausen Lab

The Gehlhausen Lab investigates the biology of autoimmune inflammatory skin diseases, with a focus on understanding how aberrant immune signaling drives tissue damage in conditions like cutaneous lupus erythematosus and dermatomyositis. Our work bridges bench and bedside: we combine genetic mouse models of autoimmunity with high-dimensional profiling of patient-derived samples from our connective tissue disease clinic at Yale Dermatology. By integrating technologies including single-cell RNA sequencing, spatial transcriptomics, high-parameter flow cytometry, and interpretable artificial intelligence, we aim to uncover the cellular and molecular mechanisms of disease and translate these findings into new diagnostic and therapeutic strategies.

We are part of the Department of Dermatology at Yale School of Medicine and collaborate closely with the Iwasaki Lab and the Yale Lupus Program.

The Gehlhausen Lab is committed to rigorous, translational science that directly benefits patients with autoimmune skin disease. We foster a collaborative, inclusive environment where trainees at every level—from medical students to postdoctoral fellows—are supported in developing as independent scientists and clinicians. We value intellectual curiosity, scientific integrity, and the integration of clinical observation with fundamental discovery.

We welcome inquiries from motivated medical students, graduate students, postdoctoral fellows, and research staff interested in autoimmune skin disease or translational immunology. Please email jeffrey.gehlhausen@yale.edu with a cover letter and CV if you are interested in joining the lab.