https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-rss/?orgId=114964&title=Latest+News A selection of the latest research, academic, and other newsworthy developments at De Camilli Lab en-us Copyright 2026 Yale School of Medicine Thu, 14 May 2026 23:23:10 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/pietro-de-camilli-and-the-cell-biology-of-neurons/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/pietro-de-camilli-and-the-cell-biology-of-neurons/ Pietro De Camilli always wanted to be a scientist. He has spent his career bridging cell biology and neuroscience. Wed, 13 May 2026 17:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/how-cells-communicate/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/how-cells-communicate/ Yale research uncovered how vesicles fuse and recycle, revealing core mechanisms of cellular communication. Tue, 24 Feb 2026 05:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/damaged-cell-trash-cans-may-contribute-to-parkinsons-disease/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/damaged-cell-trash-cans-may-contribute-to-parkinsons-disease/ A new study on a gene called VPS13C adds to growing evidence that lysosomal dysfunction may be one mechanism through which Parkinson’s disease arises. Thu, 10 Apr 2025 09:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/traineetuesday-sydney-cason-phd/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/traineetuesday-sydney-cason-phd/ This #TraineeTuesday, we introduce Sydney Cason, PhD, a Postdoctoral Associate in the De Camilli Lab! She was recently awarded the Life Sciences Research Foundation (LSRF) Postdoctoral Fellowship, a prestigious private award that provides three years of salary and research allowance. Tue, 11 Mar 2025 16:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/three-yale-school-of-medicine-led-teams-awarded-dollar18-million-to-advance-parkinsons-disease-research/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/three-yale-school-of-medicine-led-teams-awarded-dollar18-million-to-advance-parkinsons-disease-research/ Yale School of Medicine teams have received three grants totaling $18 million from Aligning Science Across Parkinson’s (ASAP), a coordinated research initiative devoted to accelerating the pace of discovery and informing the path to a cure for Parkinson’s disease (PD) research. Thu, 21 Nov 2024 05:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/precision-medicine-for-parkinsons-new-yale-center-for-advanced-research/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/precision-medicine-for-parkinsons-new-yale-center-for-advanced-research/ The new Yale center is the first to focus on developing precision medicine for Parkinson’s disease. Mon, 14 Oct 2024 18:25:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/sydney-cason-receives-life-science-research-foundation-award/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/sydney-cason-receives-life-science-research-foundation-award/ Neuroscience and Cell Biology postdoctoral fellow Sydney Cason, PhD, is one of the 21 Life Science Research Foundation 2024 Awardees. Thu, 01 Aug 2024 16:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/hao-chen-and-bhaskar-honored-with-2024-kavli-postdoctoral-fellowship/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/hao-chen-and-bhaskar-honored-with-2024-kavli-postdoctoral-fellowship/ The Kavli Institute for Neuroscience is pleased to announce the recipients of the 2024 Kavli Postdoctoral Fellowship: Drs. Hongyan Hao, Kevin Chen, and Dhananjay Bhaskar. Fri, 03 May 2024 15:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/traineetuesday-chase-amos/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/traineetuesday-chase-amos/ This #TraineeTuesday, we are highlighting Chase Amos, a graduate student in the De Camilli Lab! He recently published a report in Contact on the connection between the two proteins VPS13A and XK in red blood cell precursors, and a paper in Molecular Biology of the Cell. Tue, 06 Feb 2024 16:00:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/yale-researchers-key-neuronal-transport-system/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/yale-researchers-key-neuronal-transport-system/ A team of Yale neuroscience researchers sheds light on the early steps of a transport event. Tue, 15 Aug 2023 15:05:00 Z https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/de-camilli-awarded-the-van-deenan-medal-for-biomembrane-research/ https://websites4-live-prod.ysmdevs.com/lab/decamilli/news-article/de-camilli-awarded-the-van-deenan-medal-for-biomembrane-research/ Pietro de Camilli, MD, John Klingenstein Professor of Neuroscience and professor of Cell Biology, was awarded the van Deenen Medal. Thu, 27 Apr 2023 04:00:00 Z https://news.yale.edu/2022/07/14/yale-scientists-zero-genetic-causes-parkinsons https://news.yale.edu/2022/07/14/yale-scientists-zero-genetic-causes-parkinsons In two new papers, scientists provide insight into the function of a protein called VPS13C, one of the molecular suspects that underlie Parkinson’s, a disease marked by uncontrollable movements including tremors, stiffness, and loss of balance. Thu, 14 Jul 2022 04:00:00 Z https://proxy.qualtrics.com/proxy/?url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs42003-021-02945-x&token=f7c1318WSPeifJl3BU62cUPZjo3WLm36YvLkHxzUJCg%3D https://proxy.qualtrics.com/proxy/?url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs42003-021-02945-x&token=f7c1318WSPeifJl3BU62cUPZjo3WLm36YvLkHxzUJCg%3D New research from the De Camilli and Ferguson labs reveals a close relationship between the transport of lysosomes and cytoskeleton organization in neuronal axons through studies of human ipSC-derived neurons lacking JIP3/MAPK8IP3, a scaffold protein that is thought to link lysosomes to motors. These findings raise new questions about how the transport of cargos is coordinated with the structure and dynamics of multiple components of the axonal cytoskeleton. Answers to these questions may be relevant to human neurdevelopmental disease arising from mutations in the JIP3/MAPK8IP3 gene as well as for Alzheimer’s disease where lysosomes accumulate in axonal swellings at amyloid plaques. Mon, 10 Jan 2022 04:00:00 Z https://elifesciences.org/articles/63230 https://elifesciences.org/articles/63230 Light-inducible dimerization protein modules enable precise temporal and spatial control of biological processes in non-invasive fashion. Among them, Magnets are photoreceptors requiring simultaneous photoactivation to interact, enabling high spatiotemporal confinement of dimerization with a single-excitation wavelength. However, Magnets require concatemerization for efficient responses and cell preincubation at 28oC to be functional. We overcame the limitations by structure-guided protein engineering and validation by cellular assays. The resulting reagents, “enhanced Magnets” (eMags), have greater thermal stability and dimerization efficiency, as well as faster association and dissociation kinetics. We confirmed their effectiveness in several applications including protein recruitment to different organelles, the generation/expansion of organelle contact sites, and the rapid and reversible reconstitution of inter-organelle tethers that have key regulatory function in lipid transport. Thu, 31 Dec 2020 04:00:00 Z