Karina Zielinski
About
Research
Publications
2024
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers
Gray M, Zielinski K, Xu F, Elder K, McKay S, Ojo V, Benjamin S, Yaseen A, Brooks T, Tumey L. A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin-cleavable ADC linkers. Xenobiotica 2024, 54: 458-468. PMID: 38738708, PMCID: PMC11436314, DOI: 10.1080/00498254.2024.2352051.Peer-Reviewed Original ResearchConceptsAntibody-drug conjugatesSafety of antibody-drug conjugatesTumor microenvironment dynamicsDrug delivery technologySpecific cell typesLegumain expressionMonoclonal antibodiesTherapeutic payloadsDelivery technologiesMicroenvironment dynamicsCell typesTumorEfficacyLysosomal stabilityLinker technology