Biostatistics Core
The primary objective of the Biostatistics Core is to provide state-of-the-art design and analytical services to investigators conducting studies that advance the Yale OAIC theme of multifactorial geriatric conditions.
The Biostatistics Core consists of faculty and staff that aim to:
- Collaborate with Pepper Scholars, Pilot and Exploratory Core investigators, the Operations Core, and investigators of external projects to achieve the mission of the Yale OAIC in promoting the understanding and treatment of multifactorial geriatric conditions
- Develop new and sound methods that address the challenges of designing and analyzing studies in basic, translational, and clinical geriatric/aging research, with special emphasis on introducing statistical methods from other disciplines
- Train the next generation of statisticians, epidemiologists and junior investigators in Gerontologic Biostatistics research methods specific to studies of multifactorial geriatric health conditions
Statistical and Analytical Services
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Biostatisticians in the core can assist with analysis and design at all stages of a project from early stages of grant development (statistical methodology, power analyses) to manuscript preparation.
Collaborators
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We coordinate services regularly within the Yale research community:
Publications
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- A single near-infrared light-triggered nanoplatform based on upconversion nanoparticles for synergistic photodynamic/photothermal therapy.Pang T, Xie X, Feng G, Zheng S, Li Z, Li J, Shu W, Peng D, Jian X, Han L, Zhang M. Spectrochim Acta A Mol Biomol Spectrosc. 2026 Aug 5; 2026 Feb 20. PMID: 41863217.
- An integrated quality evaluation strategy combining chemical fingerprinting, chemometrics, network pharmacology, and spectrum-effect relationship for optimizing the harvest time and post-harvest processing of Clematidis Radix et Rhizoma.Dong S, Lin Y, Li Q, Han Y, Shao P, Han L, Yu Y, Lv C, Lu J. J Chromatogr B Analyt Technol Biomed Life Sci. 2026 Jun 1; 2026 Apr 3. PMID: 41999710.
- The neuroprotective effect of guanabenz combined with α-lipoic acid in the hSOD1-G93A amyotrophic lateral sclerosis model.Zhang W, Zhang D, Han L, Wang D, Huo D, Tan X, Su X, Wang M, Xu J, Cheng J, Feng H. Brain Res Bull. 2026 Jun 1; 2026 Apr 15. PMID: 41991114.
- Identification of a critical medication trajectory for depression risk in hypertension: A nationwide dual-cohort longitudinal study in china.Zeng C, Jie B, Zhang J, Tao L, Wang Y, Mei Z, Han L. Psychiatry Res. 2026 Jun; 2026 Mar 9. PMID: 41831294.
- Trajectories of cognitive performance in the six months after hospitalization with COVID-19 among community-dwelling older adults.Li J, McAvay G, Kaminski TA, Gill TM, Cohen AB, Ferrante LE, Hajduk AM. J Gerontol A Biol Sci Med Sci. 2026 May 11; 2026 May 11. PMID: 42112607.
- Days Alive and at Home After Critical Illness Hospitalization Among Older Adults and Its Association With Delivery of In-Hospital Rehabilitation.Kim S, Murphy TE, O'Leary JR Jr, Leo-Summers L, Falvey JR, Gill TM, Krumholz HM, Ferrante LE, Jain S. Crit Care Med. 2026 May 1; 2026 Mar 10. PMID: 41805229.
- The Veteran Affairs' Whole Health Approach for Chronic Pain Management: The wHOPE Randomized Clinical Trial.Seal KH, Morasco BJ, Martin AM, Reddy KP, Van Iseghem TM, Bolton RE, Bokhour BG, Murphy J, Denneson LM, Esserman D, Buta E, Purcell N, Bertenthal D, Painter JT, Abadjian LR, Moore LC, Chan AC, McCamish N, Maguen S, Neylan TC, Gibson CJ, Becker WC. JAMA. 2026 Apr 29; 2026 Apr 29. PMID: 42054020.
- Micro-Doppler Radar Identifies Movement Asymmetries After Anterior Cruciate Ligament Reconstruction.Onks CA, Zeng C, Creath RA, Simone BD, Nyland JE, Murphy TE, Kishel LA, Ardat B, Venezia VA, Wiggins AM, Shaffer BR, Narayanan RM. medRxiv. 2026 Apr 21; 2026 Apr 21. PMID: 42078348.
- Xuming Zhusan Decoction Attenuates Post-Stroke via Modulating TLR4/MYD88/NF-κB Pathway in Mice.Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z, Fei X, Peng M, Zhou J, Zhong Z. Food Sci Nutr. 2026 Apr; 2026 Apr 16. PMID: 42005317.
- A Diagnostic Dilemma of Arrhythmogenic Cardiomyopathy Masquerading as Recurrent Myocarditis in a Pediatric Patient with a DES Gene Variant: A Case Report.Meng Q, Li W, Ding W, Wang H, Chen D, Han L, Li Y, Dai C. J Cardiovasc Dev Dis. 2026 Apr 8; 2026 Apr 8. PMID: 42041988.
- SYHX1901, an oral dual Janus kinase and spleen tyrosine kinase inhibitor, for moderate-to-severe plaque psoriasis: A randomized phase 2 trial.Han L, Zhu L, Yu G, Cheng F, Cao L, Pei Z, Qin X, Mou K, Zhang S, Liang X, Li S, Ding Y, Zhu Q, Shi C, Man X, Kang X, Zhang F, Wu S, Xu J. J Am Acad Dermatol. 2026 Apr; 2025 Dec 17. PMID: 41419128.
- Comparison of short-axis and oblique-axis approaches for ultrasound-guided right internal jugular vein cannulation in the left decubitus position: a randomized clinical trial study protocol.Liu W, Su Z, Yi M, Han L, Zhou J, Zhang J. Trials. 2026 Mar 24; 2026 Mar 24. PMID: 41877262.
- Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis in Rats After Stroke by Activating the NRF2/GPX4/SLC7A11 Pathway.Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z, Fei X, Peng M, Zhou J, Zhong Z. Food Sci Nutr. 2026 Mar; 2026 Mar 10. PMID: 41822239.
- Moisture-Proof Herbal Extract Pellets Prepared via Asymmetric Liquid Layering Technology Combined with Mesoporous Silica and Magnesium Stearate.Ma S, Feng Y, Yuan P, Xu Y, Shao P, Lin L, Wang Z, Han L, Tang X. AAPS PharmSciTech. 2026 Mar 10; 2026 Mar 10. PMID: 41807885.
- Days at Home After Serious Health Events Among Community-Living Older Persons.Gill TM, Leo-Summers L, Gahbauer EA, Becher RD, Ferrante LE, Han L. J Am Geriatr Soc. 2026 Mar 10; 2026 Mar 10. PMID: 41807297.
- Rethinking immune studies: population-level immune variations and the path forward.Hysong MR, Memili A, Delaney JA, Ekunwe L, Huber S, Reiner AP, Patsy BM, Sitlani CM, Tracy RP, Taylor KD, Olson NC, Doyle MF, Raffield LM. J Gerontol A Biol Sci Med Sci. 2026 Mar 10. PMID: 41741349.
- [A Comprehensive Comparative Analysis of Land Use Change Prediction Models Based on Land Types].Qu SJ, Han L, Li LZ. Huan Jing Ke Xue. 2026 Mar 8. PMID: 41830258.
- Anodal high-definition transcranial direct current stimulation reveals a specific role for posterior parietal cortex in interlimb generalization.Dexheimer B, Kitchen NM, Murphy TE, Yuk J, Yarossi M, Tunik E, Sainburg RL. Cereb Cortex. 2026 Mar 3. PMID: 41843804.
- A case description: lymphangioleiomyomatosis mimicking ovarian cyst.Han L, Luo G, Xuan Z, Ruan J. Quant Imaging Med Surg. 2026 Mar 1; 2026 Feb 6. PMID: 41816061.
- Cardiac Rehabilitation Utilization Among Veterans: A Sex-Based Analysis.Varghese MS, Han L, Gandhi PU, Skanderson M, Wu WC, Drwal KR, Burg MM, Kazi DS, Gaffey AE, Levy DR, Feder S, Bean Mayberry BA, Farmer MM, Mattocks KM, Brandt CA, Bastian LA, Akgün KM. JACC Adv. 2026 Mar; 2026 Feb 18. PMID: 41713154.
- Targeted Remediation of the Ipsilesional Arm in Chronic Stroke: A Randomized Clinical Trial.Maenza C, Winstein CJ, Murphy TE, Kitchen NM, Tanaka J, Yuk J, Varghese R, Sainburg RL. JAMA Neurol. 2026 Mar 1. PMID: 41627841.
- Study on the expression level of folate receptor γ in thyroid cancer and its association with clinicopathological characteristics.Cao J, Li Y, Deng X, Lv B, Han L, Tong L. Oncol Lett. 2026 Mar; 2026 Jan 12. PMID: 41586021.
- Impact of the 2015 Dutch Long-Term Care Reform on Nursing Home Use and Access for People With Dementia.Wammes JD, Wouterse B, Murphy TE, MacNeil Vroomen JL. J Am Geriatr Soc. 2026 Mar; 2026 Jan 22. PMID: 41568552.
- Circulating immune cell phenotypes are associated with inflammatory biomarkers in dementia-free participants from the Framingham Heart Study Offspring cohort.Chen J, Doyle MF, Cao Y, Iyer S, Ragab AAY, Murabito JM, Lunetta KL. Sci Rep. 2026 Feb 27; 2026 Feb 27. PMID: 41760714.
- Methods and applications of patient-derived organoid models for immune microenvironment and immunotherapy research in multiple cancer types.Yu Y, Li Y, Wang J, Zhu Y, Zhang Z, Xiao Z, Chen Y, Qu Y, Han L, Zhang H. Exp Hematol Oncol. 2026 Feb 13; 2026 Feb 13. PMID: 41689064.
- A Cluster Randomized Trial of a Vaccination Communication Educational Intervention: Impact on COVID-19 Vaccine Uptake in Veterans.Seal KH, Kaplan A, Manuel JK, Bertenthal D, Purcell N, DeRonne BM, Oliver KA, Esserman D, McCamish N, Mesidor M, Griffin B, Borsari B, Woodruff NA, Usman H, Pyne JM. J Gen Intern Med. 2026 Feb 12; 2026 Feb 12. PMID: 41680545.
- Relationships Between Circulating Lipids, Lipoproteins, and Lymphocyte Subsets in the Multi-Ethnic Study of Atherosclerosis.DeConne TM, Sitlani CM, Delaney JA, Psaty BM, Doyle MF, Otvos JD, Feinstein MJ, Olson NC. Glob Heart. 2026; 2026 Feb 3. PMID: 41660200.
- Experiences of People Who Discontinue Long-Acting Injectable Buprenorphine Treatment Recently Released From Prison in New South Wales, Australia.Peck LJD, White B, Moensted M, Doyle MF, McEntyre E, Pazeski A, Lawson S, Roberts J, Haber PS, Lintzeris N, Dunlop AJ, Maher L. Drug Alcohol Rev. 2026 Feb. PMID: 41709525.
- Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.Machavariani E, Esserman D, Dumchev K, Filippovych M, Pykalo I, Ivasiy R, Madden LM, Bromberg DJ, Haddad M, Morozova O, Oliveros D, Ahmad B, Dvoriak S, Altice FL. Ann Intern Med. 2026 Feb; 2025 Dec 9. PMID: 41359964.
- Association of circulating immune cell phenotypes and peripheral inflammatory biomarkers with depressive symptoms in the Framingham Heart Study.Iyer S, Cao Y, Liebegott R, Chen J, Ragab A, Doyle MF, Lunetta KL, Murabito JM. Psychoneuroendocrinology. 2026 Feb; 2025 Dec 2. PMID: 41349492.
- A SAS macro for multilevel Cosinor analysis.Doyle MM, Murphy TE, Miner B, Knauert MP. Comput Methods Programs Biomed. 2026 Feb 1; 2025 Nov 14. PMID: 41297072.
- Chronic Pain Locations, Characteristics, and Associations With Other Symptoms in Adults Receiving Maintenance Hemodialysis: Findings From the HOPE Consortium Trial.Fischer MJ, Hsu JY, Walsh J, Cavanaugh KL, Charytan DM, Crowley ST, Cukor D, Dember LM, Doorenbos AZ, Esserman D, Jhamb M, Johansen KL, Keefe FJ, Kimmel PL, Lockwood MB, Mehrotra R, Morasco BJ, Nigwekar S, Pun P, Qamhiyeh R, Scherer JS, Schmidt R, Steel JL, Unruh ML, Yabes JG, Kalim S. Am J Kidney Dis. 2026 Feb; 2025 Nov 17. PMID: 41238165.
- Glycolipid recognition and binding by Siglec-6 hinges on interactions with the cell membrane.D'Andrea S, Schmidt EN, Bui D, Singh O, Han L, Mahal LK, Klassen JS, Macauley MS, Fadda E. Commun Biol. 2026 Jan 28; 2026 Jan 28. PMID: 41606261.
- Identifying 2PHDO as a SOCE Inhibitor from Chinese Herbal Extracts.Liu J, Deng H, Li Y, Du Y, Wang L, Wang Y, Liu J, Xi C, Gao P, Zhou Y, Han L, Gill DL, Lu C, Wang Y. Curr Pharm Biotechnol. 2026 Jan 28; 2026 Jan 28. PMID: 37317920.
- Cross-ancestry comparison of aptamer and antibody protein measures.Nicholas JC, Katz DH, Tahir UA, Debban CL, Aguet F, Blackwell T, Bowler RP, Broadaway KA, Chen J, Clish CB, Coresh J, Cornell E, Cruz DE, Deo R, Doyle MF, Durda P, Ekunwe L, Floyd JS, Gill D, Guo X, Hoogeveen RC, Johnson C, Lange LA, Li Y, Manning A, Meigs JB, Mi MY, Mychaleckyj JC, Olson NC, Pratte KA, Psaty BM, Reiner AP, Ruan P, Sevilla-Gonzalez M, Shah AM, Sun Q, Tracy RP, Wen J, Wood AC, Wilson JG, Young KL, Yu B, Rooney MR, Manichaikul A, Dubin R, Mohlke KL, Rich SS, Rotter JI, Ganz P, Gerszten RE, Taylor KD, Raffield LM. Nat Commun. 2026 Jan 22; 2026 Jan 22. PMID: 41571639.
- Fertility preservation in transgender youth from initial counseling through preservation procedures: A retrospective cross-sectional study.Petriceks AC, Maheshwari C, Murphy TE, Butts S, Roden RC. J Pediatr Adolesc Gynecol. 2026 Jan 20; 2026 Jan 20. PMID: 41571225.
- Multi-omics data improves one-year mortality prediction in acute heart failure.Li X, Jia Y, Wang F, Jie B, Sha P, Chen L, Zhao Y, Liang H, Li X, Du Y, Hong B, Han L. Clin Chim Acta. 2026 Jan 15; 2025 Oct 17. PMID: 41109397.
- Body mass index and chemotherapy completion among patients with newly diagnosed ovarian cancer.Cao A, Cartmel B, Ratner E, Li FY, Schlumbrecht MP, Kumar A, Crane TE, Esserman DA, Irwin ML, Ferrucci LM. JNCI Cancer Spectr. 2026 Jan 9. PMID: 41442446.
- Correction: High-temperature and solid-state NMR investigation of the structural evolution and special phase transition in LiF-NaF-BeF(2) mixed salts.Sun J, Huang H, Han L, Fu X, Liu H, Qian Y. Phys Chem Chem Phys. 2026 Jan 7; 2026 Jan 7. PMID: 41355711.
- Huang-qin decoction increases the sensitivity of EGFR-TKIs to NSCLC cells by regulating stat3/GPX4 to induce redox ratio and ROS to inhibit CSCs.Yu Y, Lei C, Li Y, Ma C, Ding L, Xiao Z, Tang Q, Chen Y, Jiang R, Su Y, Han L, Zhu Y, Zhang H. J Tradit Complement Med. 2026 Jan; 2025 Feb 7. PMID: 41696740.
- Associations between Social Determinants of Health and Posthospitalization Rehabilitation among Critically Ill Older Adults.Jain S, Murphy TE, Falvey JR, Leo-Summers L, Zang E, Gill TM, Krumholz HM, Ferrante LE. Ann Am Thorac Soc. 2026 Jan 1. PMID: 41025933.
- The Importance of Geriatric Emergency Department Assessments: Recognizing Patient Risks and Value of Data in Research-A Reply.Hwang U, Cohen I, Carpenter C, Han L, Hung W. Acad Emerg Med. 2026 Jan; 2025 Aug 28. PMID: 40875581.
- The Geriatric Emergency Care Applied Research Standardization Study (GEARSS): An Observational Study of Older Emergency Department Patients.Hwang U, Sifnugel N, Cohen I, Han L, Araujo K, Bianco LM, Brandt CA, Capelli S, Carpenter CR, Cruz DS, Dresden SM, Fishman IL, Gipson K, Hastings SN, Hung WW, Kang R, Lockhart M, Meeker D, Ohuabunwa U, Ottilie-Kovelman S, Partridge C, Platts-Mills TF, Sandoval J, Taylor Z, Tomasino DF, Vaughan CP. Acad Emerg Med. 2026 Jan; 2025 Jul 12. PMID: 40650481.
- MTHFR allele and one-carbon metabolic profile predict severity of COVID-19.Petrova B, Syphurs C, Culhane AJ, Chen J, Chen E, Cotsapas C, Esserman D, Montgomery RR, Kleinstein SH, Smolen KK, Mendez K, Lasky-Su J, Steen H, Levy O, Diray-Arce J, Kanarek N. Proc Natl Acad Sci U S A. 2025 Dec 23; 2025 Dec 18. PMID: 41410771.
- Factors contributing to COVID-19 vaccine hesitancy in Veterans later in the pandemic.Pyne JM, Seal KH, Manuel JK, Kaplan AN, Purcell N, Bertenthal D, Esserman D, Mesidor M, DeRonne BM, Oliver KA, Griffin BJ, Simpson H, Woodruff N, Borsari B, Tobey-Moore L, Usman H. BMC Public Health. 2025 Dec 19; 2025 Dec 19. PMID: 41413473.
- Global burden of head and neck cancers including thyroid cancer in older adults (≥ 60 years old) and projections to 2050: a systematic and comprehensive analysis of the global burden of disease study 2021.Li X, Du Z, Tan W, Wu S, Wang C, Pan Y, Han F, Wang G, Xie W, Zhu M, Han L, Zhang X, Zhou Q. BMC Geriatr. 2025 Dec 16; 2025 Dec 16. PMID: 41402746.
- Approach to Quality Control Used for the HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis.Nigwekar SU, Dember LM, Kalim S, Charytan DM, Kuzla N, Kimmel PL, Cukor D, Esserman D, Mishra P, Silva K, Steffen AD, Vassilieva S, Williams J, Wetmore JB. Clin J Am Soc Nephrol. 2025 Dec 2; 2025 Dec 2. PMID: 41414940.
- [Development status and issues of traditional Chinese medicine preparations in medical institutions].Liu Y, Zhang J, Li SY, Lu Y, Dong ZQ, Li G, Tian JX, Han L, Yan ZF, Shen N, Liu A. Zhongguo Zhong Yao Za Zhi. 2025 Dec. PMID: 41814714.
- Artificial Intelligence and Clinical Care: JAMA Internal Medicine Call for Papers.Gross CP, Richman IB, Stall NM, Kneifati-Hayek JZ, Allore HG, Rittenberg E, Katz MH, Grady D, Durant RW, Anderson TS, Tripodis Y, Wang TY, Corbie G, Mody L, Perlis RH, Ganguli I, Inouye SK. JAMA Intern Med. 2025 Dec 1. PMID: 41082189.
- A Multicenter Validation of a Fully Automated Chemiluminescence Immunoassay for Plasma Elafin in Psoriasis Diagnosis and Severity Assessment.Yi J, Xu M, Han L, Dong Z, Liu R, Zhang X, Hu D, Lu C, Yu X. Adv Sci (Weinh). 2025 Dec; 2025 Sep 30. PMID: 41028930.
- Explainable artificial intelligence predicts inflammatory and spatial heterogeneity from nasal polyp histology.Wang K, Ren Y, Ma L, Han L, Xu L, Guan H, Cui Y, Wu L, Liu C, Liu W, Wang J, Liu H, Fan Y, Shi J, Sun Y. J Allergy Clin Immunol. 2025 Dec; 2025 Sep 2. PMID: 40902945.
- Spatial and temporal variations in grassland aboveground biomass and their drivers in central Inner Mongolia, China.Zhang SL, Wu TJ, Han L, Wang LH, Sun HL. Ying Yong Sheng Tai Xue Bao. 2025 Nov 18. PMID: 41392667.
- Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc(-) and miR-214-3p/Stat3/GPX4 axis.Shi Y, Ma C, Tang X, Su H, Lu Y, Wei J, Li L, Huang T, Wang X, Qin X, Ding Y, Han L, Wu J. Front Immunol. 2025; 2025 Nov 18. PMID: 41341590.
- A polysaccharide smart packaging materials: Anthocyanin microcapsules synergized with nanosilver co-filled gellan gum/sodium alginate film for monitoring chilled mutton freshness.Song Z, Ni W, Zheng Y, Ma Y, Cao Y, Han L, Yu Q. Carbohydr Polym. 2025 Nov 15; 2025 Aug 11. PMID: 40947273.
- Clinical-genetic profiles and risk prediction model in childhood restrictive cardiomyopathy: a national cohort study of China.Chen H, Wang S, Quan J, Ding W, Liu C, Peng H, Wang J, Xiao Y, Li Z, Wang H, Gao L, Shi L, Li Y, Yang S, Zhang L, Huang Y, Liang P, Guo Q, Li J, Shan G, Zhang H, Liu X, Zhang H, Li W, Zhang B, Zhang C, Tong S, Chan W, Wang R, Zhang H, Han L, Lv T, Fu L. BMC Med. 2025 Nov 11; 2025 Nov 11. PMID: 41219744.
- PSORI-CM02 Restores Epidermal Differentiation in Psoriasis via the Gut Microbiota-Sphingolipid Axis.Wu Y, Pan S, Yin C, Kong Y, Huo W, Wang Q, Wu J, Li L, Wei J, Lu C, Han L, Lu Y. Drug Des Devel Ther. 2025; 2025 Nov 7. PMID: 41235136.
- A Pan-Cancer Analysis of the Oncogenic Role of YES Proto-Oncogene 1 (YES1) in Human Tumors.Dou R, Han L, Liu G, Zhu X, Yang Z, Hu P, Su Y. J Gene Med. 2025 Nov. PMID: 41287103.
- Production of human cathepsins using Expi293™ mammalian cell expression system for off-target activity of cysteine protease inhibitor screening.Turner Z, Arutyunova E, Bui DT, Han L, Kandadai AS, Bai B, Young HS, Mahal LK, Klassen JS, Lemieux MJ. Protein Sci. 2025 Nov. PMID: 41147856.
- Sacituzumab govitecan in Chinese patients with recurrent/metastatic cervical cancer: Results from the phase 2 EVER-132-003 basket study (NCT05119907).An J, Li G, Zhang Y, Feng M, Kong W, Jiang H, Luo S, Li W, Xu C, Han L, Chen Y, Mocci S, Yan Y, Wu L. Gynecol Oncol. 2025 Nov; 2025 Sep 18. PMID: 40972504.
- Comprehensive insights into the effect of color, texture, flavor and microbial community driven via yak bone-derived collagen peptides combined with tea polyphenols as a versatile additive in fermented sausages.Song Z, Zheng Y, Ma Y, Ni W, Cao Y, Han L, Yu Q. Food Res Int. 2025 Nov; 2025 Jul 11. PMID: 40922223.
- Erratum to "A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44(+) CD24- enriched breast cancer stem-like cells" [Drug Resist. Updates 66 (2023) 100903].Liu C, Zhang Y, Gao J, Zhang Q, Sun L, Ma Q, Qiao X, Li X, Liu J, Bu J, Zhang Z, Han L, Zhao D, Yang Y. Drug Resist Updat. 2025 Nov; 2025 Sep 4. PMID: 40912935.
- Sequentially Constrained Randomization in Preclinical Animal Studies.Rigdon J, Walkup M, Amar D, Wheeler MT, Goodyear LJ, Bodine S, Esser K, Esserman D, Miller ME. Function (Oxf). 2025 Oct 28. PMID: 41059916.
- Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation.Zhang D, Han L, Zhang W, Wang D, Huo D, Tan X, Su X, Wang M, Xu J, Cheng J, Wang J, Feng H. Front Pharmacol. 2025; 2025 Oct 27. PMID: 41221045.
- Platelet Hyperactivation Plays a Critical Role in Exacerbating Skin Lesions in Rats with Psoriasis and Blood Stasis Syndrome.Yue H, Mo H, Su H, Zeng Z, Liu F, Lei C, Sun Y, Wang T, Pi X, Li L, Wu J, Han L. J Inflamm Res. 2025; 2025 Oct 27. PMID: 41181363.
- Neighborhood Deprivation and Symptom Burden Among Older Adults After Hospitalization for COVID-19.Falvey JR, Acampora D, Araujo K, Geda M, Gill TM, McAvay G, Murphy TE, Hajduk A, Cohen AB, Ferrante LE. J Appl Gerontol. 2025 Oct 27; 2025 Oct 27. PMID: 41145178.
- Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response.Mach J, Blaker CL, Winters B, Otsu Y, Clarke EC, Allore H, Wyk BV, Winardi K, Peel R, Gregson CW, Assareh N, Kourieh M, Hilmer SN. bioRxiv. 2025 Oct 23; 2025 Oct 23. PMID: 41279379.
- Disparities in Geographic Access to Cardiac Rehabilitation Among Socially Vulnerable Communities.Chen EW, Wu WC, Han L, Gandhi PU, Bastian LA, Brandt CA, Mattocks KM, Oen-Hsiao J, Varghese MS. J Am Heart Assoc. 2025 Oct 21; 2025 Oct 9. PMID: 41065247.
- Efficacy and Blood Concentrations of Cetuximab in a Hemodialysis Patient with Tongue Squamous Cell Carcinoma: A Case Report.Niu TT, Zhang WY, Han L, Shi HJ, Piao Y, Ren LW, Wu SH. Case Rep Oncol. 2025 Jan-Dec; 2025 Oct 16. PMID: 41323038.
- Correction: Influences of environmental and leaf functional traits variations on photosynthetic characteristics of Cotoneaster multiflorus in Xinglong Mountain.Han L, Ma X, Zhao C, Liu D. Front Plant Sci. 2025; 2025 Oct 8. PMID: 41140383.
- Intermedin Inhibits DNA Damage-Promoted Senescent Phenotype Transition of Vascular Smooth Muscle Cells in Aorta by Activating NAMPT/PARP1 in Mice.Ji DR, Chen Y, Zhu HX, Liu SM, Wu N, Zhang YR, Zhao J, Yu YR, Jia MZ, Han L, Tang CS, Chen LL, Zhou YB, Qi YF. Pharmaceuticals (Basel). 2025 Oct 7; 2025 Oct 7. PMID: 41155618.
- Associations of Immune Cell Subsets With Coronary Artery Calcium Incidence and Progression in the Multi-Ethnic Study of Atherosclerosis.Patel RD, Buzkova P, Huber S, Landay A, Budoff M, Bis JC, Olson N, Rich S, Heckbert SR, Manichaikul A, Floyd J, Tracy RP, Psaty BM, Doyle MF, Sitlani CM, Delaney JAC, Fohner AE, Feinstein MJ. J Am Heart Assoc. 2025 Oct 7; 2025 Sep 19. PMID: 40970536.
- Trends in State Palliative Care Legislation Across the US.Ouyang N, Han L, Jiang W, Sinclair S, Rusyn E, Feder SL. JAMA Health Forum. 2025 Oct 3; 2025 Oct 3. PMID: 41134560.
- Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort.Rotti L, Murabito JM, Chen J, Cao Y, Ragab AAY, Liu C, Wang M, Doyle MF, Lunetta KL. Geroscience. 2025 Oct 2; 2025 Oct 2. PMID: 41039184.
- Reply to: Reevaluating Functional Recovery Post-COVID-19: A Call for Broader Considerations.Ho JQ, McAvay GJ, Murphy TE, Acampora D, Araujo K, Geda M, Gill TM, Hajduk AM, Cohen AB, Ferrante LE. J Am Geriatr Soc. 2025 Oct; 2025 May 20. PMID: 40390544.
- Current and Future Projection of Scrub Typhus Risk Related to Land Use Change in China.Han L, Sun Z, Zhang G, Zhang Y, Ren H, Teng Z, Xu J, Qin T. Geohealth. 2025 Sep; 2025 Sep 14. PMID: 40959768.
- [Analysis, Evaluation, and Prediction Model of Water Quality in the Weihe River Basin].Zhang JX, Cai QW, Kang ZY, Cong M, Han L, He JJ, Yang LW. Huan Jing Ke Xue. 2025 Sep 8. PMID: 40962755.
- Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study.Ragab AAY, Doyle MF, Chen J, Lunetta KL, Murabito JM. Alcohol Clin Exp Res (Hoboken). 2025 Sep; 2025 Jul 29. PMID: 40728111.
- DAPK1 induces motor neuron apoptosis in hSOD1(G93A)-linked amyotrophic lateral sclerosis via regulating the Xiap/JNK pathway.Su X, Tan X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Feng H. Mol Cell Neurosci. 2025 Sep; 2025 Jul 14. PMID: 40669676.
- Health-related social needs before and after critical illness among Medicare beneficiaries.Kaminski TA, Murphy TE, O'Leary JR, Leo-Summers L, Ferrante LE. J Gerontol B Psychol Sci Soc Sci. 2025 Aug 23. PMID: 40587086.
- COMM domain containing 4 inhibits hephaestin and ferroportin to enhance neuronal ferroptosis by disturbing the Cu-Fe balance in amyotrophic lateral sclerosis.Tan X, Su X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Wang S, Wang J, Feng H. Brain Res. 2025 Aug 15; 2025 May 17. PMID: 40389143.
- Influences of environmental and leaf functional traits variations on photosynthetic characteristics of Cotoneaster multiflorus in Xinglong Mountain.Ma X, Han L, Zhao C, Liu D. Front Plant Sci. 2025; 2025 Aug 5. PMID: 40838082.
- Recurrent and rapidly growing vaginal wall leiomyoma during pregnancy: a case description.Han L, Shi G, Zheng A, Ruan J. Quant Imaging Med Surg. 2025 Aug 1; 2025 Jul 30. PMID: 40785872.
- Laparoscopic Management of Neonatal Ovarian Torsion.Han L, Shi G, Zheng A, Ruan J. J Minim Invasive Gynecol. 2025 Aug; 2024 Dec 16. PMID: 39694440.
- Agreement Between Self-Reported and Proxy-Reported Pain in Veterans With Advanced Heart Failure.Akgün KM, Han L, Zhan Y, Abel EA, Feder SL. Am J Hosp Palliat Care. 2025 Jul 31; 2025 Jul 31. PMID: 40741915.
- Analysis of serum metabolomics in patients with different types of chronic heart failure.Jie B, Li Q, Han L, Chen L, Yang M. Open Med (Wars). 2025; 2025 Jul 23. PMID: 40718801.
- Fall Risk in Maintenance Hemodialysis Patients: A Secondary Analysis of the HOPE Consortium Trial.Charytan DM, Moss AH, Shalak M, Wu W, Dember LM, Hsu JY, Kuzla N, Esserman D, Kalim S, Kimmel PL, Lockwood MB, Miyawaki N, Pellegrino B, Pun PH, Qamhiyeh R, Scherer J, Schrauben S, Weiner DE, Mehrotra R. Clin J Am Soc Nephrol. 2025 Jul 15; 2025 Jul 15. PMID: 40663732.
- Longitudinal sequencing of cardiometabolic multimorbidity among older adults and association with subsequent dementia onset.Nagel CL, Chen S, Allore HG, Botoseneanu A, Newsom JT, Bishop N, Dorr DA, Kaye J, Quiñones AR. PLoS One. 2025; 2025 Jul 10. PMID: 40638618.
- Single-cell spatial transcriptome atlas and whole-brain connectivity of the macaque claustrum.Lei Y, Liu Y, Wang M, Yuan N, Hou Y, Ding L, Zhu Z, Wu Z, Li C, Zheng M, Zhang R, Ribeiro Gomes AR, Xu Y, Luo Z, Liu Z, Chai Q, Misery P, Zhong Y, Song X, Lamy C, Cui W, Yu Q, Fang J, An Y, Tian Y, Liu Y, Sun X, Wang R, Li H, Song J, Tan X, Wang H, Wang S, Han L, Zhang Y, Li S, Wang K, Wang G, Zhou W, Liu J, Yu C, Zhang S, Chang L, Toplanaj D, Chen M, Liu J, Zhao Y, Ren B, Shi H, Zhang H, Yan H, Ma J, Wang L, Li Y, Zuo Y, Lu L, Gu L, Li S, Wang Y, He Y, Li S, Zhang Q, Lu Y, Dou Y, Liu Y, Zhao A, Zhang M, Zhang X, Xia Y, Zhang W, Cao H, Lu Z, Yu Z, Li X, Wang X, Liang Z, Xu S, Liu C, Zheng C, Xu C, Liu Z, Li C, Sun YG, Xu X, Dehay C, Vezoli J, Poo MM, Yao J, Liu L, Wei W, Kennedy H, Shen Z. Cell. 2025 Jul 10; 2025 Apr 3. PMID: 40185102.
- A New Insight Into the Structure-Activity Relationship of Antifreeze Activity in Bovine Hide Collagen Peptides: Based on Molecular Weight Differences.Zhang Y, Wang X, Jia P, Wang Y, Zhang L, Yu Q, Han L. J Food Sci. 2025 Jul. PMID: 40610213.
- YouTube and Bilibili as sources of information on oral cancer: cross-sectional content analysis study.Zhang Q, Li Z, Zhang H, Han L, Zhao S, Jia S. Sci Rep. 2025 Jul 1; 2025 Jul 1. PMID: 40593960.
- Assessing the impacts of climate anomalies on plague risk in China during 1754-1949.Zhao Y, Sun Z, An X, Zhang S, Gong S, Chen D, Che H, Han L, Zhang G, Zhu D, Hou Q, Li Y, Tong S. Environ Int. 2025 Jul; 2025 May 26. PMID: 40472758.
- The Longitudinal Course of Physical Activity Behavior Poststroke and Its Variation Across Subgroups: The Norwegian Cognitive Impairment After Stroke Study.Luzum G, Allore H, Han L, Saltvedt I, Tan X, Thingstad P, Håberg A, Askim T. Phys Ther. 2025 Jul 1. PMID: 40360170.
- Upholding Our Duty to Care for Undocumented Immigrants.Gross CP, Richman IB, Ganguli I, Anderson TS, Rittenberg E, Stall NM, Kneifati-Hayek JZ, Durant RW, Grady D, Allore HG, Corbie G, Inouye SK. JAMA Intern Med. 2025 Jul 1. PMID: 40354074.
- Quantifying Protein-Glycan Interactions Using Native Mass Spectrometry.Bui DT, Kitova EN, Han L, Mahal LK, Klassen JS. Mass Spectrom Rev. 2025 Jun 30; 2025 Jun 30. PMID: 40583568.
- Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study.Fang Y, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Doyle MF, Murabito JM, Lunetta KL. Front Aging Neurosci. 2025; 2025 Jun 25. PMID: 40636900.
- Social Support and Social Strain Sources as Predictors of Multimorbidity Changes in Middle-Aged and Older Adults.Newsom JT, Saucedo J, Kroeck MR, O'Neill AS, Allore HG, Nagel CL, Botoseneanu A, Trubits EF, Dorr DA, Quiñones AR. J Aging Health. 2025 Jun 25; 2025 Jun 25. PMID: 40557788.
- Dissolution of zero-valent Al and its structural transformation in chloride molten salts.Yingsu J, Liu Y, Sun J, Huang H, Han L, Ge M, Fu X, Qian Y, Liu H. Dalton Trans. 2025 Jun 10; 2025 Jun 10. PMID: 40384392.
- Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study.Dobrota Lai S, Buzkova P, Delaney JA, Olson NC, Psaty BM, Huber SA, Doyle MF, Tracy RP, Odden MC. J Gerontol A Biol Sci Med Sci. 2025 Jun 10. PMID: 40378276.
- [Construction and evaluation of a cell model simulating the change of testicular microenvironment mediated by hypoxic and high-pressure conditions in varicocele mice].Liang SL, Geng LG, Han L, Rong CN, Qin Z, DU J, He CB, Yuan SY. Zhonghua Nan Ke Xue. 2025 Jun. PMID: 40788238.
- [Expert consensus on evaluation index system construction for new traditional Chinese medicine(TCM) from TCM clinical practice in medical institutions].Liu L, Zhang L, Yuan WA, Yang ZQ, Zhang JH, Wang BH, Hu SY, Ye ZG, Han L, Zhou YH, Yang ZF, Gao R, Yang M, Wang T, Xia JL, Yu SS, Fan XH, Hua H, He J, Lu Y, Wang Z, Dou JH, Li G, Dong Y, Yu H, Qu LP, Tang JY. Zhongguo Zhong Yao Za Zhi. 2025 Jun. PMID: 40686129.
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