Jean-Dominique Gallezot, PhD
Research Scientist in Radiology and Biomedical ImagingDownloadHi-Res Photo
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Radiology & Biomedical Imaging
PO Box 208042
New Haven, CT 06520-8042
United States
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Titles
Research Scientist in Radiology and Biomedical Imaging
Appointments
Radiology & Biomedical Imaging
Research ScientistPrimary
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Education & Training
- PhD
- Universite Pierre et Marie Curie, Neuroscience (2006)
- MS
- Université Pierre et Marie Curie, Neuroscience (2002)
- ME
- École Supérieure d'Électricité, Digital Telecommunications (2002)
- BS
- Ecole Polytechnique, Physics (2000)
Research
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Overview
Medical Research Interests
Brain; Data Analysis; Imaging, Three-Dimensional; Molecular Imaging; Positron-Emission Tomography; Receptors, Neurotransmitter; Whole Body Imaging
ORCID
0000-0003-0399-8374
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jean-Dominique Gallezot's published research.
Publications Timeline
A big-picture view of Jean-Dominique Gallezot's research output by year.
Research Interests
Research topics Jean-Dominique Gallezot is interested in exploring.
Richard Carson, PhD
Nabeel Nabulsi, PhD
David Matuskey, MD
Mika Naganawa, PhD
Chi Liu, PhD
Mike Ming-Qiang Wenn
136Publications
6,028Citations
Positron-Emission Tomography
Brain
Molecular Imaging
Imaging, Three-Dimensional
Whole Body Imaging
Publications
2026
Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction
Gravel P, Gallezot J, Fontaine K, Matuskey D, Carson R. Variance reduction with synaptic density imaging in Parkinson’s disease using direct-4D PET image reconstruction. Physics In Medicine And Biology 2026, 71: 065007. PMID: 41825140, PMCID: PMC13014069, DOI: 10.1088/1361-6560/ae520a.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsNoninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models.
Hernández-Martín N, Balayeva T, Naganawa M, Asch R, Huang Y, Carson R, Gallezot J, Cai Z. Noninvasive Quantification of [18F]SynVesT-2 PET in Healthy Human Brains Using Simplified Reference Tissue Models. Journal Of Nuclear Medicine 2026, jnumed.125.271207. PMID: 41679926, DOI: 10.2967/jnumed.125.271207.Peer-Reviewed Original ResearchAltmetricConceptsTest-retest variabilityAbsolute test-retest variabilityDistribution volume ratioCerebral blood flowRelative cerebral blood flowDistribution volume ratio valuesBlood flowSV2A densityConclusion:Results:PET imagingNondisplaceable binding potentialClinical applicationMethods: DataReference tissue modelNeurological disordersSimplified reference tissue modelSynaptic vesicle glycoprotein 2ATime-activity curvesMinimum scan durationHealthy volunteersPET scansCentrum semiovaleClinical feasibilityScan timePatlak-Guided Self-Supervised Learning for Dynamic PET Denoising
Liu Q, Guo X, Tsai Y, Gallezot J, Chen M, Guo L, Xie H, Panin V, Carson R, Liu C. Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3656480.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioSelf-supervised deep learning frameworkSelf-supervised learningDeep learning frameworkCycleGAN-based modelDenoising NetworkConsistency lossLesion signal-to-noise ratioDynamic PET datasetsLearning frameworkSupervised methodsU-NetMulti-center datasetDenoisingCycleGANDatasetImage qualityPET datasetsDynamic framesFitting errorClinical deploymentImagesPhysiologically meaningful measuresDynamic PET dataFrame
2025
Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET
Zeng T, Najmaoui Y, Zhang J, Fontaine K, Hu Y, Chemli Y, Gallezot J, Sun C, Lu Y, Fakhri G, Carson R, Marin T. Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287015.Peer-Reviewed Original ResearchConceptsSpatially-varying point spread functionPoint spread functionAccurate point spread functionPSF modelConvergence behaviorImage qualityPoint spread function modelReconstruction toolboxPSF parametersHigh-activity regionsBrain-dedicated PET scannersDepth of interactionPoint-spread-function modelingField of viewSpatial resolutionHuman scansContrast recoverySpread functionPET systemPET scannerReal phantomBrain phantomMonte Carlo simulationsBrain positron emission tomographyCarlo simulationsImaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism
Naples A, Yang Y, Gravel P, Toyonaga T, Sadabad F, Koohsari S, Pittman B, Gallezot J, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Rodden I, Hillmer A, Esterlis I, Ropchan J, Nabulsi N, Huang Y, Wolf J, Carson R, McPartland J, Matuskey D. Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism. American Journal Of Psychiatry 2025, 183: 58-69. PMID: 41366835, DOI: 10.1176/appi.ajp.20241084.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMetabotropic glutamate receptor 5Glutamate receptor 5Positron emission tomographyAutistic groupGroup differencesPositron emission tomography outcomes measurementsExcitatory neurotransmissionNeurotypical control participantsAutism spectrum disorderReceptor 5Receptor availabilityAutism phenotypeAutistic adultsBrain areasBrain regionsExcitatory neural activitySpectrum disorderControl participantsSensory sensitivityMGlu5Neural activityVenous input functionsReceptor densityAutismEEG power spectraYRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER
Najmaoui Y, Fontaine K, Fontaine D, Zhang J, Zeng T, Volpi T, Chemli Y, Gallezot J, Tétrault M, Carson R, Fakhri G, Marin T. YRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER. 2025, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287275.Peer-Reviewed Original ResearchConceptsOpen-sourcePeak-to-valley ratioMini-Derenzo phantomReconstruction platformResolution PET scannerImage reconstruction toolsPacket decodingDetector geometryGPU accelerationMemory usagePET scannerPET systemAccurate system modelMotion correctionScatter estimationVendor softwareReconstruction timeImage reconstructionPluginImage qualitySoftwareHuman datasetsSystem modelManufacturing softwareNon-human primatesExceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT
Volpi T, Toyonaga T, Khattar N, Gallezot J, Naganawa M, Vanderlinden G, Honhar P, Zeng T, Fontaine K, Mulnix T, Hu L, Sun X, Henry S, Matuskey D, Radhakrishnan R, Guo L, Hu Y, Zhang J, Zheng X, Nabulsi N, Huang Y, Badawi R, Cherry S, Hillmer A, Jones T, Liu C, Morris E, Qi J, Li H, Carson R. Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 53: 2110-2121. PMID: 41177836, PMCID: PMC12860869, DOI: 10.1007/s00259-025-07605-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStandardized uptake valueTargeted radiopharmaceuticalsDopamine systemMultiple cortical areasSerotonin transporterRaphe nucleusMeasurement of tracer uptakeBrain regionsBrain structuresSubcortical nucleiPositron emission tomographyCortical areasSynaptic densityPET researchFocal uptakePaired scansUptake valueTracer uptakePET systemGray matterEarly imagesEmission tomographyHealthy individualsTracer deliveryNeuroExplorerYRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography
Najmaoui Y, Chemli Y, Toussaint M, Petibon Y, Marty B, Fontaine K, Gallezot J, Razdevsek G, Orehar M, Dhaynaut M, Guehl N, Dolenec R, Pestotnik R, Johnson K, Ouyang J, Normandin M, Tetrault M, Lecomte R, Fakhri G, Marin T. YRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. PMID: 41424471, PMCID: PMC12714321, DOI: 10.1109/trpms.2025.3619872.Peer-Reviewed Original ResearchConceptsOpen-sourceImage reconstructionPositron emission tomography image reconstructionReconstruction algorithmAdvanced image reconstruction algorithmsOpen-source toolkitDevelopment of advanced algorithmsTime-of-flightScanner geometryNovel reconstruction algorithmImage reconstruction algorithmMotion correctionReusable codeGPU accelerationTime-of-flight informationPython bindingsPlugin systemSoftware toolkitMeaningful imagesData formatsFast implementationRigid motion correctionAdvanced algorithmsPoint spread function modelProprietary softwareMeasuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study
Sadabad F, Volpi T, Honhar P, Tinaz S, Dias M, Toyonaga T, Naganawa M, Gallezot J, Yang Y, Ibrahim W, Pittman B, Cayir S, Radhakrishnan R, Angarita G, Holmes S, Comley R, Carson R, Finnema S, Matuskey D. Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study. Movement Disorders 2025, 40: 2678-2687. PMID: 41040062, DOI: 10.1002/mds.70041.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsC-UCB-JDopamine transporterHealthy controlsVentral striatumDisease stageSubstantia nigraSynaptic densityParkinson's diseaseDopamine transporter availabilityPositron emission tomography imaging studiesSynaptic vesicle glycoprotein 2AAssessment of synaptic densityDopaminergic denervationBetween-group differencesTransporter availabilityBinding potentialNigrostriatal regionDisease durationDual-tracerImaging studiesPatientsPET imagingPresynaptic degenerationPD patientsDopamineCarotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.
Volpi T, Gallezot J, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer A, Matuskey D, Carson R. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. Journal Of Nuclear Medicine 2025, 66: 1993-2001. PMID: 41043999, PMCID: PMC12676648, DOI: 10.2967/jnumed.125.270414.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsArea under the curveCommon carotidTime-activity curvesLate area under the curveMethods:Carotid arteryRegions-of-interestResults:Blood samplesPartial volume effectsImage-derived input functionArterial blood samplesArterial input functionAlternative to arterial blood samplingBlood time-activity curvesPET kinetic modelingGold standardInput functionBackground activityArterial samplesCarotidBrain-dedicated PET scannersBrain PET
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Radiology & Biomedical Imaging
PO Box 208042
New Haven, CT 06520-8042
United States